登録情報 | データベース: PDB / ID: 7av2 |
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タイトル | LTA4 hydrolase in complex with fragment1 |
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要素 | Leukotriene A-4 hydrolase |
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キーワード | HYDROLASE / Inhibitor / complex |
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機能・相同性 | 機能・相同性情報
leukotriene-A4 hydrolase / leukotriene-A4 hydrolase activity / tripeptide aminopeptidase activity / tripeptide aminopeptidase / Biosynthesis of protectins / Biosynthesis of aspirin-triggered D-series resolvins / Biosynthesis of E-series 18(R)-resolvins / Biosynthesis of D-series resolvins / Biosynthesis of E-series 18(S)-resolvins / protein metabolic process ...leukotriene-A4 hydrolase / leukotriene-A4 hydrolase activity / tripeptide aminopeptidase activity / tripeptide aminopeptidase / Biosynthesis of protectins / Biosynthesis of aspirin-triggered D-series resolvins / Biosynthesis of E-series 18(R)-resolvins / Biosynthesis of D-series resolvins / Biosynthesis of E-series 18(S)-resolvins / protein metabolic process / Synthesis of Leukotrienes (LT) and Eoxins (EX) / epoxide hydrolase activity / leukotriene biosynthetic process / type I pneumocyte differentiation / peptide catabolic process / response to zinc ion / metalloaminopeptidase activity / aminopeptidase activity / lipid metabolic process / response to peptide hormone / tertiary granule lumen / peptidase activity / ficolin-1-rich granule lumen / Neutrophil degranulation / proteolysis / RNA binding / extracellular exosome / zinc ion binding / extracellular region / nucleoplasm / nucleus / cytosol類似検索 - 分子機能 Leukotriene A4 hydrolase/leucine aminopeptidase / Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal / Aminopeptidase, leukotriene A4 hydrolase-like / Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily / : / Leukotriene A4 hydrolase, C-terminal / Leukotriene A4 hydrolase, C-terminal / Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase / Peptidase M1, membrane alanine aminopeptidase / Aminopeptidase N-like , N-terminal domain ...Leukotriene A4 hydrolase/leucine aminopeptidase / Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal / Aminopeptidase, leukotriene A4 hydrolase-like / Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily / : / Leukotriene A4 hydrolase, C-terminal / Leukotriene A4 hydrolase, C-terminal / Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase / Peptidase M1, membrane alanine aminopeptidase / Aminopeptidase N-like , N-terminal domain / Peptidase family M1 domain / Peptidase M1 N-terminal domain / Aminopeptidase N-like , N-terminal domain superfamliy / Peptidase M4/M1, CTD superfamily / Neutral zinc metallopeptidases, zinc-binding region signature. / Armadillo-type fold類似検索 - ドメイン・相同性 ACETATE ION / IMIDAZOLE / (4-phenoxyphenyl)methanol / YTTERBIUM (III) ION / Leukotriene A-4 hydrolase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.95 Å |
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データ登録者 | Srinivas, H. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2021 タイトル: Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. 著者: Markert, C. / Thoma, G. / Srinivas, H. / Bollbuck, B. / Luond, R.M. / Miltz, W. / Walchli, R. / Wolf, R. / Hinrichs, J. / Bergsdorf, C. / Azzaoui, K. / Penno, C.A. / Klein, K. / Wack, N. / ...著者: Markert, C. / Thoma, G. / Srinivas, H. / Bollbuck, B. / Luond, R.M. / Miltz, W. / Walchli, R. / Wolf, R. / Hinrichs, J. / Bergsdorf, C. / Azzaoui, K. / Penno, C.A. / Klein, K. / Wack, N. / Jager, P. / Hasler, F. / Beerli, C. / Loetscher, P. / Dawson, J. / Wieczorek, G. / Numao, S. / Littlewood-Evans, A. / Rohn, T.A. |
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履歴 | 登録 | 2020年11月3日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年2月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年2月24日 | Group: Database references / カテゴリ: citation_author / Item: _citation_author.name |
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改定 1.2 | 2021年3月3日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed ..._citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID |
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改定 1.3 | 2021年3月10日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.4 | 2024年1月31日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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