endothelial cell differentiation / positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis / negative regulation of endoplasmic reticulum unfolded protein response / oxidized pyrimidine DNA binding / response to TNF agonist / positive regulation of base-excision repair / protein tyrosine kinase inhibitor activity / positive regulation of respiratory burst involved in inflammatory response / regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage ...endothelial cell differentiation / positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis / negative regulation of endoplasmic reticulum unfolded protein response / oxidized pyrimidine DNA binding / response to TNF agonist / positive regulation of base-excision repair / protein tyrosine kinase inhibitor activity / positive regulation of respiratory burst involved in inflammatory response / regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage / positive regulation of gastrulation / nucleolus organization / IRE1-RACK1-PP2A complex / positive regulation of endodeoxyribonuclease activity / positive regulation of Golgi to plasma membrane protein transport / TNFR1-mediated ceramide production / negative regulation of DNA repair / negative regulation of RNA splicing / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / transcription regulator inhibitor activity / oxidized purine DNA binding / supercoiled DNA binding / neural crest cell differentiation / NF-kappaB complex / ubiquitin-like protein conjugating enzyme binding / regulation of establishment of cell polarity / negative regulation of phagocytosis / positive regulation of ubiquitin-protein transferase activity / rRNA modification in the nucleus and cytosol / Formation of the ternary complex, and subsequently, the 43S complex / erythrocyte homeostasis / cytoplasmic side of rough endoplasmic reticulum membrane / laminin receptor activity / protein kinase A binding / negative regulation of ubiquitin protein ligase activity / Ribosomal scanning and start codon recognition / ion channel inhibitor activity / Translation initiation complex formation / pigmentation / positive regulation of mitochondrial depolarization / mammalian oogenesis stage / positive regulation of DNA binding / activation-induced cell death of T cells / positive regulation of transcription by RNA polymerase I / negative regulation of Wnt signaling pathway / positive regulation of T cell receptor signaling pathway / fibroblast growth factor binding / positive regulation of activated T cell proliferation / iron-sulfur cluster binding / regulation of cell division / Protein hydroxylation / monocyte chemotaxis / negative regulation of peptidyl-serine phosphorylation / BH3 domain binding / mTORC1-mediated signalling / SARS-CoV-1 modulates host translation machinery / Peptide chain elongation / positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator / cysteine-type endopeptidase activator activity involved in apoptotic process / Selenocysteine synthesis / positive regulation of signal transduction by p53 class mediator / TFIID-class transcription factor complex binding / Formation of a pool of free 40S subunits / Eukaryotic Translation Termination / phagocytic cup / ubiquitin ligase inhibitor activity / Response of EIF2AK4 (GCN2) to amino acid deficiency / regulation of lipid metabolic process / SRP-dependent cotranslational protein targeting to membrane / negative regulation of respiratory burst involved in inflammatory response / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / Viral mRNA Translation / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / photoreceptor outer segment / GTP hydrolysis and joining of the 60S ribosomal subunit / TOR signaling / endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / L13a-mediated translational silencing of Ceruloplasmin expression / T cell proliferation involved in immune response / spindle assembly / Major pathway of rRNA processing in the nucleolus and cytosol / regulation of translational fidelity / erythrocyte development / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / negative regulation of ubiquitin-dependent protein catabolic process / Protein methylation / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / translation regulator activity / Nuclear events stimulated by ALK signaling in cancer / ribosomal small subunit export from nucleus / positive regulation of cell cycle / signaling adaptor activity / negative regulation of smoothened signaling pathway / positive regulation of intrinsic apoptotic signaling pathway / stress granule assembly / Mitotic Prometaphase / cytosolic ribosome / positive regulation of phagocytosis / laminin binding / EML4 and NUDC in mitotic spindle formation 類似検索 - 分子機能
Multiprotein bridging factor 1, N-terminal / Zinc finger, C2H2, LYAR-type / Cell growth-regulating nucleolar protein / Multiprotein bridging factor 1 / LYAR-type C2HC zinc finger / Zinc finger C2HC LYAR-type profile. / Acetyl-coA carboxylase zinc finger domain / Acetyl-CoA carboxylase zinc finger domain / Helix-turn-helix / Helix-turn-helix XRE-family like proteins ...Multiprotein bridging factor 1, N-terminal / Zinc finger, C2H2, LYAR-type / Cell growth-regulating nucleolar protein / Multiprotein bridging factor 1 / LYAR-type C2HC zinc finger / Zinc finger C2HC LYAR-type profile. / Acetyl-coA carboxylase zinc finger domain / Acetyl-CoA carboxylase zinc finger domain / Helix-turn-helix / Helix-turn-helix XRE-family like proteins / Cro/C1-type HTH domain profile. / Cro/C1-type helix-turn-helix domain / 40S ribosomal protein SA / 40S ribosomal protein SA, C-terminal domain / 40S ribosomal protein SA C-terminus / Ubiquitin-like protein FUBI / Lambda repressor-like, DNA-binding domain superfamily / : / Ribosomal protein S26e signature. / : / Ribosomal protein S26e / Ribosomal protein S26e superfamily / Ribosomal protein S26e / Ribosomal protein S21e, conserved site / Ribosomal protein S21e signature. / Ribosomal protein S12e signature. / Ribosomal protein S12e / Ribosomal protein S5, eukaryotic/archaeal / Ribosomal protein S19e, conserved site / Ribosomal protein S19e signature. / Small (40S) ribosomal subunit Asc1/RACK1 / Ribosomal protein S21e / Ribosomal protein S2, eukaryotic / Ribosomal protein S21e superfamily / Ribosomal protein S21e / S27a-like superfamily / 40S Ribosomal protein S10 / Ribosomal protein S10, eukaryotic/archaeal / Plectin/S10, N-terminal / Plectin/S10 domain / Ribosomal protein S25 / S25 ribosomal protein / Ribosomal protein S27a / Ribosomal protein S2, eukaryotic/archaeal / : / Ribosomal protein S27a / Ribosomal protein S27a / Ribosomal protein S17e, conserved site / Ribosomal protein S17e signature. / Ribosomal protein S8e subdomain, eukaryotes / Ribosomal protein S30 / Ribosomal protein S30 / 40S ribosomal protein S29/30S ribosomal protein S14 type Z / Ribosomal protein S7e signature. / Ribosomal protein S3, eukaryotic/archaeal / : / Ribosomal protein S19e / Ribosomal protein S3Ae, conserved site / Ribosomal protein S19e / Ribosomal protein S3Ae signature. / Ribosomal_S19e / Ribosomal protein S27e signature. / Ribosomal protein S4e, N-terminal, conserved site / Ribosomal protein S4e signature. / 40S ribosomal protein S4, C-terminal domain / 40S ribosomal protein S4 C-terminus / Ribosomal protein S19A/S15e / Ribosomal protein S8e, conserved site / Ribosomal protein S8e signature. / Ribosomal protein S17e / Ribosomal protein S17e-like superfamily / Ribosomal S17 / Ribosomal protein S6, eukaryotic / Ribosomal protein S4e, N-terminal / RS4NT (NUC023) domain / 40S ribosomal protein S1/3, eukaryotes / Ribosomal S24e conserved site / Ribosomal protein S24e signature. / 40S ribosomal protein S11, N-terminal / Ribosomal_S17 N-terminal / Ribosomal protein S7e / Ribosomal protein S7e / Ribosomal protein S4, KOW domain / Ribosomal protein S4e / Ribosomal protein S4e, central region / Ribosomal protein S4e, central domain superfamily / Ribosomal family S4e / Ribosomal protein S27, zinc-binding domain superfamily / Ribosomal protein S24e / Ribosomal protein S23, eukaryotic/archaeal / Ribosomal protein S24e / Ribosomal protein S6/S6e/A/B/2, conserved site / Ribosomal protein S6e signature. / Ribosomal protein S27 / Ribosomal protein S27 / Ribosomal protein S8e / Ribosomal protein S17, archaeal/eukaryotic / Ribosomal protein S28e conserved site / Ribosomal protein S28e signature. / Ribosomal protein S3Ae 類似検索 - ドメイン・相同性
RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / Endothelial differentiation-related factor 1 / Small ribosomal subunit protein eS17 / Small ribosomal subunit protein uS2 / Small ribosomal subunit protein uS5 / Small ribosomal subunit protein uS3 / Small ribosomal subunit protein eS12 ...RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / Endothelial differentiation-related factor 1 / Small ribosomal subunit protein eS17 / Small ribosomal subunit protein uS2 / Small ribosomal subunit protein uS5 / Small ribosomal subunit protein uS3 / Small ribosomal subunit protein eS12 / Small ribosomal subunit protein eS19 / Small ribosomal subunit protein eS27 / Small ribosomal subunit protein uS4 / Small ribosomal subunit protein uS7 / Small ribosomal subunit protein eS10 / Small ribosomal subunit protein uS10 / Small ribosomal subunit protein eS1 / Small ribosomal subunit protein eS7 / Small ribosomal subunit protein eS8 / Small ribosomal subunit protein uS8 / Small ribosomal subunit protein uS9 / Small ribosomal subunit protein uS11 / Small ribosomal subunit protein uS12 / Small ribosomal subunit protein uS13 / Small ribosomal subunit protein uS14 / Small ribosomal subunit protein uS15 / Small ribosomal subunit protein uS17 / Small ribosomal subunit protein eS4, X isoform / Small ribosomal subunit protein eS6 / Small ribosomal subunit protein uS19 / Small ribosomal subunit protein eS24 / Small ribosomal subunit protein eS25 / Small ribosomal subunit protein eS26 / Small ribosomal subunit protein eS28 / Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein / Ubiquitin-ribosomal protein eS31 fusion protein / Small ribosomal subunit protein eS21 / Small ribosomal subunit protein RACK1 / Cell growth-regulating nucleolar protein 類似検索 - 構成要素
National Institutes of Health/National Center for Research Resources (NIH/NCRR)
米国
引用
ジャーナル: Elife / 年: 2020 タイトル: EDF1 coordinates cellular responses to ribosome collisions. 著者: Niladri K Sinha / Alban Ordureau / Katharina Best / James A Saba / Boris Zinshteyn / Elayanambi Sundaramoorthy / Amit Fulzele / Danielle M Garshott / Timo Denk / Matthias Thoms / Joao A Paulo ...著者: Niladri K Sinha / Alban Ordureau / Katharina Best / James A Saba / Boris Zinshteyn / Elayanambi Sundaramoorthy / Amit Fulzele / Danielle M Garshott / Timo Denk / Matthias Thoms / Joao A Paulo / J Wade Harper / Eric J Bennett / Roland Beckmann / Rachel Green / 要旨: Translation of aberrant mRNAs induces ribosomal collisions, thereby triggering pathways for mRNA and nascent peptide degradation and ribosomal rescue. Here we use sucrose gradient fractionation ...Translation of aberrant mRNAs induces ribosomal collisions, thereby triggering pathways for mRNA and nascent peptide degradation and ribosomal rescue. Here we use sucrose gradient fractionation combined with quantitative proteomics to systematically identify proteins associated with collided ribosomes. This approach identified Endothelial differentiation-related factor 1 (EDF1) as a novel protein recruited to collided ribosomes during translational distress. Cryo-electron microscopic analyses of EDF1 and its yeast homolog Mbf1 revealed a conserved 40S ribosomal subunit binding site at the mRNA entry channel near the collision interface. EDF1 recruits the translational repressors GIGYF2 and EIF4E2 to collided ribosomes to initiate a negative-feedback loop that prevents new ribosomes from translating defective mRNAs. Further, EDF1 regulates an immediate-early transcriptional response to ribosomal collisions. Our results uncover mechanisms through which EDF1 coordinates multiple responses of the ribosome-mediated quality control pathway and provide novel insights into the intersection of ribosome-mediated quality control with global transcriptional regulation.
#195 - 2016年3月 RAFタンパク質キナーゼ (RAF Protein Kinases) 類似性 (1)
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集合体
登録構造単位
2: 18S rRNA A: 40S ribosomal protein SA B: 40S ribosomal protein S3a D: 40S ribosomal protein S3 E: 40S ribosomal protein S4, X isoform F: 40S ribosomal protein S5 H: 40S ribosomal protein S7 I: 40S ribosomal protein S8 K: 40S ribosomal protein S10 L: 40S ribosomal protein S11 P: 40S ribosomal protein S15 Q: 40S ribosomal protein S16 R: 40S ribosomal protein S17 S: 40S ribosomal protein S18 T: 40S ribosomal protein S19 U: 40S ribosomal protein S20 V: 40S ribosomal protein S21 X: 40S ribosomal protein S23 a: 40S ribosomal protein S26 c: 40S ribosomal protein S28 d: 40S ribosomal protein S29 g: Receptor of activated protein C kinase 1 C: 40S ribosomal protein S2 G: 40S ribosomal protein S6 J: 40S ribosomal protein S9 M: 40S ribosomal protein S12 N: 40S ribosomal protein S13 O: 40S ribosomal protein S14 W: 40S ribosomal protein S15a Y: 40S ribosomal protein S24 Z: 40S ribosomal protein S25 b: 40S ribosomal protein S27 e: 40S ribosomal protein S30 f: Ubiquitin-40S ribosomal protein S27a x: E-site tRNA y: Cell growth-regulating nucleolar protein i: Endothelial differentiation-related factor 1 ヘテロ分子
分子量: 24774.365 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P08865
#3: タンパク質
40SribosomalproteinS3a / Small ribosomal subunit protein eS1 / v-fos transformation effector protein / Fte-1
分子量: 30002.061 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P61247
#4: タンパク質
40SribosomalproteinS3 / Small ribosomal subunit protein uS3
分子量: 25172.561 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) 参照: UniProt: P23396, DNA-(apurinic or apyrimidinic site) lyase
#5: タンパク質
40SribosomalproteinS4, Xisoform / SCR10 / Single copy abundant mRNA protein / Small ribosomal subunit protein eS4
分子量: 29523.674 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62701
#6: タンパク質
40SribosomalproteinS5 / Small ribosomal subunit protein uS7
分子量: 21327.723 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P46782
#7: タンパク質
40SribosomalproteinS7 / Small ribosomal subunit protein eS7
分子量: 21603.229 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62081
#8: タンパク質
40SribosomalproteinS8 / Small ribosomal subunit protein eS8
分子量: 24003.012 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62241
#9: タンパク質
40SribosomalproteinS10 / Small ribosomal subunit protein eS10
分子量: 11773.953 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P46783
#10: タンパク質
40SribosomalproteinS11 / Small ribosomal subunit protein uS17
分子量: 17785.971 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62280
#11: タンパク質
40SribosomalproteinS15 / RIG protein / Small ribosomal subunit protein uS19
分子量: 15156.846 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62841
#12: タンパク質
40SribosomalproteinS16 / Small ribosomal subunit protein uS9
分子量: 16249.062 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62249
#13: タンパク質
40SribosomalproteinS17 / Small ribosomal subunit protein eS17
分子量: 15578.156 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P08708
#14: タンパク質
40SribosomalproteinS18 / Ke-3 / Ke3 / Small ribosomal subunit protein uS13
分子量: 17029.844 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62269
#15: タンパク質
40SribosomalproteinS19 / Small ribosomal subunit protein eS19
分子量: 15822.219 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P39019
#16: タンパク質
40SribosomalproteinS20 / Small ribosomal subunit protein uS10
分子量: 11765.890 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P60866
#17: タンパク質
40SribosomalproteinS21 / Small ribosomal subunit protein eS21
分子量: 9124.389 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P63220
#18: タンパク質
40SribosomalproteinS23 / Small ribosomal subunit protein uS12
分子量: 15626.392 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62266
#19: タンパク質
40SribosomalproteinS26 / Small ribosomal subunit protein eS26
分子量: 11742.908 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62854
#20: タンパク質
40SribosomalproteinS28 / Small ribosomal subunit protein eS28
分子量: 7263.394 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62857
#21: タンパク質
40SribosomalproteinS29 / Small ribosomal subunit protein uS14
分子量: 6559.625 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62273
#23: タンパク質
40SribosomalproteinS2 / 40S ribosomal protein S4 / Protein LLRep3 / Small ribosomal subunit protein uS5
分子量: 24587.029 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P15880
#24: タンパク質
40SribosomalproteinS6 / Phosphoprotein NP33 / Small ribosomal subunit protein eS6
分子量: 27471.535 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62753
#25: タンパク質
40SribosomalproteinS9 / Small ribosomal subunit protein uS4
分子量: 21649.633 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P46781
#26: タンパク質
40SribosomalproteinS12 / Small ribosomal subunit protein eS12
分子量: 13661.928 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P25398
#27: タンパク質
40SribosomalproteinS13 / Small ribosomal subunit protein uS15
分子量: 17128.191 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62277
#28: タンパク質
40SribosomalproteinS14 / Small ribosomal subunit protein uS11
分子量: 15014.187 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62263
#29: タンパク質
40SribosomalproteinS15a / Small ribosomal subunit protein uS8
分子量: 14734.357 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62244
#30: タンパク質
40SribosomalproteinS24 / Small ribosomal subunit protein eS24
分子量: 15203.022 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62847
#31: タンパク質
40SribosomalproteinS25 / Small ribosomal subunit protein eS25
分子量: 8526.119 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62851
#32: タンパク質
40SribosomalproteinS27 / Metallopan-stimulin 1 / MPS-1 / Small ribosomal subunit protein eS27
分子量: 9348.990 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P42677
#33: タンパク質・ペプチド
40SribosomalproteinS30 / Small ribosomal subunit protein eS30
分子量: 4896.883 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62861
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タンパク質 , 4種, 4分子 gfyi
#22: タンパク質
ReceptorofactivatedproteinCkinase1 / Cell proliferation-inducing gene 21 protein / Guanine nucleotide-binding protein subunit beta-2- ...Cell proliferation-inducing gene 21 protein / Guanine nucleotide-binding protein subunit beta-2-like 1 / Guanine nucleotide-binding protein subunit beta-like protein 12.3 / Human lung cancer oncogene 7 protein / HLC-7 / Receptor for activated C kinase / Small ribosomal subunit protein RACK1
分子量: 34669.113 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P63244
#34: タンパク質
Ubiquitin-40SribosomalproteinS27a / Ubiquitin carboxyl extension protein 80
分子量: 7884.286 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P62979
#36: タンパク質
Cellgrowth-regulatingnucleolarprotein
分子量: 8557.207 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: Q9NX58