登録情報 | データベース: PDB / ID: 6zfv |
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タイトル | Solution NMR structure of human GATA2 N-terminal zinc finger domain |
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要素 | Endothelial transcription factor GATA-2 |
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キーワード | TRANSCRIPTION / GATA / Transcription factor / Haematopoeisis |
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機能・相同性 | 機能・相同性情報
semicircular canal development / regulation of forebrain neuron differentiation / : / commitment of neuronal cell to specific neuron type in forebrain / ventral spinal cord interneuron differentiation / cell differentiation in hindbrain / regulation of primitive erythrocyte differentiation / eosinophil fate commitment / GABAergic neuron differentiation / negative regulation of fat cell proliferation ...semicircular canal development / regulation of forebrain neuron differentiation / : / commitment of neuronal cell to specific neuron type in forebrain / ventral spinal cord interneuron differentiation / cell differentiation in hindbrain / regulation of primitive erythrocyte differentiation / eosinophil fate commitment / GABAergic neuron differentiation / negative regulation of fat cell proliferation / negative regulation of macrophage differentiation / urogenital system development / glandular epithelial cell maturation / thyroid-stimulating hormone-secreting cell differentiation / negative regulation of brown fat cell differentiation / negative regulation of hematopoietic progenitor cell differentiation / negative regulation of neural precursor cell proliferation / hematopoietic stem cell homeostasis / positive regulation of megakaryocyte differentiation / vascular wound healing / positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of mast cell degranulation / positive regulation of phagocytosis, engulfment / cell fate determination / C2H2 zinc finger domain binding / definitive hemopoiesis / negative regulation of neuroblast proliferation / inner ear morphogenesis / positive regulation of cell migration involved in sprouting angiogenesis / response to lipid / cochlea development / negative regulation of fat cell differentiation / negative regulation of Notch signaling pathway / central nervous system neuron development / somatic stem cell population maintenance / neuroblast proliferation / embryonic placenta development / positive regulation of blood vessel endothelial cell migration / cell fate commitment / hematopoietic progenitor cell differentiation / negative regulation of endothelial cell apoptotic process / phagocytosis / brown fat cell differentiation / positive regulation of phagocytosis / homeostasis of number of cells within a tissue / positive regulation of neuron differentiation / positive regulation of erythrocyte differentiation / transcription coregulator binding / neuron migration / transcription coactivator binding / positive regulation of miRNA transcription / Transcriptional regulation of granulopoiesis / positive regulation of angiogenesis / sequence-specific double-stranded DNA binding / RUNX1 regulates transcription of genes involved in differentiation of HSCs / Factors involved in megakaryocyte development and platelet production / positive regulation of cytosolic calcium ion concentration / DNA-binding transcription activator activity, RNA polymerase II-specific / RNA polymerase II-specific DNA-binding transcription factor binding / transcription regulator complex / transcription by RNA polymerase II / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of gene expression / chromatin binding / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 Transcription factor, GATA-2/3 / Transcription factor GATA / GATA-type zinc finger domain. / GATA-type zinc finger domain profile. / zinc finger binding to DNA consensus sequence [AT]GATA[AG] / GATA zinc finger / Zinc finger, GATA-type / Zinc finger, NHR/GATA-type類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Nurmohamed, S.S. / Broadhurst, R.W. / May, G. / Enver, T. |
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資金援助 | 英国, 1件 組織 | 認可番号 | 国 |
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Kay Kendall Leukaemia Fund | | 英国 |
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引用 | ジャーナル: To Be Published タイトル: Solution NMR structure of human GATA2 C-terminal zinc finger domain 著者: Nurmohamed, S.S. / Broadhurst, R.W. / May, G. / Enver, T. |
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履歴 | 登録 | 2020年6月18日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年6月30日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年6月14日 | Group: Database references / Other / カテゴリ: database_2 / pdbx_database_status Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data |
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改定 1.2 | 2024年6月19日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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