登録情報 データベース : PDB / ID : 6zdr 構造の表示 ダウンロードとリンクタイトル Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with Chromone 4d 要素Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a 詳細 キーワード PROTEIN BINDING / G protein-coupled receptor / membrane protein / receptor機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of acetylcholine secretion, neurotransmission / positive regulation of circadian sleep/wake cycle, sleep / regulation of norepinephrine secretion / negative regulation of alpha-beta T cell activation / Adenosine P1 receptors / G protein-coupled adenosine receptor activity / G protein-coupled adenosine receptor signaling pathway / response to purine-containing compound / sensory perception / positive regulation of urine volume ... positive regulation of acetylcholine secretion, neurotransmission / positive regulation of circadian sleep/wake cycle, sleep / regulation of norepinephrine secretion / negative regulation of alpha-beta T cell activation / Adenosine P1 receptors / G protein-coupled adenosine receptor activity / G protein-coupled adenosine receptor signaling pathway / response to purine-containing compound / sensory perception / positive regulation of urine volume / NGF-independant TRKA activation / Surfactant metabolism / synaptic transmission, dopaminergic / : / inhibitory postsynaptic potential / negative regulation of vascular permeability / synaptic transmission, cholinergic / type 5 metabotropic glutamate receptor binding / positive regulation of glutamate secretion / blood circulation / response to caffeine / intermediate filament / eating behavior / presynaptic active zone / alpha-actinin binding / membrane depolarization / regulation of calcium ion transport / asymmetric synapse / axolemma / : / cellular defense response / prepulse inhibition / phagocytosis / response to amphetamine / presynaptic modulation of chemical synaptic transmission / excitatory postsynaptic potential / positive regulation of synaptic transmission, glutamatergic / neuron projection morphogenesis / regulation of mitochondrial membrane potential / synaptic transmission, glutamatergic / positive regulation of long-term synaptic potentiation / locomotory behavior / central nervous system development / astrocyte activation / positive regulation of synaptic transmission, GABAergic / positive regulation of protein secretion / apoptotic signaling pathway / electron transport chain / positive regulation of apoptotic signaling pathway / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / negative regulation of inflammatory response / vasodilation / blood coagulation / cell-cell signaling / presynaptic membrane / G alpha (s) signalling events / postsynaptic membrane / negative regulation of neuron apoptotic process / periplasmic space / electron transfer activity / calmodulin binding / response to xenobiotic stimulus / inflammatory response / iron ion binding / negative regulation of cell population proliferation / neuronal cell body / glutamatergic synapse / lipid binding / apoptotic process / dendrite / heme binding / protein-containing complex binding / regulation of DNA-templated transcription / enzyme binding / identical protein binding / membrane / plasma membrane 類似検索 - 分子機能 Adenosine A2A receptor / Adenosine receptor / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) 類似検索 - ドメイン・相同性 CHOLESTEROL / OLEIC ACID / (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate / Chem-QGE / Soluble cytochrome b562 / Adenosine receptor A2a 類似検索 - 構成要素生物種 Homo sapiens (ヒト)Escherichia coli (大腸菌)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.918 Å 詳細データ登録者 Verdon, G. / Jespers, W. / Azuaje, J. / Majellaro, M. / Keranen, H. / Garcia-mera, X. / Congreve, M. / Deflorian, F. / de Graaf, C. / Zhukov, A. ...Verdon, G. / Jespers, W. / Azuaje, J. / Majellaro, M. / Keranen, H. / Garcia-mera, X. / Congreve, M. / Deflorian, F. / de Graaf, C. / Zhukov, A. / Dore, A. / Mason, J. / Aqvist, J. / Cooke, R. / Sotelo, E. / Gutierrez-de-Teran, H. 引用ジャーナル : Angew.Chem.Int.Ed.Engl. / 年 : 2020タイトル : X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A 2A Adenosine Receptor Antagonists.著者: Jespers, W. / Verdon, G. / Azuaje, J. / Majellaro, M. / Keranen, H. / Garcia-Mera, X. / Congreve, M. / Deflorian, F. / de Graaf, C. / Zhukov, A. / Dore, A.S. / Mason, J.S. / Aqvist, J. / ... 著者 : Jespers, W. / Verdon, G. / Azuaje, J. / Majellaro, M. / Keranen, H. / Garcia-Mera, X. / Congreve, M. / Deflorian, F. / de Graaf, C. / Zhukov, A. / Dore, A.S. / Mason, J.S. / Aqvist, J. / Cooke, R.M. / Sotelo, E. / Gutierrez-de-Teran, H. 履歴 登録 2020年6月15日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2020年9月16日 Provider : repository / タイプ : Initial release改定 1.1 2020年12月16日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID 改定 1.2 2024年1月24日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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