登録情報 データベース : PDB / ID : 6zc8 構造の表示 ダウンロードとリンクタイトル Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling 要素Segment polarity protein dishevelled homolog DVL-3 詳細 キーワード PEPTIDE BINDING PROTEIN / PDZ / DVL / Inhibitors / Wnt / signalling機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Negative regulation of TCF-dependent signaling by DVL-interacting proteins / planar cell polarity pathway involved in neural tube closure / non-canonical Wnt signaling pathway / positive regulation of neuron projection arborization / WNT5:FZD7-mediated leishmania damping / frizzled binding / PCP/CE pathway / WNT mediated activation of DVL / Disassembly of the destruction complex and recruitment of AXIN to the membrane / Wnt signaling pathway, planar cell polarity pathway ... Negative regulation of TCF-dependent signaling by DVL-interacting proteins / planar cell polarity pathway involved in neural tube closure / non-canonical Wnt signaling pathway / positive regulation of neuron projection arborization / WNT5:FZD7-mediated leishmania damping / frizzled binding / PCP/CE pathway / WNT mediated activation of DVL / Disassembly of the destruction complex and recruitment of AXIN to the membrane / Wnt signaling pathway, planar cell polarity pathway / canonical Wnt signaling pathway / positive regulation of GTPase activity / TCF dependent signaling in response to WNT / Degradation of DVL / RHO GTPases Activate Formins / regulation of actin cytoskeleton organization / positive regulation of JNK cascade / beta-catenin binding / small GTPase binding / regulation of protein localization / protease binding / protein stabilization / intracellular signal transduction / response to xenobiotic stimulus / positive regulation of protein phosphorylation / signaling receptor binding / chromatin / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / cytosol 類似検索 - 分子機能 Dishevelled-3 / Dishevelled protein domain / Dishevelled family / Dishevelled C-terminal / Dishevelled specific domain / Segment polarity protein dishevelled (Dsh) C terminal / Dishevelled-related protein / DIX domain / DIX domain superfamily / DIX domain ... Dishevelled-3 / Dishevelled protein domain / Dishevelled family / Dishevelled C-terminal / Dishevelled specific domain / Segment polarity protein dishevelled (Dsh) C terminal / Dishevelled-related protein / DIX domain / DIX domain superfamily / DIX domain / DIX domain profile. / Domain present in Dishevelled and axin / Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) / DEP domain profile. / Domain found in Dishevelled, Egl-10, and Pleckstrin / DEP domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Ubiquitin-like domain superfamily / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily 類似検索 - ドメイン・相同性 Chem-QEK / Segment polarity protein dishevelled homolog DVL-3 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.76 Å 詳細データ登録者 Roske, Y. / Heinemann, U. / Oschkinat, H. 資金援助 ドイツ, 1件 詳細 詳細を隠す組織 認可番号 国 German Research Foundation (DFG) 806 ドイツ
引用ジャーナル : J.Magn.Reson. / 年 : 2021タイトル : Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling著者: Roske, Y. / Heinemann, U. / Oschkinat, H. / Kamdem, N. / Kovalskyy, D. / Platonov, M.O. / Balinskyi, O.M. / Kreuchwig, A. / Saupe, J. / Fang, L. / Diehl, A. / Schmieder, P. / Krause, G. / ... 著者 : Roske, Y. / Heinemann, U. / Oschkinat, H. / Kamdem, N. / Kovalskyy, D. / Platonov, M.O. / Balinskyi, O.M. / Kreuchwig, A. / Saupe, J. / Fang, L. / Diehl, A. / Schmieder, P. / Krause, G. / Rademann, J. / Birchmeier, W. 履歴 登録 2020年6月10日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2021年6月23日 Provider : repository / タイプ : Initial release改定 1.1 2022年7月20日 Group : Database references / カテゴリ : citation / database_2Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession 改定 1.2 2024年1月24日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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