- PDB-6z1q: MAP3K14 (NIK) in complex with DesF-3R/4076 -
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基本情報
登録情報
データベース: PDB / ID: 6z1q
タイトル
MAP3K14 (NIK) in complex with DesF-3R/4076
要素
Mitogen-activated protein kinase kinase kinase 14
キーワード
TRANSFERASE / Free energy perturbation / Lead Optimization / Multiple Myeloma / NIK / JNJ64290694
機能・相同性
機能・相同性情報
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / mitogen-activated protein kinase kinase kinase / MAP kinase kinase kinase activity / non-canonical NF-kappaB signal transduction / CD28 dependent PI3K/Akt signaling / canonical NF-kappaB signal transduction / NIK-->noncanonical NF-kB signaling / TNFR2 non-canonical NF-kB pathway / Dectin-1 mediated noncanonical NF-kB signaling / cellular response to mechanical stimulus ...TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / mitogen-activated protein kinase kinase kinase / MAP kinase kinase kinase activity / non-canonical NF-kappaB signal transduction / CD28 dependent PI3K/Akt signaling / canonical NF-kappaB signal transduction / NIK-->noncanonical NF-kB signaling / TNFR2 non-canonical NF-kB pathway / Dectin-1 mediated noncanonical NF-kB signaling / cellular response to mechanical stimulus / fibrillar center / defense response to virus / protein kinase activity / immune response / intracellular membrane-bounded organelle / protein serine kinase activity / protein serine/threonine kinase activity / nucleoplasm / ATP binding / cytosol 類似検索 - 分子機能
Mitogen-activated protein (MAP) kinase kinase kinase 14 / M3K14, catalytic domain / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. ...Mitogen-activated protein (MAP) kinase kinase kinase 14 / M3K14, catalytic domain / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性