Entry | Database: PDB / ID: 6yvh |
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Title | CWC22-CWC27-EIF4A3 Complex |
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Components | - Eukaryotic initiation factor 4A-III
- Pre-mRNA-splicing factor CWC22 homolog
- Spliceosome-associated protein CWC27 homolog
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Keywords | RNA BINDING PROTEIN / EJC Helicase |
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Function / homology | Function and homology information
negative regulation of selenocysteine incorporation / regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / cellular response to selenite ion / exon-exon junction complex / regulation of translation at postsynapse, modulating synaptic transmission / negative regulation of excitatory postsynaptic potential / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / selenocysteine insertion sequence binding / Deadenylation of mRNA / poly(A) binding ...negative regulation of selenocysteine incorporation / regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / cellular response to selenite ion / exon-exon junction complex / regulation of translation at postsynapse, modulating synaptic transmission / negative regulation of excitatory postsynaptic potential / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / selenocysteine insertion sequence binding / Deadenylation of mRNA / poly(A) binding / M-decay: degradation of maternal mRNAs by maternally stored factors / mRNA 3'-end processing / U2-type catalytic step 1 spliceosome / embryonic cranial skeleton morphogenesis / regulation of mRNA splicing, via spliceosome / U2-type precatalytic spliceosome / Transport of Mature mRNA derived from an Intron-Containing Transcript / U2-type catalytic step 2 spliceosome / RNA Polymerase II Transcription Termination / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / exploration behavior / associative learning / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / mRNA export from nucleus / ribonucleoprotein complex binding / cellular response to brain-derived neurotrophic factor stimulus / catalytic step 2 spliceosome / mRNA Splicing - Major Pathway / positive regulation of translation / spliceosomal complex / response to organic cyclic compound / ISG15 antiviral mechanism / Regulation of expression of SLITs and ROBOs / mRNA splicing, via spliceosome / RNA stem-loop binding / rRNA processing / protein folding / postsynapse / RNA helicase activity / negative regulation of translation / RNA helicase / nuclear speck / mRNA binding / neuronal cell body / glutamatergic synapse / dendrite / nucleolus / ATP hydrolysis activity / RNA binding / nucleoplasm / ATP binding / membrane / nucleus / cytoplasm / cytosolSimilarity search - Function Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat - #180 / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like / Initiation factor eIF-4 gamma, MA3 / MA3 domain / MI domain profile. / Domain in DAP-5, eIF4G, MA-3 and other proteins. / MIF4G domain / Middle domain of eukaryotic initiation factor 4G (eIF4G) / MIF4G-like, type 3 / DEAD-box subfamily ATP-dependent helicases signature. ...Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat - #180 / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like / Initiation factor eIF-4 gamma, MA3 / MA3 domain / MI domain profile. / Domain in DAP-5, eIF4G, MA-3 and other proteins. / MIF4G domain / Middle domain of eukaryotic initiation factor 4G (eIF4G) / MIF4G-like, type 3 / DEAD-box subfamily ATP-dependent helicases signature. / ATP-dependent RNA helicase DEAD-box, conserved site / RNA helicase, DEAD-box type, Q motif / DEAD-box RNA helicase Q motif profile. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site / Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain profile. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain / Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD / Cyclophilin-like domain superfamily / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / Helicase conserved C-terminal domain / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / Armadillo-type fold / P-loop containing nucleotide triphosphate hydrolases / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology Eukaryotic initiation factor 4A-III / Spliceosome-associated protein CWC27 homolog / Pre-mRNA-splicing factor CWC22 homologSimilarity search - Component |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.19 Å |
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Authors | Basquin, J. / Busetto, V. / LeHir, H. / Conti, E. |
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Funding support | France, 1items Organization | Grant number | Country |
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French National Research Agency | ANR-13-BSV8-0023 | France |
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Citation | Journal: Nucleic Acids Res. / Year: 2020 Title: Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes. Authors: Busetto, V. / Barbosa, I. / Basquin, J. / Marquenet, E. / Hocq, R. / Hennion, M. / Paternina, J.A. / Namane, A. / Conti, E. / Bensaude, O. / Le Hir, H. |
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History | Deposition | Apr 28, 2020 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | May 13, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jun 10, 2020 | Group: Database references / Category: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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Revision 1.2 | Jan 24, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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