登録情報 データベース : PDB / ID : 6xxf 構造の表示 ダウンロードとリンクタイトル 1.7 Angstrom crystal structure of Ca/CaM:RyR2 peptide complex 要素 詳細 キーワード METAL BINDING PROTEIN / calcium-binding protein / cardiac muscle contraction / RyR2機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of calcium ion transmembrane transporter activity / positive regulation of cyclic-nucleotide phosphodiesterase activity / negative regulation of calcium ion export across plasma membrane / positive regulation of ryanodine-sensitive calcium-release channel activity / regulation of cell communication by electrical coupling involved in cardiac conduction / negative regulation of peptidyl-threonine phosphorylation / protein phosphatase activator activity / positive regulation of phosphoprotein phosphatase activity / adenylate cyclase binding / catalytic complex ... negative regulation of calcium ion transmembrane transporter activity / positive regulation of cyclic-nucleotide phosphodiesterase activity / negative regulation of calcium ion export across plasma membrane / positive regulation of ryanodine-sensitive calcium-release channel activity / regulation of cell communication by electrical coupling involved in cardiac conduction / negative regulation of peptidyl-threonine phosphorylation / protein phosphatase activator activity / positive regulation of phosphoprotein phosphatase activity / adenylate cyclase binding / catalytic complex / detection of calcium ion / regulation of cardiac muscle contraction / negative regulation of ryanodine-sensitive calcium-release channel activity / calcium channel inhibitor activity / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / positive regulation of protein dephosphorylation / regulation of calcium-mediated signaling / titin binding / positive regulation of protein autophosphorylation / voltage-gated potassium channel complex / sperm midpiece / calcium channel complex / substantia nigra development / adenylate cyclase activator activity / regulation of heart rate / sarcomere / protein serine/threonine kinase activator activity / regulation of cytokinesis / positive regulation of peptidyl-threonine phosphorylation / positive regulation of protein serine/threonine kinase activity / spindle microtubule / spindle pole / response to calcium ion / G2/M transition of mitotic cell cycle / calcium-dependent protein binding / myelin sheath / vesicle / transmembrane transporter binding / G protein-coupled receptor signaling pathway / centrosome / calcium ion binding / protein kinase binding / protein-containing complex / membrane / nucleus / plasma membrane / cytoplasm 類似検索 - 分子機能 EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.7 Å 詳細データ登録者 Antonyuk, S. / Helassa, N. 資金援助 英国, 1件 詳細 詳細を隠す組織 認可番号 国 British Heart Foundation FS/17/56/32925 英国
引用ジャーナル : J.Cell.Sci. / 年 : 2022タイトル : CPVT-associated calmodulin variants N53I and A102V dysregulate Ca2+ signalling via different mechanisms.著者 : Prakash, O. / Held, M. / McCormick, L.F. / Gupta, N. / Lian, L.Y. / Antonyuk, S. / Haynes, L.P. / Thomas, N.L. / Helassa, N. 履歴 登録 2020年1月27日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2021年2月10日 Provider : repository / タイプ : Initial release改定 1.1 2021年12月22日 Group : Advisory / Database referencesカテゴリ : citation / citation_author ... citation / citation_author / database_2 / pdbx_unobs_or_zero_occ_atoms Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession 改定 1.2 2022年1月26日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.title ... _citation.journal_volume / _citation.title / _citation.year / _citation_author.identifier_ORCID 改定 1.3 2024年1月24日 Group : Data collection / Derived calculations / Refinement descriptionカテゴリ : atom_type / chem_comp_atom ... atom_type / chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model Item : _atom_type.pdbx_N_electrons / _atom_type.pdbx_scat_Z
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