Entry | Database: PDB / ID: 6w9t |
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Title | Crystal structure of Neisseria meningitidis ClpP protease complex with small molecule activator ACP1-06 |
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Components | ATP-dependent Clp protease proteolytic subunit |
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Keywords | HYDROLASE / Serine protease / proteostasis / activator / complex / antibacterial drugs |
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Function / homology | Function and homology information
endopeptidase Clp / endopeptidase Clp complex / ATP-dependent peptidase activity / protein quality control for misfolded or incompletely synthesized proteins / ATPase binding / serine-type endopeptidase activity / cytoplasmSimilarity search - Function ClpP, Ser active site / Endopeptidase Clp serine active site. / ClpP, histidine active site / Endopeptidase Clp histidine active site. / ATP-dependent Clp protease proteolytic subunit / Clp protease proteolytic subunit /Translocation-enhancing protein TepA / Clp protease / ClpP/crotonase-like domain superfamilySimilarity search - Domain/homology |
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Biological species | Neisseria meningitidis (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.64 Å |
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Authors | Mabanglo, M.F. / Houry, W.A. |
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Funding support | Canada, 1items Organization | Grant number | Country |
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Canadian Institutes of Health Research (CIHR) | PJT-148564 | Canada |
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Citation | Journal: Acs Infect Dis. / Year: 2020 Title: Development of Antibiotics That Dysregulate the Neisserial ClpP Protease. Authors: Binepal, G. / Mabanglo, M.F. / Goodreid, J.D. / Leung, E. / Barghash, M.M. / Wong, K.S. / Lin, F. / Cossette, M. / Bansagi, J. / Song, B. / Balasco Serrao, V.H. / Pai, E.F. / Batey, R.A. / ...Authors: Binepal, G. / Mabanglo, M.F. / Goodreid, J.D. / Leung, E. / Barghash, M.M. / Wong, K.S. / Lin, F. / Cossette, M. / Bansagi, J. / Song, B. / Balasco Serrao, V.H. / Pai, E.F. / Batey, R.A. / Gray-Owen, S.D. / Houry, W.A. |
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History | Deposition | Mar 23, 2020 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Dec 9, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 23, 2020 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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Revision 1.2 | Oct 18, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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