登録情報 | データベース: PDB / ID: 6vkj |
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タイトル | Crystal structure of the G domain of human guanylate-binding protein 2 (hGBP2) in complex with GDP |
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要素 | Guanylate-binding protein 2 |
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キーワード | HYDROLASE / large GTPase / immune signaling / NTPase / guanylate binding |
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機能・相同性 | 機能・相同性情報
positive regulation of AIM2 inflammasome complex assembly / cytolysis in another organism / positive regulation of pyroptotic inflammatory response / endopeptidase inhibitor activity / molecular function inhibitor activity / defense response to protozoan / protein localization to nucleus / cellular response to interleukin-1 / activation of innate immune response / 加水分解酵素; 酸無水物に作用; GTPに作用・細胞または細胞小器官の運動に関与 ...positive regulation of AIM2 inflammasome complex assembly / cytolysis in another organism / positive regulation of pyroptotic inflammatory response / endopeptidase inhibitor activity / molecular function inhibitor activity / defense response to protozoan / protein localization to nucleus / cellular response to interleukin-1 / activation of innate immune response / 加水分解酵素; 酸無水物に作用; GTPに作用・細胞または細胞小器官の運動に関与 / cytoplasmic vesicle membrane / cellular response to type II interferon / Interferon gamma signaling / Interferon alpha/beta signaling / cellular response to tumor necrosis factor / cytoplasmic vesicle / cellular response to lipopolysaccharide / defense response to virus / defense response to Gram-positive bacterium / defense response to bacterium / immune response / Golgi membrane / GTPase activity / GTP binding / perinuclear region of cytoplasm / Golgi apparatus / protein homodimerization activity / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Guanylate-binding protein, C-terminal / Guanylate-binding protein/Atlastin, C-terminal / Guanylate-binding protein, C-terminal domain / Guanylate-binding protein, N-terminal / Guanylate-binding protein, C-terminal domain superfamily / Guanylate-binding protein, N-terminal domain / GB1/RHD3-type guanine nucleotide-binding (G) domain / GB1/RHD3-type guanine nucleotide-binding (G) domain profile. / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 GUANOSINE-5'-DIPHOSPHATE / Guanylate-binding protein 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.105 Å |
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データ登録者 | Roy, S. / Wang, B. / Tian, Y. / Yin, Q. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R00AI108793 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Crystal structure of the G domain of human guanylate-binding protein 2 (hGBP2) in complex with GDP 著者: Roy, S. / Wang, B. / Tian, Y. / Yin, Q. |
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履歴 | 登録 | 2020年1月21日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2021年1月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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