Entry | Database: PDB / ID: 6vj9 |
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Title | Crystal structure of GlpG in complex with peptide boronate inhibitor |
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Components | - ACE-VAL-ARG-MET-B2A
- Rhomboid family intramembrane serine protease GlpG
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / inhibitor / complex / GlpG / rhomboid protease / HYDROLASE-HYDROLASE INHIBITOR complex |
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Function / homology | Function and homology information
rhomboid protease / endopeptidase activity / membrane => GO:0016020 / serine-type endopeptidase activity / proteolysis / identical protein binding / plasma membraneSimilarity search - Function Peptidase S54, GlpG peptidase, N-terminal / Rhomboid protease GlpG / GlpG peptidase, N-terminal domain superfamily / Cytoplasmic N-terminal domain of rhomboid serine protease / Peptidase S54, rhomboid domain / Rhomboid family / Rhomboid-like superfamilySimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Escherichia coli (E. coli)
![](img/tx_arthropod.gif) Drosophila melanogaster (fruit fly) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.3 Å |
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Authors | Urban, S. / Cho, S. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) | R01AI066025 | United States |
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Citation | Journal: Cell Chem Biol / Year: 2020 Title: Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Authors: Gandhi, S. / Baker, R.P. / Cho, S. / Stanchev, S. / Strisovsky, K. / Urban, S. |
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History | Deposition | Jan 15, 2020 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Sep 16, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 2, 2020 | Group: Database references / Category: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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Revision 1.2 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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Revision 1.3 | Nov 15, 2023 | Group: Data collection / Category: chem_comp_atom / chem_comp_bond / Item: _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 |
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