登録情報 | データベース: PDB / ID: 6vfo |
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タイトル | Solution structure of the PHD of mouse UHRF1 (NP95) |
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要素 | E3 ubiquitin-protein ligase UHRF1 |
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キーワード | PEPTIDE BINDING PROTEIN / Histone / Plant Homeodomain / NP95 / H3K9me3 |
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機能・相同性 | 機能・相同性情報
histone H3 ubiquitin ligase activity / hemi-methylated DNA-binding / regulation of epithelial cell proliferation / methyl-CpG binding / negative regulation of gene expression via chromosomal CpG island methylation / mitotic spindle assembly / cis-regulatory region sequence-specific DNA binding / protein autoubiquitination / heterochromatin / methylated histone binding ...histone H3 ubiquitin ligase activity / hemi-methylated DNA-binding / regulation of epithelial cell proliferation / methyl-CpG binding / negative regulation of gene expression via chromosomal CpG island methylation / mitotic spindle assembly / cis-regulatory region sequence-specific DNA binding / protein autoubiquitination / heterochromatin / methylated histone binding / positive regulation of protein metabolic process / replication fork / RING-type E3 ubiquitin transferase / heterochromatin formation / euchromatin / nuclear matrix / ubiquitin protein ligase activity / histone binding / ubiquitin-dependent protein catabolic process / protein ubiquitination / DNA repair / chromatin / negative regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / identical protein binding / nucleus / cytosol類似検索 - 分子機能 : / UHRF1, tandem tudor domain / UHRF1/2-like / Tandem tudor domain within UHRF1 / SRA-YDG / SRA-YDG superfamily / SAD/SRA domain / YDG domain profile. / SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. / PUA-like superfamily ...: / UHRF1, tandem tudor domain / UHRF1/2-like / Tandem tudor domain within UHRF1 / SRA-YDG / SRA-YDG superfamily / SAD/SRA domain / YDG domain profile. / SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. / PUA-like superfamily / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / PHD-finger / Ring finger / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, FYVE/PHD-type / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Zinc finger, RING/FYVE/PHD-type / Ubiquitin-like domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | 溶液NMR / molecular dynamics |
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データ登録者 | Lemak, A. / Houliston, S. / Duan, S. / Arrowsmith, C.H. |
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資金援助 | カナダ, 1件 組織 | 認可番号 | 国 |
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Natural Sciences and Engineering Research Council (NSERC, Canada) | RGPIN-2015-05939 | カナダ |
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引用 | ジャーナル: Nucleic Acids Res. / 年: 2020 タイトル: Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1. 著者: Tauber, M. / Kreuz, S. / Lemak, A. / Mandal, P. / Yerkesh, Z. / Veluchamy, A. / Al-Gashgari, B. / Aljahani, A. / Cortes-Medina, L.V. / Azhibek, D. / Fan, L. / Ong, M.S. / Duan, S. / ...著者: Tauber, M. / Kreuz, S. / Lemak, A. / Mandal, P. / Yerkesh, Z. / Veluchamy, A. / Al-Gashgari, B. / Aljahani, A. / Cortes-Medina, L.V. / Azhibek, D. / Fan, L. / Ong, M.S. / Duan, S. / Houliston, S. / Arrowsmith, C.H. / Fischle, W. |
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履歴 | 登録 | 2020年1月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年6月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年7月15日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2020年9月2日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2023年6月14日 | Group: Database references / Other / カテゴリ: database_2 / pdbx_database_status Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data |
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改定 1.4 | 2024年5月15日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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