登録情報 | データベース: PDB / ID: 6v9u |
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タイトル | Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 14c |
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要素 | Toll-like receptor 8 |
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キーワード | RNA BINDING PROTEIN / Toll-like receptor / pattern recognition receptor / pathogen-associated molecular patterns / innate immunity / endosomal receptor |
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機能・相同性 | 機能・相同性情報
Toll Like Receptor 7/8 (TLR7/8) Cascade / toll-like receptor 8 signaling pathway / negative regulation of interleukin-12 production / endolysosome membrane / positive regulation of innate immune response / Trafficking and processing of endosomal TLR / pattern recognition receptor activity / toll-like receptor signaling pathway / immunoglobulin mediated immune response / canonical NF-kappaB signal transduction ...Toll Like Receptor 7/8 (TLR7/8) Cascade / toll-like receptor 8 signaling pathway / negative regulation of interleukin-12 production / endolysosome membrane / positive regulation of innate immune response / Trafficking and processing of endosomal TLR / pattern recognition receptor activity / toll-like receptor signaling pathway / immunoglobulin mediated immune response / canonical NF-kappaB signal transduction / positive regulation of interferon-alpha production / positive regulation of interferon-beta production / positive regulation of interleukin-1 beta production / positive regulation of interleukin-8 production / regulation of protein phosphorylation / response to virus / cellular response to mechanical stimulus / positive regulation of interleukin-6 production / positive regulation of type II interferon production / double-stranded RNA binding / signaling receptor activity / defense response to virus / single-stranded RNA binding / endosome membrane / inflammatory response / external side of plasma membrane / Golgi membrane / innate immune response / endoplasmic reticulum membrane / SARS-CoV-2 activates/modulates innate and adaptive immune responses / DNA binding / RNA binding / identical protein binding / plasma membrane類似検索 - 分子機能 TIR domain / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Toll - interleukin 1 - resistance / Leucine-rich repeat, SDS22-like subfamily / TIR domain profile. / Toll/interleukin-1 receptor homology (TIR) domain / Toll/interleukin-1 receptor homology (TIR) domain superfamily / Leucine rich repeat / Leucine-rich repeat, typical subtype ...TIR domain / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Toll - interleukin 1 - resistance / Leucine-rich repeat, SDS22-like subfamily / TIR domain profile. / Toll/interleukin-1 receptor homology (TIR) domain / Toll/interleukin-1 receptor homology (TIR) domain superfamily / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.65 Å |
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データ登録者 | Critton, D.A. |
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引用 | ジャーナル: Acs Med.Chem.Lett. / 年: 2020 タイトル: Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9). 著者: Mussari, C.P. / Dodd, D.S. / Sreekantha, R.K. / Pasunoori, L. / Wan, H. / Posy, S.L. / Critton, D. / Ruepp, S. / Subramanian, M. / Watson, A. / Davies, P. / Schieven, G.L. / Salter-Cid, L.M. ...著者: Mussari, C.P. / Dodd, D.S. / Sreekantha, R.K. / Pasunoori, L. / Wan, H. / Posy, S.L. / Critton, D. / Ruepp, S. / Subramanian, M. / Watson, A. / Davies, P. / Schieven, G.L. / Salter-Cid, L.M. / Srivastava, R. / Tagore, D.M. / Dudhgaonkar, S. / Poss, M.A. / Carter, P.H. / Dyckman, A.J. |
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履歴 | 登録 | 2019年12月16日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年8月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年10月7日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name |
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改定 1.2 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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