Entry | Database: PDB / ID: 6tzt |
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Title | Crystal structure of human alpha/epsilon-COP of the COPI vesicular coat bound to alpha-COP STM2 |
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Components | - Coatomer subunit alpha
- Coatomer subunit epsilon
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Keywords | TRANSPORT PROTEIN |
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Function / homology | Function and homology information
protein localization to axon / pancreatic juice secretion / COPI vesicle coat / intra-Golgi vesicle-mediated transport / retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum / COPI-dependent Golgi-to-ER retrograde traffic / endoplasmic reticulum to Golgi vesicle-mediated transport / COPI-mediated anterograde transport / transport vesicle / intracellular protein transport ...protein localization to axon / pancreatic juice secretion / COPI vesicle coat / intra-Golgi vesicle-mediated transport / retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum / COPI-dependent Golgi-to-ER retrograde traffic / endoplasmic reticulum to Golgi vesicle-mediated transport / COPI-mediated anterograde transport / transport vesicle / intracellular protein transport / hormone activity / protein transport / growth cone / Golgi membrane / endoplasmic reticulum membrane / structural molecule activity / Golgi apparatus / extracellular space / extracellular exosome / nucleoplasm / membrane / cytosol / cytoplasmSimilarity search - Function Coatomer epsilon subunit / Coatomer, epsilon subunit / : / Coatomer, alpha subunit, C-terminal / Coatomer subunit alpha / Coatomer (COPI) alpha subunit C-terminus / : / Coatomer, WD associated region / Coatomer WD associated region / Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily ...Coatomer epsilon subunit / Coatomer, epsilon subunit / : / Coatomer, alpha subunit, C-terminal / Coatomer subunit alpha / Coatomer (COPI) alpha subunit C-terminus / : / Coatomer, WD associated region / Coatomer WD associated region / Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily / Tetratricopeptide repeat domain / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Tetratricopeptide-like helical domain superfamily / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.065 Å |
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Authors | Travis, S.M. / Hughson, F.M. |
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Funding support | United States, 3items Organization | Grant number | Country |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM071574 | United States | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | F31GM12676 | United States | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | T32GM007388 | United States |
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Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2019 Title: Roles of singleton tryptophan motifs in COPI coat stability and vesicle tethering. Authors: Travis, S.M. / Kokona, B. / Fairman, R. / Hughson, F.M. |
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History | Deposition | Aug 13, 2019 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Nov 13, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 27, 2019 | Group: Database references / Category: citation / citation_author Item: _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID |
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Revision 1.2 | Dec 11, 2019 | Group: Database references / Category: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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Revision 1.3 | Jan 1, 2020 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.4 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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