A: Amyloid-beta precursor protein B: Amyloid-beta precursor protein C: Amyloid-beta precursor protein D: Amyloid-beta precursor protein E: Amyloid-beta precursor protein F: Amyloid-beta precursor protein G: Amyloid-beta precursor protein H: Amyloid-beta precursor protein I: Amyloid-beta precursor protein J: Amyloid-beta precursor protein K: Amyloid-beta precursor protein L: Amyloid-beta precursor protein M: Amyloid-beta precursor protein N: Amyloid-beta precursor protein O: Amyloid-beta precursor protein P: Amyloid-beta precursor protein
Evidence: scanning transmission electron microscopy, The resulting fibrils appear short and highly associated in flat bundles, which do not disassemble to isolated fibrils upon sonication.
Type
Name
Symmetry operation
Number
identity operation
1_555
1
Buried area
41840 Å2
ΔGint
-252 kcal/mol
Surface area
19260 Å2
Method
PISA
NMR ensembles
Data
Criteria
Number of conformers (submitted / calculated)
4 / 200
Top 4 Structures From Haddock
Representative
Model #1
lowest energy
-
Components
#1: Protein/peptide
Amyloid-betaprecursorprotein / APP / ABPP / APPI / Alzheimer disease amyloid protein / Amyloid precursor protein / Amyloid-beta A4 ...APP / ABPP / APPI / Alzheimer disease amyloid protein / Amyloid precursor protein / Amyloid-beta A4 protein / Cerebral vascular amyloid peptide / CVAP / PreA4 / Protease nexin-II / PN-II
Mass: 4335.852 Da / Num. of mol.: 8 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: APP, A4, AD1 / Production host: Escherichia coli (E. coli) / References: UniProt: P05067
#2: Protein/peptide
Amyloid-betaprecursorprotein / APP / ABPP / APPI / Alzheimer disease amyloid protein / Amyloid precursor protein / Amyloid-beta A4 ...APP / ABPP / APPI / Alzheimer disease amyloid protein / Amyloid precursor protein / Amyloid-beta A4 protein / Cerebral vascular amyloid peptide / CVAP / PreA4 / Protease nexin-II / PN-II
Mass: 4520.087 Da / Num. of mol.: 8 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: APP, A4, AD1 / Production host: Escherichia coli (E. coli) / References: UniProt: P05067
-
Experimental details
-
Experiment
Experiment
Method: SOLID-STATE NMR
NMR experiment
Conditions-ID
Experiment-ID
Solution-ID
Sample state
Spectrometer-ID
Type
1
1
1
anisotropic
2
2D 15N-13C NCA
1
2
1
anisotropic
2
2D 15N-13C NCO
1
3
1
anisotropic
2
3DNCACX
1
4
1
anisotropic
2
3D NCOCX
1
5
1
anisotropic
2
3DNCACB
1
6
1
anisotropic
2
3DN(CO)CACB
1
7
1
anisotropic
2
3DCANCO
1
8
1
anisotropic
1
2D 13C 13C SHANGHAI (15-300 ms)
1
9
1
anisotropic
1
2D 13C-13C PDSD (400, 800 ms)
1
10
1
anisotropic
1
2D 13C-15N PAIN (10 ms)
1
11
2
anisotropic
2
2D 15N-13C NCA
1
12
2
anisotropic
1
2D 13C-13C DARR (100 ms)
1
13
3
anisotropic
2
2D 15N-13C NCA
1
14
3
anisotropic
2
2D 15N-13C NCO
1
15
3
anisotropic
1
2D 13C-13C SHANGHAI (15-300 ms)
1
16
4
anisotropic
3
2D 15N-13C hNhhC
-
Sample preparation
Details
Type
Solution-ID
Contents
Details
Label
Solvent system
fiber
1
50 uM [U-100% 13C; U-100% 15N] Amyloid-beta peptide 1-40, 50 uM Amyloid-beta peptide 1-42, 50 mM ammonium acetate, H2O
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