登録情報 | データベース: PDB / ID: 6ssq |
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タイトル | Crystal structure of RARbeta LBD in complex with LG 100754 |
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要素 | - Nuclear receptor coactivator 1核内受容体コアクチベーター1
- Retinoic acid receptor beta
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キーワード | TRANSCRIPTION (転写 (生物学)) / Nuclear receptor (核内受容体) / Ligand binding (リガンド) |
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機能・相同性 | 機能・相同性情報
ventricular cardiac muscle cell differentiation / embryonic eye morphogenesis / glandular epithelial cell development / cellular response to corticotropin-releasing hormone stimulus / growth plate cartilage development / embryonic digestive tract development / nuclear glucocorticoid receptor binding / striatum development / neural precursor cell proliferation / labyrinthine layer morphogenesis ...ventricular cardiac muscle cell differentiation / embryonic eye morphogenesis / glandular epithelial cell development / cellular response to corticotropin-releasing hormone stimulus / growth plate cartilage development / embryonic digestive tract development / nuclear glucocorticoid receptor binding / striatum development / neural precursor cell proliferation / labyrinthine layer morphogenesis / negative regulation of chondrocyte differentiation / regulation of thyroid hormone mediated signaling pathway / embryonic hindlimb morphogenesis / positive regulation of transcription from RNA polymerase II promoter by galactose / positive regulation of female receptivity / ureteric bud development / regulation of myelination / Signaling by Retinoic Acid / hypothalamus development / male mating behavior / heterocyclic compound binding / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / cellular response to Thyroglobulin triiodothyronine / estrous cycle / Synthesis of bile acids and bile salts / retinoic acid receptor signaling pathway / Endogenous sterols / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / nuclear retinoid X receptor binding / negative regulation of stem cell proliferation / response to retinoic acid / histone acetyltransferase activity / regulation of cellular response to insulin stimulus / Recycling of bile acids and salts / ヒストンアセチルトランスフェラーゼ / cellular response to hormone stimulus / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / positive regulation of adipose tissue development / peroxisome proliferator activated receptor signaling pathway / RORA activates gene expression / 授乳 / positive regulation of neuron differentiation / Regulation of lipid metabolism by PPARalpha / hormone-mediated signaling pathway / 神経発生 / cerebellum development / BMAL1:CLOCK,NPAS2 activates circadian gene expression / SUMOylation of transcription cofactors / Activation of gene expression by SREBF (SREBP) / nuclear receptor coactivator activity / response to progesterone / stem cell proliferation / nuclear estrogen receptor binding / hippocampus development / nuclear receptor binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / Heme signaling / mRNA transcription by RNA polymerase II / Transcriptional activation of mitochondrial biogenesis / multicellular organism growth / PPARA activates gene expression / Cytoprotection by HMOX1 / cerebral cortex development / Transcriptional regulation of white adipocyte differentiation / Activation of anterior HOX genes in hindbrain development during early embryogenesis / Nuclear Receptor transcription pathway / RNA polymerase II transcription regulator complex / nuclear receptor activity / male gonad development / sequence-specific double-stranded DNA binding / Circadian Clock / response to estradiol / HATs acetylate histones / Estrogen-dependent gene expression / transcription regulator complex / transcription coactivator activity / 細胞分化 / protein dimerization activity / DNA-binding transcription factor activity, RNA polymerase II-specific / positive regulation of apoptotic process / RNA polymerase II cis-regulatory region sequence-specific DNA binding / apoptotic process / chromatin binding / クロマチン / protein-containing complex binding / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / シグナル伝達 / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / zinc ion binding / 核質 / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 : / : / レチノイン酸受容体 / 核内受容体コアクチベーター1 / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator, Ncoa-type, interlocking / Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator / DUF1518 ...: / : / レチノイン酸受容体 / 核内受容体コアクチベーター1 / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator, Ncoa-type, interlocking / Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator / DUF1518 / Nuclear receptor coactivator, receptor-binding domain / Nuclear receptor coactivator / Steroid receptor coactivator / Unstructured region on nuclear receptor coactivator protein / PAS domain / Nuclear receptor coactivator, interlocking / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / PAS fold / PAS fold / PAS domain / PAS repeat profile. / PAS domain / PAS domain superfamily / Retinoid X Receptor / Retinoid X Receptor / 核内受容体 / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-754 / クエン酸 / Retinoic acid receptor beta / 核内受容体コアクチベーター1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
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データ登録者 | le Maire, A. / Teyssier, C. / Germain, P. / Bourguet, W. |
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引用 | ジャーナル: Cells / 年: 2019 タイトル: Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations. 著者: le Maire, A. / Teyssier, C. / Balaguer, P. / Bourguet, W. / Germain, P. |
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履歴 | 登録 | 2019年9月9日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年11月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_initial_refinement_model Item: _citation.country / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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