登録情報 データベース : PDB / ID : 6ru7 構造の表示 ダウンロードとリンクタイトル Crystal structure of Casein Kinase I delta (CK1d) in complex with double phosphorylated p63 PAD2P peptide 要素Casein kinase I isoform delta Tumor protein 63 詳細キーワード TRANSFERASE / CK1 delta / CK1delta / CSNK1D / TP63 / p63 / kinase substrate complex / Structural Genomics / Structural Genomics Consortium / SGC機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
ectoderm and mesoderm interaction / epidermal cell division / cloacal septation / positive regulation of somatic stem cell population maintenance / squamous basal epithelial stem cell differentiation involved in prostate gland acinus development / prostatic bud formation / negative regulation of mesoderm development / female genitalia morphogenesis / positive regulation of non-canonical Wnt signaling pathway / establishment of planar polarity ... ectoderm and mesoderm interaction / epidermal cell division / cloacal septation / positive regulation of somatic stem cell population maintenance / squamous basal epithelial stem cell differentiation involved in prostate gland acinus development / prostatic bud formation / negative regulation of mesoderm development / female genitalia morphogenesis / positive regulation of non-canonical Wnt signaling pathway / establishment of planar polarity / positive regulation of keratinocyte proliferation / negative regulation of keratinocyte differentiation / positive regulation of fibroblast apoptotic process / negative regulation of intracellular estrogen receptor signaling pathway / polarized epithelial cell differentiation / proximal/distal pattern formation / protein localization to Golgi apparatus / positive regulation of cell cycle G1/S phase transition / COPII vesicle coating / skin morphogenesis / cranial skeletal system development / midbrain dopaminergic neuron differentiation / sympathetic nervous system development / microtubule nucleation / post-anal tail morphogenesis / tau-protein kinase / non-motile cilium assembly / protein localization to cilium / embryonic forelimb morphogenesis / Differentiation of keratinocytes in interfollicular epidermis in mammalian skin / embryonic hindlimb morphogenesis / protein localization to centrosome / COPII-mediated vesicle transport / TP53 Regulates Transcription of Death Receptors and Ligands / Activation of PUMA and translocation to mitochondria / hair follicle morphogenesis / Regulation of TP53 Activity through Association with Co-factors / positive regulation of Notch signaling pathway / WW domain binding / tau-protein kinase activity / TP53 Regulates Transcription of Caspase Activators and Caspases / regulation of epidermal cell division / TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain / odontogenesis of dentin-containing tooth / epithelial cell development / positive regulation of stem cell proliferation / Golgi organization / negative regulation of cellular senescence / TP53 Regulates Transcription of Genes Involved in Cytochrome C Release / keratinocyte proliferation / Pyroptosis / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / establishment of skin barrier / spindle assembly / Major pathway of rRNA processing in the nucleolus and cytosol / positive regulation of osteoblast differentiation / Loss of Nlp from mitotic centrosomes / Loss of proteins required for interphase microtubule organization from the centrosome / keratinocyte differentiation / Recruitment of mitotic centrosome proteins and complexes / MDM2/MDM4 family protein binding / Notch signaling pathway / Recruitment of NuMA to mitotic centrosomes / Anchoring of the basal body to the plasma membrane / endoplasmic reticulum-Golgi intermediate compartment membrane / AURKA Activation by TPX2 / ciliary basal body / cellular response to nerve growth factor stimulus / determination of adult lifespan / stem cell proliferation / skeletal system development / spindle microtubule / promoter-specific chromatin binding / TP53 Regulates Metabolic Genes / RNA polymerase II transcription regulatory region sequence-specific DNA binding / protein tetramerization / positive regulation of apoptotic signaling pathway / circadian regulation of gene expression / regulation of circadian rhythm / Wnt signaling pathway / spindle / endocytosis / cellular senescence / Regulation of PLK1 Activity at G2/M Transition / positive regulation of canonical Wnt signaling pathway / p53 binding / Circadian Clock / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / spermatogenesis / DNA-binding transcription activator activity, RNA polymerase II-specific / neuron apoptotic process / transcription by RNA polymerase II / damaged DNA binding / non-specific serine/threonine protein kinase / DNA-binding transcription factor activity, RNA polymerase II-specific / protein kinase activity / cadherin binding / chromatin remodeling / positive regulation of protein phosphorylation / protein phosphorylation 類似検索 - 分子機能 Tumour protein p63, SAM domain / : / p53 family signature. / p53, tetramerisation domain / P53 tetramerisation motif / p53, DNA-binding domain / P53 DNA-binding domain / p53 tumour suppressor family / p53-like tetramerisation domain superfamily / p53/RUNT-type transcription factor, DNA-binding domain superfamily ... Tumour protein p63, SAM domain / : / p53 family signature. / p53, tetramerisation domain / P53 tetramerisation motif / p53, DNA-binding domain / P53 DNA-binding domain / p53 tumour suppressor family / p53-like tetramerisation domain superfamily / p53/RUNT-type transcription factor, DNA-binding domain superfamily / SAM domain (Sterile alpha motif) / p53-like transcription factor, DNA-binding / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 ADENOSINE-5'-DIPHOSPHATE / Casein kinase I isoform delta / Tumor protein 63 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.08 Å 詳細データ登録者 Chaikuad, A. / Tuppi, M. / Gebel, J. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Dotsch, V. / Knapp, S. / Structural Genomics Consortium (SGC) 引用ジャーナル : Nat.Chem.Biol. / 年 : 2020タイトル : p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.著者: Gebel, J. / Tuppi, M. / Chaikuad, A. / Hotte, K. / Schroder, M. / Schulz, L. / Lohr, F. / Gutfreund, N. / Finke, F. / Henrich, E. / Mezhyrova, J. / Lehnert, R. / Pampaloni, F. / Hummer, G. / ... 著者 : Gebel, J. / Tuppi, M. / Chaikuad, A. / Hotte, K. / Schroder, M. / Schulz, L. / Lohr, F. / Gutfreund, N. / Finke, F. / Henrich, E. / Mezhyrova, J. / Lehnert, R. / Pampaloni, F. / Hummer, G. / Stelzer, E.H.K. / Knapp, S. / Dotsch, V. 履歴 登録 2019年5月27日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2020年5月13日 Provider : repository / タイプ : Initial release改定 1.1 2020年8月12日 Group : Database references / Derived calculationsカテゴリ : citation / citation_author ... citation / citation_author / pdbx_struct_conn_angle / struct_conn / struct_conn_type Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id 改定 1.2 2020年9月30日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID 改定 1.3 2024年1月24日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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