Entry Database : PDB / ID : 6q2q Structure visualization Downloads & linksTitle Crystal structure of mouse viperin bound to uridine triphosphate and S-adenosylhomocysteine ComponentsRadical S-adenosyl methionine domain-containing protein 2 Details Keywords IMMUNE SYSTEM / interferon stimulated gene / radical S-adenosylmethionine enzyme / iron sulfur clusterFunction / homology Function and homology informationFunction Domain/homology Component
CD4-positive, alpha-beta T cell activation / Lyases; Carbon-oxygen lyases / positive regulation of toll-like receptor 7 signaling pathway / positive regulation of toll-like receptor 9 signaling pathway / positive regulation of T-helper 2 cell cytokine production / CD4-positive, alpha-beta T cell differentiation / negative regulation of viral genome replication / regulation of ossification / negative regulation of protein secretion / ossification ... CD4-positive, alpha-beta T cell activation / Lyases; Carbon-oxygen lyases / positive regulation of toll-like receptor 7 signaling pathway / positive regulation of toll-like receptor 9 signaling pathway / positive regulation of T-helper 2 cell cytokine production / CD4-positive, alpha-beta T cell differentiation / negative regulation of viral genome replication / regulation of ossification / negative regulation of protein secretion / ossification / lipid droplet / response to virus / fibrillar center / positive regulation of immune response / 4 iron, 4 sulfur cluster binding / defense response to virus / mitochondrial outer membrane / mitochondrial inner membrane / lyase activity / innate immune response / endoplasmic reticulum membrane / Golgi apparatus / endoplasmic reticulum / mitochondrion / metal ion binding Similarity search - Function : / : / 4Fe-4S single cluster domain / Elp3/MiaB/NifB / Elongator protein 3, MiaB family, Radical SAM / Radical SAM superfamily / Radical SAM core domain profile. / Radical SAM / Aldolase-type TIM barrel Similarity search - Domain/homology S-ADENOSYL-L-HOMOCYSTEINE / IRON/SULFUR CLUSTER / URIDINE 5'-TRIPHOSPHATE / S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 Similarity search - ComponentBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.892 Å DetailsAuthors Fenwick, M.K. / Dong, M. / Lin, H. / Ealick, S.E. Funding support United States, 2items Details Hide detailsOrganization Grant number Country Department of Energy (DOE, United States) DE-AC02-06CH11357 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) P30GM124165 United States
CitationJournal : Biochemistry / Year : 2020Title : Structural Basis of the Substrate Selectivity of Viperin.Authors : Fenwick, M.K. / Su, D. / Dong, M. / Lin, H. / Ealick, S.E. History Deposition Aug 8, 2019 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 22, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Jan 29, 2020 Group : Database references / Category : citation / citation_author / Item : _citation.title / _citation_author.identifier_ORCIDRevision 1.2 Feb 26, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID Revision 1.3 Oct 11, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id
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