[English] 日本語
Yorodumi- PDB-6pti: STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR -
+Open data
-Basic information
Entry | Database: PDB / ID: 6pti | ||||||
---|---|---|---|---|---|---|---|
Title | STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR | ||||||
Components | PANCREATIC TRYPSIN INHIBITOR PRECURSOR | ||||||
Keywords | PROTEINASE INHIBITOR (TRYPSIN) | ||||||
Function / homology | Function and homology information trypsinogen activation / negative regulation of serine-type endopeptidase activity / sulfate binding / negative regulation of platelet aggregation / potassium channel inhibitor activity / zymogen binding / molecular function inhibitor activity / negative regulation of thrombin-activated receptor signaling pathway / serine protease inhibitor complex / serine-type endopeptidase inhibitor activity ...trypsinogen activation / negative regulation of serine-type endopeptidase activity / sulfate binding / negative regulation of platelet aggregation / potassium channel inhibitor activity / zymogen binding / molecular function inhibitor activity / negative regulation of thrombin-activated receptor signaling pathway / serine protease inhibitor complex / serine-type endopeptidase inhibitor activity / protease binding / calcium ion binding / extracellular space Similarity search - Function | ||||||
Biological species | Bos taurus (cattle) | ||||||
Method | X-RAY DIFFRACTION / Resolution: 1.7 Å | ||||||
Authors | Wlodawer, A. | ||||||
Citation | Journal: J.Mol.Biol. / Year: 1987 Title: Structure of form III crystals of bovine pancreatic trypsin inhibitor. Authors: Wlodawer, A. / Nachman, J. / Gilliland, G.L. / Gallagher, W. / Woodward, C. #1: Journal: J.Mol.Biol. / Year: 1984 Title: Structure of Bovine Pancreatic Trypsin Inhibitor. Results of Joint Neutron and X-Ray Refinement of Crystal Form II Authors: Wlodawer, A. / Walter, J. / Huber, R. / Sjolin, L. #2: Journal: J.Mol.Biol. / Year: 1987 Title: Comparison of Two Highly Refined Structures of Bovine Pancreatic Trypsin Inhibitor Authors: Wlodawer, A. / Deisenhofer, J. / Huber, R. #3: Journal: J.Mol.Biol. / Year: 1983 Title: Pancreatic Trypsin Inhibitor. A New Crystal Form and its Analysis Authors: Walter, J. / Huber, R. | ||||||
History |
|
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
---|
-Downloads & links
-Download
PDBx/mmCIF format | 6pti.cif.gz | 24.5 KB | Display | PDBx/mmCIF format |
---|---|---|---|---|
PDB format | pdb6pti.ent.gz | 15.6 KB | Display | PDB format |
PDBx/mmJSON format | 6pti.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6pti_validation.pdf.gz | 407.1 KB | Display | wwPDB validaton report |
---|---|---|---|---|
Full document | 6pti_full_validation.pdf.gz | 407.7 KB | Display | |
Data in XML | 6pti_validation.xml.gz | 5.8 KB | Display | |
Data in CIF | 6pti_validation.cif.gz | 7.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/pt/6pti ftp://data.pdbj.org/pub/pdb/validation_reports/pt/6pti | HTTPS FTP |
-Related structure data
Similar structure data |
---|
-Links
-Assembly
Deposited unit |
| ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 |
| ||||||||||||
Unit cell |
| ||||||||||||
Components on special symmetry positions |
|
-Components
#1: Protein | Mass: 6527.568 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Bos taurus (cattle) / References: UniProt: P00974 |
---|---|
#2: Chemical | ChemComp-PO4 / |
#3: Water | ChemComp-HOH / |
-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION |
---|
-Sample preparation
Crystal | Density Matthews: 1.94 Å3/Da / Density % sol: 36.63 % | ||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Crystal grow | *PLUS Temperature: 0 K / pH: 10.13 / Method: batch method | ||||||||||||||||||||||||
Components of the solutions | *PLUS
|
-Data collection
Reflection | *PLUS Highest resolution: 1.7 Å / Num. all: 5753 / Num. obs: 5218 / Num. measured all: 22389 / Rmerge(I) obs: 0.04 |
---|
-Processing
Software | Name: PROLSQ / Classification: refinement | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Refinement | Rfactor obs: 0.16 / Highest resolution: 1.7 Å | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Highest resolution: 1.7 Å
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement | *PLUS Rfactor obs: 0.16 / Highest resolution: 1.7 Å / Num. reflection obs: 4980 / σ(F): 1.5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints | *PLUS
|