SIGNALING PROTEIN / phospholipase / lipase / TIM barrel / Ras-association domain
Function / homology
Function and homology information
Synthesis of IP3 and IP4 in the cytosol / : / regulation of Ras protein signal transduction / phosphoinositide phospholipase C / diacylglycerol biosynthetic process / phosphatidylinositol phospholipase C activity / regulation of G protein-coupled receptor signaling pathway / phospholipase C activity / glomerulus development / regulation of protein kinase activity ...Synthesis of IP3 and IP4 in the cytosol / : / regulation of Ras protein signal transduction / phosphoinositide phospholipase C / diacylglycerol biosynthetic process / phosphatidylinositol phospholipase C activity / regulation of G protein-coupled receptor signaling pathway / phospholipase C activity / glomerulus development / regulation of protein kinase activity / phosphatidylinositol-mediated signaling / positive regulation of lamellipodium assembly / lipid catabolic process / guanyl-nucleotide exchange factor activity / epidermal growth factor receptor signaling pathway / small GTPase binding / lamellipodium / phospholipase C-activating G protein-coupled receptor signaling pathway / Ras protein signal transduction / G protein-coupled receptor signaling pathway / Golgi membrane / enzyme binding / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Ras association (RalGDS/AF-6) domain / Phosphatidylinositol-specific phospholipase C, X domain / Phosphatidylinositol-specific phospholipase C, X domain / Phospholipase C, catalytic domain (part); domain X ...1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Ras association (RalGDS/AF-6) domain / Phosphatidylinositol-specific phospholipase C, X domain / Phosphatidylinositol-specific phospholipase C, X domain / Phospholipase C, catalytic domain (part); domain X / Phosphatidylinositol-specific phospholipase X-box domain profile. / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain / PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily / Ras guanine nucleotide exchange factor domain superfamily / RasGEF domain / Ras guanine-nucleotide exchange factors catalytic domain profile. / Guanine nucleotide exchange factor for Ras-like small GTPases / Ras guanine-nucleotide exchange factors catalytic domain / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain / C2 domain profile. / C2 domain superfamily / EF-hand domain pair / Ubiquitin-like domain superfamily Similarity search - Domain/homology
Resolution: 2.73→20 Å / Cor.coef. Fo:Fc: 0.927 / Cor.coef. Fo:Fc free: 0.9 / SU B: 51.094 / SU ML: 0.42 / Cross valid method: THROUGHOUT / ESU R: 2.22 / ESU R Free: 0.376 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.27278
4196
5 %
RANDOM
Rwork
0.23397
-
-
-
obs
0.23591
80469
99.27 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK