[日本語] English
万見
- PDB-6om3: Crystal structure of the Orc1 BAH domain in complex with a nucleo... -

+
データを開く


IDまたはキーワード:

読み込み中...

-
基本情報

登録情報
データベース: PDB / ID: 6om3
タイトルCrystal structure of the Orc1 BAH domain in complex with a nucleosome core particle
要素
  • DNA (146-MER)
  • DNA (147-MER)
  • Histone H2A
  • Histone H2B 1.1
  • Histone H3.2
  • Histone H4
  • Origin recognition complex subunit 1
キーワードStructural Protein/DNA / Chromatin Modifier / Structural Protein / Structural Protein-DNA complex
機能・相同性
機能・相同性情報


CDC6 association with the ORC:origin complex / maintenance of rDNA / Assembly of the ORC complex at the origin of replication / nuclear origin of replication recognition complex / pre-replicative complex assembly involved in nuclear cell cycle DNA replication / Activation of the pre-replicative complex / nuclear pre-replicative complex / nucleosome organization / DNA replication preinitiation complex / Activation of ATR in response to replication stress ...CDC6 association with the ORC:origin complex / maintenance of rDNA / Assembly of the ORC complex at the origin of replication / nuclear origin of replication recognition complex / pre-replicative complex assembly involved in nuclear cell cycle DNA replication / Activation of the pre-replicative complex / nuclear pre-replicative complex / nucleosome organization / DNA replication preinitiation complex / Activation of ATR in response to replication stress / mitotic DNA replication checkpoint signaling / silent mating-type cassette heterochromatin formation / Orc1 removal from chromatin / DNA replication origin binding / DNA replication initiation / nucleosome binding / structural constituent of chromatin / heterochromatin formation / nucleosome / nucleosome assembly / protein heterodimerization activity / chromatin binding / ATP hydrolysis activity / DNA binding / nucleoplasm / ATP binding / metal ion binding / nucleus
類似検索 - 分子機能
Bromo adjacent homology (BAH) domain / : / Origin recognition complex subunit 1 C-terminal winged HTH domain / AAA lid domain / AAA lid domain / : / Bromo adjacent homology domain / BAH domain / Bromo adjacent homology (BAH) domain / Bromo adjacent homology (BAH) domain superfamily ...Bromo adjacent homology (BAH) domain / : / Origin recognition complex subunit 1 C-terminal winged HTH domain / AAA lid domain / AAA lid domain / : / Bromo adjacent homology domain / BAH domain / Bromo adjacent homology (BAH) domain / Bromo adjacent homology (BAH) domain superfamily / BAH domain profile. / Histone, subunit A / Histone, subunit A / : / Histone H2B signature. / Histone H2A conserved site / Histone H2A signature. / Histone H2B / Histone H2B / Histone H2A, C-terminal domain / C-terminus of histone H2A / Histone 2A / Histone H2A / TATA box binding protein associated factor / TATA box binding protein associated factor (TAF), histone-like fold domain / Histone H4, conserved site / Histone H4 signature. / Histone H4 / Histone H4 / CENP-T/Histone H4, histone fold / Centromere kinetochore component CENP-T histone fold / ATPase family associated with various cellular activities (AAA) / SH3 type barrels. / ATPase, AAA-type, core / Histone H3 signature 1. / Histone H3 signature 2. / Histone H3 / Histone H3/CENP-A / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 domain / Histone-fold / Roll / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / Mainly Beta / Mainly Alpha
類似検索 - ドメイン・相同性
DNA / DNA (> 10) / DNA (> 100) / Histone H2B 1.1 / Histone H2A type 1 / Origin recognition complex subunit 1 / Histone H4 / Histone H3.2 / Histone H2A
類似検索 - 構成要素
生物種Xenopus laevis (アフリカツメガエル)
Saccharomyces cerevisiae (パン酵母)
synthetic construct (人工物)
手法X線回折 / シンクロトロン / 分子置換 / 解像度: 3.3 Å
データ登録者De Ioannes, P.E. / Wang, M. / Armache, K.-J.
資金援助 米国, 2件
組織認可番号国
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)R01GM115882 米国
Other privateThe David and Lucile Packard Foundation 米国
引用ジャーナル: Nat Commun / 年: 2019
タイトル: Structure and function of the Orc1 BAH-nucleosome complex.
著者: De Ioannes, P. / Leon, V.A. / Kuang, Z. / Wang, M. / Boeke, J.D. / Hochwagen, A. / Armache, K.J.
履歴
登録2019年4月18日登録サイト: RCSB / 処理サイト: RCSB
改定 1.02019年7月10日Provider: repository / タイプ: Initial release
改定 1.12019年7月17日Group: Data collection / Database references / カテゴリ: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name
改定 1.22020年1月1日Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization
改定 1.32023年10月11日Group: Data collection / Database references / Refinement description
カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession
改定 1.42024年10月23日Group: Structure summary
カテゴリ: pdbx_entry_details / pdbx_modification_feature

-
構造の表示

構造ビューア分子:
MolmilJmol/JSmol

ダウンロードとリンク

-
集合体

登録構造単位
A: Histone H3.2
B: Histone H4
C: Histone H2A
D: Histone H2B 1.1
E: Histone H3.2
F: Histone H4
G: Histone H2A
H: Histone H2B 1.1
I: DNA (146-MER)
J: DNA (147-MER)
K: Origin recognition complex subunit 1
L: Origin recognition complex subunit 1
M: Histone H3.2
N: Histone H4
O: Histone H2A
P: Histone H2B 1.1
Q: Histone H3.2
R: Histone H4
S: Histone H2A
T: Histone H2B 1.1
U: DNA (146-MER)
V: DNA (147-MER)
W: Origin recognition complex subunit 1
X: Origin recognition complex subunit 1


分子量 (理論値)分子数
合計 (水以外)504,28624
ポリマ－504,28624
非ポリマー00
水00
1
A: Histone H3.2
B: Histone H4
C: Histone H2A
D: Histone H2B 1.1
E: Histone H3.2
F: Histone H4
G: Histone H2A
H: Histone H2B 1.1
I: DNA (146-MER)
J: DNA (147-MER)
K: Origin recognition complex subunit 1
L: Origin recognition complex subunit 1


分子量 (理論値)分子数
合計 (水以外)252,14312
ポリマ－252,14312
非ポリマー00
水0
タイプ名称対称操作数
identity operation1_555x,y,z1
2
M: Histone H3.2
N: Histone H4
O: Histone H2A
P: Histone H2B 1.1
Q: Histone H3.2
R: Histone H4
S: Histone H2A
T: Histone H2B 1.1
U: DNA (146-MER)
V: DNA (147-MER)
W: Origin recognition complex subunit 1
X: Origin recognition complex subunit 1


分子量 (理論値)分子数
合計 (水以外)252,14312
ポリマ－252,14312
非ポリマー00
水0
タイプ名称対称操作数
identity operation1_555x,y,z1
単位格子
Length a, b, c (Å)100.254, 166.428, 168.277
Angle α, β, γ (deg.)90.000, 90.280, 90.000
Int Tables number4
Space group name H-MP1211

-
要素

-
タンパク質 , 5種, 20分子 AEMQBFNRCGOSDHPTKLWX

#1: タンパク質
Histone H3.2


分子量: 15303.930 Da / 分子数: 4 / 変異: G102A / 由来タイプ: 組換発現
由来: (組換発現) Xenopus laevis (アフリカツメガエル)
発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: P84233
#2: タンパク質
Histone H4


分子量: 11394.426 Da / 分子数: 4 / 由来タイプ: 組換発現
由来: (組換発現) Xenopus laevis (アフリカツメガエル)
発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: P62799
#3: タンパク質
Histone H2A


分子量: 14109.436 Da / 分子数: 4 / 変異: G99R, S123A / 由来タイプ: 組換発現
由来: (組換発現) Xenopus laevis (アフリカツメガエル)
遺伝子: hist1h2aj, LOC494591, XELAEV_18003602mg / Variant: ATCC 204508 / S288c / 発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: Q6AZJ8, UniProt: P06897*PLUS
#4: タンパク質
Histone H2B 1.1 / H2B1.1


分子量: 13979.291 Da / 分子数: 4 / 変異: S32T / 由来タイプ: 組換発現
由来: (組換発現) Xenopus laevis (アフリカツメガエル)
発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: P02281
#7: タンパク質
Origin recognition complex subunit 1 / Origin recognition complex 120 kDa subunit


分子量: 26067.488 Da / 分子数: 4 / 変異: L79I / 由来タイプ: 組換発現
由来: (組換発現) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (パン酵母)
株: ATCC 204508 / S288c / 遺伝子: ORC1, YML065W / Variant: ATCC 204508 / S288c
発現宿主: Spodoptera frugiperda (ツマジロクサヨトウ)
参照: UniProt: P54784

-
DNA鎖 , 2種, 4分子 IUJV

#5: DNA鎖 DNA (146-MER)


分子量: 44824.570 Da / 分子数: 2 / 由来タイプ: 合成 / 由来: (合成) synthetic construct (人工物)
#6: DNA鎖 DNA (147-MER)


分子量: 45609.055 Da / 分子数: 2 / 由来タイプ: 合成 / 由来: (合成) synthetic construct (人工物)

-
詳細

Has protein modificationY

-
実験情報

-
実験

実験手法: X線回折 / 使用した結晶の数: 1

-
試料調製

結晶マシュー密度: 2.8 Å3/Da / 溶媒含有率: 60.48 %
結晶化温度: 277.15 K / 手法: 蒸気拡散法, シッティングドロップ法 / pH: 6
詳細: 6 mM Na-Cacodylate pH 6.0, 0.4 mM Spermine-HCl, 2 mM MgCl2 and 1.75% v/v PEG 400

-
データ収集

回折平均測定温度: 110 K / Serial crystal experiment: N
放射光源由来: シンクロトロン / サイト: APS / ビームライン: 24-ID-C / 波長: 0.9791 Å
検出器タイプ: DECTRIS PILATUS 6M-F / 検出器: PIXEL / 日付: 2017年10月29日
詳細: Cryogenically-cooled single crystal Si(220) side bounce monochromator
放射モノクロメーター: Cryo-Cooled double crystal / プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
放射波長波長: 0.9791 Å / 相対比: 1
反射解像度: 3.3→50 Å / Num. obs: 81623 / % possible obs: 97.9 % / 冗長度: 3 % / Biso Wilson estimate: 112.42 Å2 / Rmerge(I) obs: 0.117 / Rpim(I) all: 0.079 / Rrim(I) all: 0.142 / Χ2: 1.264 / Net I/σ(I): 5.2 / Num. measured all: 248201
反射 シェル

Diffraction-ID: 1

解像度 (Å)冗長度 (%)Rmerge(I) obsNum. unique obsCC1/2Rpim(I) allRrim(I) allΧ2% possible all
3.3-3.3630.83740730.4850.5661.0140.51498.1
3.36-3.4230.72740470.5460.490.8810.53798.3
3.42-3.4830.62241160.5990.420.7540.61498.2
3.48-3.5530.53940180.6650.3620.6520.66598
3.55-3.6330.4540540.7240.3070.5470.75497.6
3.63-3.722.90.41540740.7420.2850.5060.78497.3
3.72-3.812.70.35739670.7620.2540.440.97595.9
3.81-3.913.10.30841280.8350.2080.3730.99999
3.91-4.033.20.25441250.890.170.3071.10898.8
4.03-4.163.20.22541150.9010.1510.2731.19399.1
4.16-4.313.20.18941030.9110.1280.2291.33598.8
4.31-4.483.10.16440930.9370.1110.1981.39798.5
4.48-4.683.10.14940560.9450.1020.1811.46397.5
4.68-4.932.90.13340360.9580.0930.1631.596.5
4.93-5.2430.12540400.960.0860.1521.62596.9
5.24-5.643.20.11441030.9610.0770.1381.48998.3
5.64-6.213.20.10241170.9680.0690.1241.48598.5
6.21-7.130.08740960.9770.0610.1071.5597.5
7.1-8.9430.07840990.9790.0530.0942.08197.5
8.94-5030.08141630.9860.0540.0982.98897.3

-
解析

ソフトウェア
名称バージョン分類
PHENIX12-2829精密化
HKL-2000HKL2000_v718-Macデータスケーリング
PDB_EXTRACT3.24データ抽出
HKL-2000HKL2000_v718-Macデータ削減
PHASER2.8.0位相決定
精密化構造決定の手法: 分子置換
開始モデル: 3tu4, 1M4Z, 3LZ1

3tu4

1m4z

3lz1


解像度: 3.3→49.054 Å / SU ML: 0.5 / 交差検証法: THROUGHOUT / σ(F): 1.36 / 位相誤差: 27.11
Rfactor反射数%反射
Rfree0.2497 8111 9.99 %
Rwork0.213 --
obs0.2167 81181 97.81 %
溶媒の処理減衰半径: 0.9 Å / VDWプローブ半径: 1.11 Å
原子変位パラメータBiso max: 381.68 Å2 / Biso mean: 133.4376 Å2 / Biso min: 44.93 Å2
精密化ステップサイクル: final / 解像度: 3.3→49.054 Å
タンパク質核酸リガンド溶媒全体
原子数16894 12012 0 0 28906
残基数----2782
拘束条件
Refine-IDタイプDev ideal数
X-RAY DIFFRACTIONf_bond_d0.00330592
X-RAY DIFFRACTIONf_angle_d0.55543919
X-RAY DIFFRACTIONf_chiral_restr0.0365058
X-RAY DIFFRACTIONf_plane_restr0.0043552
X-RAY DIFFRACTIONf_dihedral_angle_d22.34516292
LS精密化 シェル

Refine-ID: X-RAY DIFFRACTION / Rfactor Rfree error: 0 / Total num. of bins used: 30

解像度 (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkNum. reflection all% reflection obs (%)
3.3-3.33750.33412730.32642440271397
3.3375-3.37670.3552670.32182391265898
3.3767-3.41790.34612690.31492434270398
3.4179-3.46120.34922650.30442427269298
3.4612-3.50670.31942750.29362455273098
3.5067-3.55470.3242720.29172405267798
3.5547-3.60550.30852560.27642449270598
3.6055-3.65930.32532630.29562412267598
3.6593-3.71650.32572750.2842428270397
3.7165-3.77740.29672620.27262386264896
3.7774-3.84250.31742620.26922422268497
3.8425-3.91230.29532770.26562441271899
3.9123-3.98750.27512720.24942448272099
3.9875-4.06890.26692680.24492460272899
4.0689-4.15730.27582840.23822471275599
4.1573-4.2540.2742620.2312433269599
4.254-4.36030.26942810.22872496277799
4.3603-4.47810.27272690.22452399266898
4.4781-4.60980.2532690.21892430269998
4.6098-4.75850.24812590.2112464272397
4.7585-4.92840.24692810.20632354263596
4.9284-5.12550.24922670.20262383265096
5.1255-5.35850.23462800.20952462274299
5.3585-5.64060.2572660.21312443270998
5.6406-5.99350.25482720.21162460273299
5.9935-6.45530.26472800.21792450273098
6.4553-7.10320.26422680.21532439270797
7.1032-8.1270.21772750.17252434270997
8.127-10.22390.20062760.15712465274198
10.2239-49.05980.16892660.152489275597
精密化 TLS

手法: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
19.2358-1.12485.34851.2608-0.36148.57360.35090.752-1.0171-0.446-0.6327-0.94380.55261.059-0.32051.9999-0.4916-0.4157-0.2196-0.00031.2779-84.667910.6122-114.2865
22.1444-0.3866-1.18891.87221.30481.3401-0.8106-0.1020.6176-0.6016-0.50560.19061.5226-0.8209-0.38521.0473-0.2601-0.1971.1580.4660.8403-71.387513.1414-109.7763
35.16150.9164-4.20556.5419-2.32053.83290.0551-0.6078-0.4769-1.46851.33970.31351.9535-0.4061-0.5121.3141-0.1553-0.18450.9460.02850.7246-59.701415.9756-115.8301
43.49980.4561-0.14072.7975-0.16971.54010.25580.7971-0.1389-2.55980.34760.3545-0.06651.3477-0.31391.0994-0.2261-0.08341.0563-0.05840.8855-52.531328.7116-126.0232
56.3698-4.03650.74893.62390.09310.47160.22143.3581-0.4159-2.3759-1.8146-0.6409-0.61870.0499-0.63761.325-0.06520.13480.7321-0.12660.6183-42.517931.2489-126.6821
68.437-1.4659-5.86924.65970.48354.7998-0.807-1.0538-1.67280.09830.28850.86771.13960.2253-0.24360.6975-0.1463-0.17331.1744-0.20460.7846-59.86825.7808-109.4086
71.29930.6479-0.80314.76852.03335.19311.8726-0.20492.78291.04760.04050.4399-0.057-0.57180.35840.4116-0.53580.06661.54190.1511.1099-77.131130.1449-104.7323
84.0928-1.00490.41932.55532.45014.39470.7987-0.12670.9424-1.1922-0.2727-1.9252-1.69951.33470.31550.9349-0.33670.2230.7128-0.32971.6025-64.917937.5182-105.4332
95.21072.7971-6.16991.5254-2.99598.3314-0.03281.0153-0.2415-1.2041-0.1660.22871.13780.0903-0.29841.4598-0.2145-0.33261.15240.35430.8736-56.766630.0568-131.2625
101.95880.2113-1.17883.0539-0.30525.7813-0.59530.9369-0.56070.47111.03160.8470.8155-1.746-0.38960.6788-0.0524-0.21360.81990.23781.0246-70.359122.9497-113.3389
112.60752.9703-0.42733.5109-0.47083.30310.3582.03811.3665-0.54040.3581-0.0873-0.19550.0329-0.57590.78760.03550.05760.84450.0530.7394-49.366233.3532-118.138
126.33050.1119-1.18317.624.10445.7336-0.5449-1.43650.0951-0.14490.3423-0.7874-1.69151.878-0.161.1471-0.2403-0.0420.80.06790.5713-42.640129.6539-110.7701
132.08621.33870.99023.45933.37523.36241.8739-0.6054-0.6039-0.488-1.93170.67271.1357-0.76040.30811.30980.01110.07860.8384-0.00140.7739-46.075623.7504-107.3812
142.8997-1.9153.41356.1857-1.20334.24280.0914-0.211-1.87261.15780.2497-0.46640.3245-1.0328-0.34971.6352-0.52780.06990.5047-0.14520.7411-25.005859.3613-105.6108
155.31475.189-2.68475.1732-2.59051.5161-0.3628-1.778-0.00372.3171-0.9516-3.092-0.64350.9732-0.3850.8878-0.083-0.12731.1002-0.27790.9376-24.668248.7902-99.7666
164.2502-1.8464-0.25623.29752.16986.15951.2846-0.33410.8054-0.8128-0.8824-0.3144-1.3891.0728-0.43420.9217-0.33080.27320.58450.04321.0819-36.514753.4519-104.4714
175.4736-0.286-0.57821.4980.83230.69070.281-0.3890.6033-0.3508-0.05990.1822-0.6817-0.2065-0.04071.0063-0.06540.17420.905-0.2980.9567-57.148154.8166-97.8616
182.9756-0.3526-0.0562.8090.04833.7739-0.4721-0.36130.87010.7349-0.0391-0.9068-1.73380.52590.26581.0405-0.17780.16371.3507-0.03341.3541-32.910860.6342-94.9913
192.1956-0.6055-0.43765.35190.47123.61090.2655-0.28910.0365-0.3150.14620.6871-0.8150.7562-0.26750.8565-0.1782-0.00180.5474-0.08350.7563-36.473447.5094-101.3492
205.9927-0.1609-0.56731.64532.20552.63670.31141.18290.5539-0.4505-0.6101-0.1963-0.50890.12270.30070.8166-0.16090.12080.79920.05590.7818-34.740750.3646-113.9451
211.9795-1.4210.00811.17930.23171.61990.82550.45471.95870.1271-0.24960.8295-1.21570.0294-0.18111.41040.24230.42070.4180.11931.7627-70.101856.8031-85.7554
225.39090.54460.77732.31460.6411.93370.2523-1.9847-0.10921.0195-0.5841-0.204-0.1305-0.7772-0.16231.4273-0.05940.0561.0975-0.11330.5682-48.876640.4968-71.445
236.2924-0.99044.78674.6662-0.71262.4470.34210.72641.1538-0.1341-0.4020.0493-0.77220.4924-0.13910.7268-0.02230.33021.0949-0.18320.8137-63.413343.6219-89.3398
247.8337-0.5313-1.17454.09770.28256.1520.6639-1.1064-0.7150.8903-0.20990.49090.38380.9307-0.41230.83950.00930.0280.8016-0.09760.8002-64.976732.8836-92.4307
251.22230.14091.26290.5533-0.36051.74550.22830.0953-0.5921-0.0974-0.4227-0.0642-0.8583-0.27460.31252.07821.9297-0.6202-1.21450.47470.66-53.726838.6267-62.0477
266.3492-1.80990.57545.49292.87972.05520.2043-0.48830.82520.5599-0.20070.0937-0.6123-2.0837-0.081.13260.10.3171.0658-0.36751.0304-65.088246.8938-79.3705
278.0368-0.67022.21370.6851-1.6682.72550.7675-0.482-2.56850.09220.00981.03220.34990.0346-0.60870.827-0.16420.14030.6209-0.12521.1326-57.533637.8989-81.9681
284.2466-2.30065.31654.0975-1.18497.49710.45-1.19551.0507-0.2744-0.2597-1.02531.0549-0.175-0.58270.743-0.28020.15170.9359-0.20581.0516-40.074140.0916-82.3479
293.0681-1.8128-3.47184.6849-1.05846.64041.2014-0.62160.27650.6104-0.30270.0679-0.55330.0041-0.97751.1702-0.19540.06970.7038-0.03550.837-46.595146.1703-90.4291
300.14050.8194-0.23884.8117-1.11751.7847-0.45880.2172-0.2822-0.31430.1176-1.3050.05660.3162-1.26011.9542-0.32590.06190.32-1.40022.6076-14.68097.5644-92.6059
313.7728-1.7218-2.66394.36592.05672.08860.1957-0.67760.91763.21570.9705-1.6208-1.0821-0.8987-1.07111.65350.4937-0.15621.11750.39581.4529-26.496810.6585-91.4306
324.1745-2.3970.58173.2131-2.40982.4846-0.0858-1.75310.65-1.42260.1875-2.02240.65770.14590.31480.8054-0.0686-0.07121.1091-0.22411.0692-24.688220.9384-97.4828
333.0222-5.503-2.09562.0282.7346.2010.8701-2.3332-1.7637-0.50761.0825-0.6645-0.9653-0.3407-1.13190.7744-0.2609-0.28720.87420.1340.9798-24.224628.8618-94.0207
343.0548-1.986-0.20053.47571.2074.11570.4292-1.0704-1.72990.2549-0.1852-0.96911.9233-0.3084-0.3241.24160.0771-0.16770.54460.2120.7717-41.404211.8988-92.9205
355.28232.01811.81733.4457-3.00485.78320.405-0.6955-0.6056-1.9248-1.48971.29081.8311-0.96030.48941.4133-0.0829-0.48041.029-0.0520.7329-50.54651.8696-104.9632
363.65480.60231.19024.8949-0.07480.56730.7375-0.73820.56280.8395-0.5547-0.46091.2177-0.2708-0.24061.0719-0.1975-0.09080.7029-0.08030.7131-52.728315.7811-96.678
377.71381.36940.34483.1366-1.42513.9012-0.45291.75370.13831.02641.08151.21361.14850.2224-0.13030.9016-0.0568-0.17860.61930.00120.8258-56.055119.0222-102.8774
380.44560.6855-0.18762.14851.25332.03720.854-0.0796-0.2315-1.3455-0.61650.1093-0.2011-0.7805-0.48781.2321-0.0248-0.15090.9850.10541.4405-77.435318.3935-99.2787
393.5408-0.6413-3.8095.64613.03711.99450.46471.55321.7467-2.0767-0.414-0.0761-1.22112.48911.12710.56670.4191-1.18741.70110.69920.3458-28.555815.4606-108.8644
402.5880.4974-3.50897.13060.07111.97780.9825-1.1617-0.790.60890.8806-1.35291.0312-1.3643-1.28981.27790.0977-0.25190.72210.19191.0246-36.20075.3517-98.6799
414.8034-0.3029-2.25670.087-0.05234.9332-0.1923-0.3525-1.7905-1.3073-1.49890.18161.5583-0.35880.05211.55230.0492-0.12561.01060.16280.8098-43.67270.9997-100.8579
424.58131.45491.07253.5135-0.90924.27070.05230.24490.4499-1.0392-0.4230.0365-0.57960.29340.29850.48590.05010.0210.69050.00240.7716-37.477324.2594-97.5352
434.81960.3674-0.97991.97160.95771.91280.5245-0.84670.22470.9959-1.8854-0.88870.60960.823-0.21481.1827-0.0156-0.28241.261-0.16891.105-25.943534.2318-85.7313
442.12582.77090.97868.99420.4367.77151.2518-0.3641.01320.7724-0.64-0.080.4502-0.4209-0.24760.7239-0.12240.04830.7007-0.10120.7475-37.088426.0328-85.0509
451.57150.21390.94455.50620.53290.6160.9769-1.2829-0.40132.5102-0.8620.7926-0.190.2378-0.33360.88360.3181-0.29641.59290.38860.3815-33.481415.0624-82.6936
461.64610.51870.24991.9158-0.07362.1570.2923-0.4049-0.04030.1666-0.05210.20030.2972-0.0918-0.24091.0679-0.1065-0.02581.00550.12580.8555-55.280125.2329-95.918
474.47820.8633-0.33443.08730.38241.68820.5591-0.22250.56020.0585-0.0456-0.4768-0.2730.4733-0.41441.09740.0797-0.02430.90090.39720.4527-39.873850.2801-102.8555
48-0.18620.00060.14972.1109-0.00690.0425-0.30040.0498-0.08070.52450.11730.2929-0.71030.06870.14812.0202-0.0590.04751.3755-0.18631.3824-53.389170.3522-86.6124
493.68250.3551-0.70632.41770.97732.5749-0.22550.1179-0.1947-0.280.24530.2170.18650.1355-0.02691.04520.1337-0.10430.6830.35430.7714-57.003632.3182-109.8382
502.8117-0.1360.73232.03260.17070.8088-0.2411-0.40861.09540.84930.3472-0.9558-0.171.1274-0.33211.5732-0.3105-0.26181.6305-0.04351.1895-25.298438.9974-77.9075
512.65313.0291-1.19062.29540.35741.32-0.46550.5644-0.8328-0.68110.4094-0.42450.61960.01560.00861.84460.0426-0.23451.08620.15130.8551-57.0792-0.6537-112.3663
521.719-1.9568-0.31754.0615-0.46583.9981-1.365-0.2677-0.68571.09420.7083-0.05680.3005-0.79380.371.12240.007-0.06290.9135-0.02761.1823-36.833657.0198-128.8396
530.5117-1.00481.43812.9152-1.6354.1558-0.04480.1591-0.1082-0.8866-0.3648-0.3794-0.0532-0.52420.29260.9884-0.14860.05540.64420.02560.778-41.091755.373-131.4606
541.56661.64983.02664.21780.3643.88910.38680.45120.28670.3696-0.0560.0752-0.0481-0.1903-0.27050.7745-0.05350.09110.8330.0170.7911-43.11944.5597-139.4564
550.6378-1.02120.4581.8096-1.36875.9991-0.46812.2436-0.1379-0.0064-0.73750.6376-0.4416-0.64120.04471.1350.374-0.09851.18240.21490.9519-54.179254.5945-152.7541
565.7229-1.9425-0.29564.06810.98780.32090.9982-0.1372-0.54010.3123-1.59740.3182-0.91631.3604-0.04821.1829-0.1256-0.0121.35440.30640.7107-49.988751.0797-153.0595
573.65542.17952.61866.11144.60863.87510.4953-0.5362-0.496-0.3028-0.85970.4905-0.1876-1.76030.22591.0708-0.01990.11771.23110.18261.3042-57.364345.2608-137.2361
583.71441.5802-3.42147.443-1.53554.6594-0.06150.07560.34311.08261.18910.8581-0.0421.8991-0.03031.5940.2624-0.2481.3328-0.0710.6423-31.801216.1846-66.9405
591.9629-0.64620.02595.0453-4.54338.84910.65590.0380.6179-1.90040.30020.4329-0.60050.0053-0.2330.9592-0.0821-0.19210.80470.11211.445-45.14777.2231-78.1246
602.0602-0.6132-1.70047.06961.35371.91350.0144-0.91440.184-1.10670.46260.1777-0.34850.95650.69841.76850.108-0.11061.5520.0150.986-40.317814.2647-59.9968
613.617-3.0027-4.37954.87070.73339.07280.2956-0.61730.20060.1893-0.57640.1213-1.55480.65030.21091.5016-0.1467-0.2111.29560.07850.7949-41.041725.3551-62.9239
62-0.0702-0.4079-0.16562.78941.3931.5907-0.7294-0.001-0.5899-0.45870.80210.99530.3408-0.74650.01042.0461-0.25320.22741.38910.11240.8111-55.189635.1857-44.7537
633.81230.198-2.60221.20320.29581.97280.61281.90.47060.793-0.02220.2486-0.1858-1.45981.35943.1287-0.64130.06931.2424-0.14710.0873-54.164537.6912-35.6091
643.00010.4207-2.8797-0.0307-0.43422.5739-1.05482.30540.65371.3547-0.06280.19922.1163-2.58920.18992.0016-0.15110.18151.36550.16931.1304-48.765727.3791-52.2828
652.6104-2.1402-0.5432.2631-0.83473.8247-0.0814-0.71011.17752.8556-0.40680.42680.65761.81650.12772.9022-0.38610.07530.9374-0.35130.7341-46.213717.433-50.1861
663.987-3.20291.07458.7952-3.22996.27240.54642.2224-0.05672.964-0.56282.57910.14780.57440.2132.0437-0.02460.08361.27450.22641.1032-50.509319.0354-44.6479
676.3189-1.0731-0.66631.27781.43936.2894-0.94220.5818-0.5590.8941-0.9322-0.0426-0.2977-1.4933-0.26881.9464-0.22260.481.0941-0.00881.6644-59.078531.1625-53.1792
688.3392-4.13852.0476.0106-0.81240.4903-0.29840.4859-1.2076-1.08911.0823-0.6310.94680.5115-0.22392.5135-0.63080.13431.7366-0.30981.7087-56.221716.1152-60.0761
690.8972-1.2251-0.01311.65160.16240.1403-0.19570.0731-0.4848-0.8256-0.74540.0906-0.6683-0.3558-0.3661.5366-0.2826-0.16531.1634-0.21381.1377-58.641225.9315-65.7001
705.10622.31921.08043.5577-2.72244.70271.09880.25521.3765-0.20120.80040.78090.80850.0128-2.19010.7520.4028-0.08871.3316-0.07181.413332.3621.85828.6277
714.4862-3.3681.96763.5188-0.153.076-0.79290.1082-2.03360.3871-0.4667-0.74512.48560.7180.59150.88070.00630.0460.77110.240.859119.029424.47871.2592
725.07650.1307-3.11622.78981.23832.4362-0.2853-0.6893-0.19380.64960.4547-0.0978-0.2020.8907-0.03650.61640.0756-0.10831.30130.18660.7478-1.471140.15110.3296
738.7343-1.3998-2.92042.8017-0.82172.9066-0.15450.5092-1.6258-0.0958-0.0982-0.36930.234-0.28880.37640.54370.07260.03740.86480.08940.91338.712437.6916-2.2012
743.5649-0.06170.39464.26371.28464.57460.49110.70762.21011.10060.5744-0.2748-0.75580.60780.47940.6130.29190.18181.09520.32341.041126.969540.3739-4.4904
755.6687-2.32481.88272.8699-1.92038.47940.10560.15321.54840.12780.38920.3614-1.0782-0.26560.55360.80080.1075-0.20570.58010.2910.872215.434348.249-6.678
762.1891-2.9754-2.95744.36084.3145.3023-1.74140.30690.28391.9003-0.1187-1.82240.37822.44521.24951.52580.17310.07692.21090.30281.4693-0.234446.951922.1661
771.94420.47960.79662.79170.95073.4485-0.1404-0.3601-0.73770.3763-0.2240.29060.79030.81980.24110.54980.0451-0.0981.21040.17870.71613.060236.07737.8171
784.29850.2752-1.26372.0649-0.78332.0611-0.2209-0.18130.71070.34460.295-0.2423-0.3965-0.09110.00640.49910.0328-0.07080.74010.03280.59772.381545.12863.6541
797.6023-3.0926-1.29239.82192.2047.71140.16481.5294-1.0342-0.3835-0.5411.6028-1.0891-0.70370.48690.61710.0083-0.07590.6652-0.08820.7641-6.662840.1957-4.8614
806.1002-5.5355-5.45954.98644.90884.9066-0.64091.34150.65610.1140.53250.0866-1.9234-0.5163-0.28841.18620.19810.03341.11930.10681.3678-23.583274.1881-15.0338
811.0603-1.73380.27173.7492-1.09860.5514-0.4557-0.131-0.4339-1.17452.51122.2413-0.4329-1.4702-0.69980.719-0.1693-0.26881.07670.13570.7716-22.288262.1974-19.2886
825.5105-0.4418-3.73738.1160.62074.68370.1723-0.26840.74430.50371.7624-0.67091.3556-0.1606-1.38060.5107-0.0214-0.16010.6895-0.22010.9194-24.469154.3078-15.3911
833.75241.0279-4.23662.3237-3.20856.42720.8748-1.08141.51650.618-0.89081.3065-0.94891.17510.08270.65130.04990.03010.6230.09641.0423-5.619271.0006-12.8143
841.99486.46270.54225.98950.7870.1289-1.16430.4104-3.34250.09441.4264-1.8213-1.7253-0.14130.09861.0787-0.1883-0.15951.25830.34191.00415.98678.5662-24.0793
853.57731.4-1.40866.6001-2.14191.56550.02140.9089-1.3541.33230.29510.83560.1164-0.1236-0.23910.47170.2130.1460.85030.34290.82646.997767.8871-18.2471
866.47881.18861.92875.0649-3.89494.040.2095-0.16340.1272-0.48150.0893-0.25580.31290.8971-0.01480.42870.0411-0.02010.79390.05030.70147.079161.6341-16.1461
879.61671.23995.38674.124-1.80564.658-1.75430.111.54962.3775-0.89041.7209-0.1608-0.7180.83541.0658-0.23680.36261.08650.06050.8430.338361.3852-12.9519
884.2788-2.6684-0.65733.2232-0.45746.7755-0.02760.95170.2977-0.71850.0415-0.2142-1.3479-0.19740.02690.5810.01150.1520.8560.080.7287-9.333574.892-22.913
893.64845.7487-2.33437.5582-3.14793.9008-0.42580.5853-0.7193-2.0080.3611-0.10660.7284-0.5680.19120.60960.1219-0.03580.60650.02990.6472-9.940158.2128-17.1894
907.97490.19972.06763.1497-1.41978.27320.4237-0.57150.17341.3135-2.03060.60490.21530.61221.82010.8865-0.137-0.07460.7190.04520.8997-24.078149.9386-6.4233
915.0467-2.6693-2.15473.2189-1.34234.15930.42220.2014-0.77130.286-0.36780.52720.1376-0.0521-0.08810.5361-0.02120.03240.80350.01280.8288-12.608757.626-4.4931
924.6075-0.4838-0.35194.4307-0.00932.3272-0.7397-1.1714-1.01330.43151.3607-0.0809-1.1547-0.5988-0.14840.80880.3334-0.13291.28140.07790.7857-15.33768.802-3.4954
938.4381.7426-0.32991.62661.16184.3016-0.83790.7771-0.1785-1.06650.5471-0.5161-0.38620.55070.63790.88950.06190.13410.72160.10230.833919.339959.6376-32.132
949.35531.77093.80383.52510.133.60010.4415-0.87430.1624-0.362-0.4632-0.25730.5819-0.36410.00020.5615-0.04140.19740.5712-0.04870.616114.034149.5325-25.3265
956.6716-1.55436.26470.3457-1.44275.87160.58083.3005-2.4821-2.25361.3291-1.1524-0.02791.6515-0.26881.04490.11690.37211.7625-0.22161.171717.002547.9477-41.4579
965.11381.23234.55130.63630.61915.7088-0.00171.23730.5895-0.6687-0.0695-0.9169-1.03551.66180.39040.70590.11020.15040.87670.18690.830624.459856.4321-27.2024
977.39611.81671.24483.51451.18380.32620.33070.4127-1.5577-0.4742-0.2316-0.45450.67950.20940.2090.88320.09030.07050.66370.07180.59834.516346.0408-34.1896
987.8676-0.6674-3.37833.3264-3.71767.51780.3216-2.41431.7732-0.0481.08610.89760.49890.0398-1.33950.43470.0815-0.07940.9595-0.0010.5257-4.032351.5077-28.9329
992.64062.0464-3.62012.1171-1.88066.32271.1026-0.20590.3169-2.501-0.9737-0.80560.52071.83330.53741.09990.08490.09921.0870.00140.58740.02155.6411-25.1038
1002.24570.4054-3.5230.843-1.38156.4316-1.9009-0.1033-0.69030.6183-1.2228-0.41980.33471.06760.14691.0762-0.3835-0.34080.79480.21091.6773-25.88922.8366-23.5894
1012.0842-0.0176-2.36327.314-0.87652.831-1.06040.269-0.4303-0.5848-0.16021.17310.4642-1.251-0.52630.5583-0.0011-0.17781.00190.07341.1323-24.465834.3828-18.629
1028.2694-1.2939-0.04748.20621.00345.22791.2980.23560.7263-0.0629-0.74090.52240.02021.4193-0.30521.1330.15860.14210.63580.15561.1506-24.03342.337-23.2594
1031.91560.06061.35732.2835-0.81043.86530.5869-0.1404-0.8119-1.5373-0.1238-0.33591.375-0.0961-0.41210.6501-0.1822-0.00740.5215-0.06750.8269-8.090122.9988-19.9461
1042.2724-3.28291.58715.216-2.02631.2509-0.4213-1.9036-0.47210.82980.30750.61990.63691.63540.02460.99940.2450.07941.24850.3071.2905-1.292213.9608-5.4698
1054.8856-0.9699-0.00154.8046-0.43846.91140.0562-0.3766-0.2101-0.5147-0.2884-0.1212-0.93351.68480.38010.5811-0.04830.00030.60510.03170.78942.701126.9076-14.8323
1068.4017-2.18931.71666.5033-0.24242.2735-0.68420.5882-1.11461.79030.075-0.7717-1.20640.45810.42590.7460.0274-0.32160.835-0.08220.69040.61332.8424-8.395
1072.8104-0.05440.24680.36520.38040.4031-0.325-0.06090.2345-0.80960.0983-0.7942-0.01370.0474-0.177-0.66721.26050.4104-0.3831-0.51.817213.877226.7589-8.6084
1082.56683.26761.34818.44384.47032.477-0.7777-0.5778-0.20961.7717-0.93351.37920.45340.453-1.34971.2858-0.0780.28940.820.29680.746127.307727.8219-8.6638
1097.85286.8328-6.63237.2514-5.66725.59551.63231.01380.54940.415-0.41631.49850.30321.1666-0.48630.65240.0995-0.31831.504-0.00491.2999-22.629429.7222-6.7701
1107.4971-5.35341.14383.9804-1.60028.2657-0.32460.5402-1.03661.69351.25310.80621.3524-2.144-0.32830.794-0.11660.03990.54830.20061.2638-14.792817.9929-14.5995
1115.4235-0.7692-1.82240.5368-1.40727.01330.441.2069-1.404-0.055-0.4811.05610.8007-0.2216-0.73540.9150.36010.25281.10080.28582.3969-7.940913.5359-11.0057
1120.2506-1.0878-0.01123.438-2.53136.5019-0.3538-0.1437-0.554-0.42190.0289-0.0802-0.3019-0.83070.24320.5161-0.0491-0.20370.82490.01840.781-11.617536.6456-17.1235
1130.7297-0.13380.27522.1158-1.78351.4694-0.7746-1.70730.5168-1.2222-1.4479-0.933-0.8837-0.72721.09521.28280.2851-0.20070.80550.06150.7975-20.293746.2381-31.2083
1141.02311.6555-0.47315.48120.05046.3140.1441.9109-0.9513-1.9085-0.0372-0.1494-0.5081.1337-0.09030.8406-0.1002-0.20960.9296-0.16770.7437-9.754436.8975-29.7197
1156.18860.75063.06697.86781.92634.62330.26531.4655-1.3919-0.7941.6337-0.81861.38150.9067-1.47221.1809-0.2216-0.36671.1686-0.13070.8503-14.846525.9897-31.6392
116-0.0557-0.43870.25415.7144-0.82511.1248-0.77720.18720.32250.18330.3079-0.74630.1025-0.17770.18861.02530.0022-0.08821.12880.05441.657611.4959.61385.692
1173.25261.0849-0.47212.2281-0.94272.0107-0.18270.89110.1303-0.80510.18670.23340.1396-0.26180.0451.11510.08340.14790.7357-0.380.7937-5.276347.5828-34.3376
1182.0303-0.6357-0.62281.7827-1.05472.5236-0.0983-0.5053-0.2620.3370.01680.0477-0.06020.30990.02290.9024-0.0795-0.01060.9664-0.04850.94072.866236.785610.2905
1190.83520.3192.2163.5332-1.44663.5095-0.55831.09081.3939-0.65540.27320.0519-0.27410.2696-0.10891.04720.25250.13620.9686-0.06290.90321.100876.6338-28.3898
1202.34091.2420.63732.3246-0.85070.3292-0.36781.14421.4866-0.3583-0.0097-0.0721-0.28790.35590.23421.4701-0.02280.11051.56940.16231.24799.617380.1854-29.7862
1211.5352-0.5478-1.90583.2148-1.51161.62590.11560.5657-0.38430.310.49251.5233-0.1982-0.6632-0.35650.9231-0.18930.03451.5330.0541.3738-33.602750.5001-1.3573
1221.4274-1.87651.21441.7653-0.94633.4869-0.2975-0.99180.02440.28840.0266-0.5670.04360.66320.3110.952-0.0109-0.08111.40050.12041.231124.072335.80068.5176
1236.07041.12382.65311.88090.02472.1379-0.35541.54021.2483-1.1454-0.07690.2813-0.07560.41680.38791.6430.09420.06381.04840.19431.09674.198558.8429-45.8966
1244.2533-1.7671-1.70543.5309-0.93091.5243-0.1873-0.1465-0.90940.90520.24610.9288-0.5345-0.51710.12450.7593-0.2563-0.15231.5377-0.12841.3554-30.596324.5677-10.7588
1253.31373.2053-0.38112.78710.68734.0701-1.0898-0.2574-1.1421-0.48490.478-1.09350.60230.75080.60251.0829-0.014-0.02960.98030.06421.654918.79610.35435.6154
1262.87-1.44290.4451.771-1.0825.3325-0.0946-0.0560.58141.28910.25991.0636-1.1328-0.1273-0.01741.2477-0.02840.40070.694-0.23591.5159-12.711673.68848.2573
1270.64450.35310.09360.21690.02086.8746-0.4471-1.1393-0.79241.01710.0774-0.6278-1.2180.96050.47931.5450.01610.3410.8518-0.05651.6277-8.673574.347810.35
1285.3306-2.5925-1.78542.35790.45822.42890.27340.18790.39352.15490.47140.43390.5540.91710.0522.0555-0.327-0.10481.55780.06840.716-13.726664.095324.8632
1293.26290.8182-0.66962.7141-0.61250.24520.1680.2228-1.54070.3267-0.8621-1.14611.4226-0.0847-0.00791.2507-0.222-0.00261.32340.09410.9083-8.404962.859418.6322
1304.41331.09291.2232.9432.64962.71561.0017-1.2361-0.47420.0553-0.31770.09211.5608-0.63080.36130.96330.13610.11831.1975-0.05880.6852-12.239360.240511.7523
1310.65030.34180.45235.4489-2.03921.27520.4466-1.0757-0.0561.95971.20850.6044-1.097-0.2269-1.32782.1572-0.6475-0.082.1294-0.26870.7241-1.004152.004138.9666
1323.0848-0.4255-1.18322.72980.73976.3533-0.4362-1.5970.4359-1.9386-0.2556-1.5278-0.4563-3.4004-0.55261.5379-0.3587-0.00192.50110.07770.8824-4.369155.891239.3508
1331.8507-2.15990.79322.8862-0.72181.9888-0.13410.73210.27121.4270.11220.4083-1.0141-0.43250.09141.4890.01650.03871.2572-0.17630.9602-15.982762.784821.2579
1341.66080.11781.03050.41241.08793.12830.2241-1.2061.90060.8928-1.3467-2.0282-0.3870.5617-3.35441.5899-3.0222-1.50760.2945-0.6191.7014-2.237272.063237.275
1353.7426-2.354-1.98743.6553-0.94063.27650.81060.34452.59631.04690.0341-0.9083-4.95411.3926-0.56982.1709-0.01840.18431.5957-0.04770.8116-5.83767.518336.5707
1364.13241.6086-1.87853.26791.21442.24430.6911-1.0525-1.2411-0.66690.291.19711.5437-1.12790.09491.1654-0.1836-2.18412.6066-0.48190.34793.318153.117431.553
1373.13280.32160.44621.13590.11770.17541.5608-1.58391.83321.3599-1.60420.43340.0657-0.2798-0.87563.3542-0.87370.9210.5005-0.72771.67423.586567.825720.9405
1382.72110.645-1.20013.6680.89684.5153-0.8670.0760.10850.1146-0.2859-0.21160.4376-0.19260.31541.3506-0.06350.18351.70620.01730.95155.61157.761518.591
1395.51743.74491.3553.8794-1.05813.4452-1.12785.12291.877-2.68221.6568-1.34190.40180.6450.63721.9559-0.3249-0.51361.49260.5181.3621-13.384725.3502-46.0756
1400.09890.58520.1787.49994.3273.01410.0332-0.6578-0.4184-0.8313-0.7642-0.8623-0.2892-1.22120.81241.504-0.5153-0.59841.19580.26221.063-2.298816.7266-33.7885
1411.9996-5.3109-9.17544.75446.26389.0610.1992-3.4408-1.01582.27610.7649-0.64680.73141.2321-0.06682.29740.09330.31661.1950.56081.5074-4.771221.2637-44.2873
1428.2974-1.32623.69250.98821.07665.15450.41320.4235-1.90461.1365-1.31611.69590.4446-0.2066-1.60132.8283-0.6993-0.25081.011-0.51711.3663-7.859116.7638-54.3604
1436.80945.14612.02335.5989-2.11347.8776-0.20781.4629-0.0304-1.48211.7517-0.61120.04831.488-0.6563.30270.1718-0.14271.32440.18140.5662-1.148729.4012-57.1994
1444.70063.4843-2.02723.0329-2.07365.6623-0.8165-2.4432-0.1617-1.3926-0.6511-0.026-1.69791.74730.74162.1725-0.1681-0.11051.5492-0.2561.1571-3.227332.7579-45.6744
1452.7735-2.6697-2.79197.4303-0.73585.24020.69811.925-1.4976-2.51251.30930.35670.87481.3344-0.91022.0536-0.1725-0.58091.7925-0.40410.8099-3.579734.9937-53.1372
146-0.0061-0.20990.01553.72460.7740.105-1.07890.96960.546-2.51880.0842-0.88440.0872-0.163-3.46472.44890.1530.20941.3732-1.1340.07834.595525.2142-62.4041
1478.22712.9587-0.36861.0341-0.11720.01110.0248-1.71293.76170.0881-0.92781.1221-0.4265-0.1856-0.75563.6120.65390.13691.0118-0.49051.79269.967123.0366-46.5353
1483.5566-3.0284-2.15444.73465.63739.05051.0747-0.1087-0.4551.9551-0.32611.87571.28622.7931-0.14342.426-0.0980.41011.3868-0.14241.589212.41634.1711-44.7961
精密化 TLSグループ
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain 'A' and (resid 38 through 44 )A38 - 44
2X-RAY DIFFRACTION2chain 'A' and (resid 45 through 55 )A45 - 55
3X-RAY DIFFRACTION3chain 'A' and (resid 56 through 63 )A56 - 63
4X-RAY DIFFRACTION4chain 'A' and (resid 64 through 77 )A64 - 77
5X-RAY DIFFRACTION5chain 'A' and (resid 78 through 85 )A78 - 85
6X-RAY DIFFRACTION6chain 'A' and (resid 86 through 113 )A86 - 113
7X-RAY DIFFRACTION7chain 'A' and (resid 114 through 120 )A114 - 120
8X-RAY DIFFRACTION8chain 'A' and (resid 121 through 134 )A121 - 134
9X-RAY DIFFRACTION9chain 'B' and (resid 18 through 30 )B18 - 30
10X-RAY DIFFRACTION10chain 'B' and (resid 31 through 49 )B31 - 49
11X-RAY DIFFRACTION11chain 'B' and (resid 50 through 82 )B50 - 82
12X-RAY DIFFRACTION12chain 'B' and (resid 83 through 93 )B83 - 93
13X-RAY DIFFRACTION13chain 'B' and (resid 94 through 101 )B94 - 101
14X-RAY DIFFRACTION14chain 'C' and (resid 15 through 26 )C15 - 26
15X-RAY DIFFRACTION15chain 'C' and (resid 27 through 35 )C27 - 35
16X-RAY DIFFRACTION16chain 'C' and (resid 36 through 72 )C36 - 72
17X-RAY DIFFRACTION17chain 'C' and (resid 73 through 118 )C73 - 118
18X-RAY DIFFRACTION18chain 'D' and (resid 32 through 48 )D32 - 48
19X-RAY DIFFRACTION19chain 'D' and (resid 49 through 90 )D49 - 90
20X-RAY DIFFRACTION20chain 'D' and (resid 91 through 124 )D91 - 124
21X-RAY DIFFRACTION21chain 'E' and (resid 40 through 63 )E40 - 63
22X-RAY DIFFRACTION22chain 'E' and (resid 64 through 85 )E64 - 85
23X-RAY DIFFRACTION23chain 'E' and (resid 86 through 120 )E86 - 120
24X-RAY DIFFRACTION24chain 'E' and (resid 121 through 134 )E121 - 134
25X-RAY DIFFRACTION25chain 'F' and (resid 18 through 24 )F18 - 24
26X-RAY DIFFRACTION26chain 'F' and (resid 25 through 40 )F25 - 40
27X-RAY DIFFRACTION27chain 'F' and (resid 41 through 75 )F41 - 75
28X-RAY DIFFRACTION28chain 'F' and (resid 76 through 93 )F76 - 93
29X-RAY DIFFRACTION29chain 'F' and (resid 94 through 100 )F94 - 100
30X-RAY DIFFRACTION30chain 'G' and (resid 12 through 16 )G12 - 16
31X-RAY DIFFRACTION31chain 'G' and (resid 17 through 26 )G17 - 26
32X-RAY DIFFRACTION32chain 'G' and (resid 27 through 35 )G27 - 35
33X-RAY DIFFRACTION33chain 'G' and (resid 36 through 46 )G36 - 46
34X-RAY DIFFRACTION34chain 'G' and (resid 47 through 72 )G47 - 72
35X-RAY DIFFRACTION35chain 'G' and (resid 73 through 79 )G73 - 79
36X-RAY DIFFRACTION36chain 'G' and (resid 80 through 96 )G80 - 96
37X-RAY DIFFRACTION37chain 'G' and (resid 97 through 111 )G97 - 111
38X-RAY DIFFRACTION38chain 'G' and (resid 112 through 118 )G112 - 118
39X-RAY DIFFRACTION39chain 'H' and (resid 32 through 37 )H32 - 37
40X-RAY DIFFRACTION40chain 'H' and (resid 38 through 48 )H38 - 48
41X-RAY DIFFRACTION41chain 'H' and (resid 49 through 55 )H49 - 55
42X-RAY DIFFRACTION42chain 'H' and (resid 56 through 83 )H56 - 83
43X-RAY DIFFRACTION43chain 'H' and (resid 84 through 90 )H84 - 90
44X-RAY DIFFRACTION44chain 'H' and (resid 91 through 103 )H91 - 103
45X-RAY DIFFRACTION45chain 'H' and (resid 104 through 124 )H104 - 124
46X-RAY DIFFRACTION46chain 'I' and (resid 2 through 91 )I2 - 91
47X-RAY DIFFRACTION47chain 'I' and (resid 92 through 147 )I92 - 147
48X-RAY DIFFRACTION48chain 'J' and (resid 1 through 30 )J1 - 30
49X-RAY DIFFRACTION49chain 'J' and (resid 31 through 90 )J31 - 90
50X-RAY DIFFRACTION50chain 'J' and (resid 91 through 120 )J91 - 120
51X-RAY DIFFRACTION51chain 'J' and (resid 121 through 147 )J121 - 147
52X-RAY DIFFRACTION52chain 'K' and (resid 2 through 21 )K2 - 21
53X-RAY DIFFRACTION53chain 'K' and (resid 22 through 65 )K22 - 65
54X-RAY DIFFRACTION54chain 'K' and (resid 66 through 149 )K66 - 149
55X-RAY DIFFRACTION55chain 'K' and (resid 150 through 160 )K150 - 160
56X-RAY DIFFRACTION56chain 'K' and (resid 161 through 177 )K161 - 177
57X-RAY DIFFRACTION57chain 'K' and (resid 178 through 213 )K178 - 213
58X-RAY DIFFRACTION58chain 'L' and (resid 2 through 16 )L2 - 16
59X-RAY DIFFRACTION59chain 'L' and (resid 17 through 37 )L17 - 37
60X-RAY DIFFRACTION60chain 'L' and (resid 38 through 58 )L38 - 58
61X-RAY DIFFRACTION61chain 'L' and (resid 59 through 89 )L59 - 89
62X-RAY DIFFRACTION62chain 'L' and (resid 90 through 116 )L90 - 116
63X-RAY DIFFRACTION63chain 'L' and (resid 117 through 126 )L117 - 126
64X-RAY DIFFRACTION64chain 'L' and (resid 127 through 142 )L127 - 142
65X-RAY DIFFRACTION65chain 'L' and (resid 143 through 160 )L143 - 160
66X-RAY DIFFRACTION66chain 'L' and (resid 161 through 177 )L161 - 177
67X-RAY DIFFRACTION67chain 'L' and (resid 178 through 188 )L178 - 188
68X-RAY DIFFRACTION68chain 'L' and (resid 189 through 198 )L189 - 198
69X-RAY DIFFRACTION69chain 'L' and (resid 199 through 213 )L199 - 213
70X-RAY DIFFRACTION70chain 'M' and (resid 37 through 44 )M37 - 44
71X-RAY DIFFRACTION71chain 'M' and (resid 45 through 55 )M45 - 55
72X-RAY DIFFRACTION72chain 'M' and (resid 56 through 85 )M56 - 85
73X-RAY DIFFRACTION73chain 'M' and (resid 86 through 113 )M86 - 113
74X-RAY DIFFRACTION74chain 'M' and (resid 114 through 120 )M114 - 120
75X-RAY DIFFRACTION75chain 'M' and (resid 121 through 134 )M121 - 134
76X-RAY DIFFRACTION76chain 'N' and (resid 18 through 24 )N18 - 24
77X-RAY DIFFRACTION77chain 'N' and (resid 25 through 40 )N25 - 40
78X-RAY DIFFRACTION78chain 'N' and (resid 41 through 82 )N41 - 82
79X-RAY DIFFRACTION79chain 'N' and (resid 83 through 101 )N83 - 101
80X-RAY DIFFRACTION80chain 'O' and (resid 12 through 26 )O12 - 26
81X-RAY DIFFRACTION81chain 'O' and (resid 27 through 35 )O27 - 35
82X-RAY DIFFRACTION82chain 'O' and (resid 36 through 46 )O36 - 46
83X-RAY DIFFRACTION83chain 'O' and (resid 47 through 72 )O47 - 72
84X-RAY DIFFRACTION84chain 'O' and (resid 73 through 79 )O73 - 79
85X-RAY DIFFRACTION85chain 'O' and (resid 80 through 89 )O80 - 89
86X-RAY DIFFRACTION86chain 'O' and (resid 90 through 111 )O90 - 111
87X-RAY DIFFRACTION87chain 'O' and (resid 112 through 118 )O112 - 118
88X-RAY DIFFRACTION88chain 'P' and (resid 32 through 55 )P32 - 55
89X-RAY DIFFRACTION89chain 'P' and (resid 56 through 83 )P56 - 83
90X-RAY DIFFRACTION90chain 'P' and (resid 84 through 90 )P84 - 90
91X-RAY DIFFRACTION91chain 'P' and (resid 91 through 103 )P91 - 103
92X-RAY DIFFRACTION92chain 'P' and (resid 104 through 124 )P104 - 124
93X-RAY DIFFRACTION93chain 'Q' and (resid 40 through 77 )Q40 - 77
94X-RAY DIFFRACTION94chain 'Q' and (resid 78 through 134 )Q78 - 134
95X-RAY DIFFRACTION95chain 'R' and (resid 22 through 30 )R22 - 30
96X-RAY DIFFRACTION96chain 'R' and (resid 31 through 48 )R31 - 48
97X-RAY DIFFRACTION97chain 'R' and (resid 49 through 82 )R49 - 82
98X-RAY DIFFRACTION98chain 'R' and (resid 83 through 92 )R83 - 92
99X-RAY DIFFRACTION99chain 'R' and (resid 93 through 101 )R93 - 101
100X-RAY DIFFRACTION100chain 'S' and (resid 12 through 26 )S12 - 26
101X-RAY DIFFRACTION101chain 'S' and (resid 27 through 35 )S27 - 35
102X-RAY DIFFRACTION102chain 'S' and (resid 36 through 46 )S36 - 46
103X-RAY DIFFRACTION103chain 'S' and (resid 47 through 72 )S47 - 72
104X-RAY DIFFRACTION104chain 'S' and (resid 73 through 79 )S73 - 79
105X-RAY DIFFRACTION105chain 'S' and (resid 80 through 96 )S80 - 96
106X-RAY DIFFRACTION106chain 'S' and (resid 97 through 106 )S97 - 106
107X-RAY DIFFRACTION107chain 'S' and (resid 107 through 111 )S107 - 111
108X-RAY DIFFRACTION108chain 'S' and (resid 112 through 118 )S112 - 118
109X-RAY DIFFRACTION109chain 'T' and (resid 32 through 37 )T32 - 37
110X-RAY DIFFRACTION110chain 'T' and (resid 38 through 48 )T38 - 48
111X-RAY DIFFRACTION111chain 'T' and (resid 49 through 55 )T49 - 55
112X-RAY DIFFRACTION112chain 'T' and (resid 56 through 83 )T56 - 83
113X-RAY DIFFRACTION113chain 'T' and (resid 84 through 90 )T84 - 90
114X-RAY DIFFRACTION114chain 'T' and (resid 91 through 104 )T91 - 104
115X-RAY DIFFRACTION115chain 'T' and (resid 105 through 124 )T105 - 124
116X-RAY DIFFRACTION116chain 'U' and (resid 2 through 21 )U2 - 21
117X-RAY DIFFRACTION117chain 'U' and (resid 22 through 71 )U22 - 71
118X-RAY DIFFRACTION118chain 'U' and (resid 72 through 111 )U72 - 111
119X-RAY DIFFRACTION119chain 'U' and (resid 112 through 147 )U112 - 147
120X-RAY DIFFRACTION120chain 'V' and (resid 1 through 30 )V1 - 30
121X-RAY DIFFRACTION121chain 'V' and (resid 31 through 50 )V31 - 50
122X-RAY DIFFRACTION122chain 'V' and (resid 51 through 80 )V51 - 80
123X-RAY DIFFRACTION123chain 'V' and (resid 81 through 110 )V81 - 110
124X-RAY DIFFRACTION124chain 'V' and (resid 111 through 130 )V111 - 130
125X-RAY DIFFRACTION125chain 'V' and (resid 131 through 147 )V131 - 147
126X-RAY DIFFRACTION126chain 'W' and (resid 2 through 30 )W2 - 30
127X-RAY DIFFRACTION127chain 'W' and (resid 31 through 47 )W31 - 47
128X-RAY DIFFRACTION128chain 'W' and (resid 48 through 65 )W48 - 65
129X-RAY DIFFRACTION129chain 'W' and (resid 66 through 76 )W66 - 76
130X-RAY DIFFRACTION130chain 'W' and (resid 77 through 89 )W77 - 89
131X-RAY DIFFRACTION131chain 'W' and (resid 90 through 116 )W90 - 116
132X-RAY DIFFRACTION132chain 'W' and (resid 117 through 137 )W117 - 137
133X-RAY DIFFRACTION133chain 'W' and (resid 138 through 149 )W138 - 149
134X-RAY DIFFRACTION134chain 'W' and (resid 150 through 161 )W150 - 161
135X-RAY DIFFRACTION135chain 'W' and (resid 162 through 176 )W162 - 176
136X-RAY DIFFRACTION136chain 'W' and (resid 177 through 188 )W177 - 188
137X-RAY DIFFRACTION137chain 'W' and (resid 189 through 200 )W189 - 200
138X-RAY DIFFRACTION138chain 'W' and (resid 201 through 212 )W201 - 212
139X-RAY DIFFRACTION139chain 'X' and (resid 2 through 16 )X2 - 16
140X-RAY DIFFRACTION140chain 'X' and (resid 17 through 37 )X17 - 37
141X-RAY DIFFRACTION141chain 'X' and (resid 38 through 42 )X38 - 42
142X-RAY DIFFRACTION142chain 'X' and (resid 45 through 49 )X45 - 49
143X-RAY DIFFRACTION143chain 'X' and (resid 50 through 68 )X50 - 68
144X-RAY DIFFRACTION144chain 'X' and (resid 69 through 89 )X69 - 89
145X-RAY DIFFRACTION145chain 'X' and (resid 90 through 145 )X90 - 145
146X-RAY DIFFRACTION146chain 'X' and (resid 146 through 189 )X146 - 189
147X-RAY DIFFRACTION147chain 'X' and (resid 190 through 200 )X190 - 200
148X-RAY DIFFRACTION148chain 'X' and (resid 201 through 211 )X201 - 211

+
万見について

-
お知らせ

-
2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

-
2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

+
2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

+
2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

+
2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

-
万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

他の情報も見る