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- PDB-6om3: Crystal structure of the Orc1 BAH domain in complex with a nucleo... -

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Basic information

Entry
Database: PDB / ID: 6om3
TitleCrystal structure of the Orc1 BAH domain in complex with a nucleosome core particle
Components
  • DNA (146-MER)
  • DNA (147-MER)
  • Histone H2A
  • Histone H2B 1.1
  • Histone H3.2
  • Histone H4
  • Origin recognition complex subunit 1
KeywordsStructural Protein/DNA / Chromatin Modifier / Structural Protein / Structural Protein-DNA complex
Function / homology
Function and homology information


CDC6 association with the ORC:origin complex / maintenance of rDNA / Assembly of the ORC complex at the origin of replication / nuclear origin of replication recognition complex / pre-replicative complex assembly involved in nuclear cell cycle DNA replication / Activation of the pre-replicative complex / nuclear pre-replicative complex / nucleosome organization / DNA replication preinitiation complex / Activation of ATR in response to replication stress ...CDC6 association with the ORC:origin complex / maintenance of rDNA / Assembly of the ORC complex at the origin of replication / nuclear origin of replication recognition complex / pre-replicative complex assembly involved in nuclear cell cycle DNA replication / Activation of the pre-replicative complex / nuclear pre-replicative complex / nucleosome organization / DNA replication preinitiation complex / Activation of ATR in response to replication stress / mitotic DNA replication checkpoint signaling / silent mating-type cassette heterochromatin formation / Orc1 removal from chromatin / DNA replication origin binding / DNA replication initiation / nucleosome binding / structural constituent of chromatin / nucleosome / heterochromatin formation / nucleosome assembly / protein heterodimerization activity / chromatin binding / ATP hydrolysis activity / DNA binding / nucleoplasm / ATP binding / metal ion binding / nucleus
Similarity search - Function
Bromo adjacent homology (BAH) domain / : / Origin recognition complex subunit 1 C-terminal winged HTH domain / AAA lid domain / AAA lid domain / : / Bromo adjacent homology domain / BAH domain / Bromo adjacent homology (BAH) domain / Bromo adjacent homology (BAH) domain superfamily ...Bromo adjacent homology (BAH) domain / : / Origin recognition complex subunit 1 C-terminal winged HTH domain / AAA lid domain / AAA lid domain / : / Bromo adjacent homology domain / BAH domain / Bromo adjacent homology (BAH) domain / Bromo adjacent homology (BAH) domain superfamily / BAH domain profile. / Histone, subunit A / Histone, subunit A / : / Histone H2B signature. / Histone H2A conserved site / Histone H2A signature. / Histone H2B / Histone H2B / Histone H2A, C-terminal domain / C-terminus of histone H2A / Histone 2A / Histone H2A / TATA box binding protein associated factor / TATA box binding protein associated factor (TAF), histone-like fold domain / Histone H4, conserved site / Histone H4 signature. / Histone H4 / Histone H4 / CENP-T/Histone H4, histone fold / Centromere kinetochore component CENP-T histone fold / ATPase family associated with various cellular activities (AAA) / SH3 type barrels. / ATPase, AAA-type, core / Histone H3 signature 1. / Histone H3 signature 2. / Histone H3 / Histone H3/CENP-A / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 domain / Histone-fold / Roll / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / Mainly Beta / Mainly Alpha
Similarity search - Domain/homology
DNA / DNA (> 10) / DNA (> 100) / Histone H2B 1.1 / Histone H2A type 1 / Origin recognition complex subunit 1 / Histone H4 / Histone H3.2 / Histone H2A
Similarity search - Component
Biological speciesXenopus laevis (African clawed frog)
Saccharomyces cerevisiae (brewer's yeast)
synthetic construct (others)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.3 Å
AuthorsDe Ioannes, P.E. / Wang, M. / Armache, K.-J.
Funding support United States, 2items
OrganizationGrant numberCountry
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)R01GM115882 United States
Other privateThe David and Lucile Packard Foundation United States
CitationJournal: Nat Commun / Year: 2019
Title: Structure and function of the Orc1 BAH-nucleosome complex.
Authors: De Ioannes, P. / Leon, V.A. / Kuang, Z. / Wang, M. / Boeke, J.D. / Hochwagen, A. / Armache, K.J.
History
DepositionApr 18, 2019Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jul 10, 2019Provider: repository / Type: Initial release
Revision 1.1Jul 17, 2019Group: Data collection / Database references / Category: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name
Revision 1.2Jan 1, 2020Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization
Revision 1.3Oct 11, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 1.4Oct 23, 2024Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Histone H3.2
B: Histone H4
C: Histone H2A
D: Histone H2B 1.1
E: Histone H3.2
F: Histone H4
G: Histone H2A
H: Histone H2B 1.1
I: DNA (146-MER)
J: DNA (147-MER)
K: Origin recognition complex subunit 1
L: Origin recognition complex subunit 1
M: Histone H3.2
N: Histone H4
O: Histone H2A
P: Histone H2B 1.1
Q: Histone H3.2
R: Histone H4
S: Histone H2A
T: Histone H2B 1.1
U: DNA (146-MER)
V: DNA (147-MER)
W: Origin recognition complex subunit 1
X: Origin recognition complex subunit 1


Theoretical massNumber of molelcules
Total (without water)504,28624
Polymers504,28624
Non-polymers00
Water00
1
A: Histone H3.2
B: Histone H4
C: Histone H2A
D: Histone H2B 1.1
E: Histone H3.2
F: Histone H4
G: Histone H2A
H: Histone H2B 1.1
I: DNA (146-MER)
J: DNA (147-MER)
K: Origin recognition complex subunit 1
L: Origin recognition complex subunit 1


Theoretical massNumber of molelcules
Total (without water)252,14312
Polymers252,14312
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
M: Histone H3.2
N: Histone H4
O: Histone H2A
P: Histone H2B 1.1
Q: Histone H3.2
R: Histone H4
S: Histone H2A
T: Histone H2B 1.1
U: DNA (146-MER)
V: DNA (147-MER)
W: Origin recognition complex subunit 1
X: Origin recognition complex subunit 1


Theoretical massNumber of molelcules
Total (without water)252,14312
Polymers252,14312
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)100.254, 166.428, 168.277
Angle α, β, γ (deg.)90.000, 90.280, 90.000
Int Tables number4
Space group name H-MP1211

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Components

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Protein , 5 types, 20 molecules AEMQBFNRCGOSDHPTKLWX

#1: Protein
Histone H3.2


Mass: 15303.930 Da / Num. of mol.: 4 / Mutation: G102A
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Xenopus laevis (African clawed frog) / Production host: Escherichia coli (E. coli) / References: UniProt: P84233
#2: Protein
Histone H4


Mass: 11394.426 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Xenopus laevis (African clawed frog) / Production host: Escherichia coli (E. coli) / References: UniProt: P62799
#3: Protein
Histone H2A


Mass: 14109.436 Da / Num. of mol.: 4 / Mutation: G99R, S123A
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Xenopus laevis (African clawed frog) / Gene: hist1h2aj, LOC494591, XELAEV_18003602mg / Variant: ATCC 204508 / S288c / Production host: Escherichia coli (E. coli) / References: UniProt: Q6AZJ8, UniProt: P06897*PLUS
#4: Protein
Histone H2B 1.1 / H2B1.1


Mass: 13979.291 Da / Num. of mol.: 4 / Mutation: S32T
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Xenopus laevis (African clawed frog) / Production host: Escherichia coli (E. coli) / References: UniProt: P02281
#7: Protein
Origin recognition complex subunit 1 / Origin recognition complex 120 kDa subunit


Mass: 26067.488 Da / Num. of mol.: 4 / Mutation: L79I
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Strain: ATCC 204508 / S288c / Gene: ORC1, YML065W / Variant: ATCC 204508 / S288c / Production host: Spodoptera frugiperda (fall armyworm) / References: UniProt: P54784

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DNA chain , 2 types, 4 molecules IUJV

#5: DNA chain DNA (146-MER)


Mass: 44824.570 Da / Num. of mol.: 2 / Source method: obtained synthetically / Source: (synth.) synthetic construct (others)
#6: DNA chain DNA (147-MER)


Mass: 45609.055 Da / Num. of mol.: 2 / Source method: obtained synthetically / Source: (synth.) synthetic construct (others)

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Details

Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.8 Å3/Da / Density % sol: 60.48 %
Crystal growTemperature: 277.15 K / Method: vapor diffusion, sitting drop / pH: 6
Details: 6 mM Na-Cacodylate pH 6.0, 0.4 mM Spermine-HCl, 2 mM MgCl2 and 1.75% v/v PEG 400

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Data collection

DiffractionMean temperature: 110 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 24-ID-C / Wavelength: 0.9791 Å
DetectorType: DECTRIS PILATUS 6M-F / Detector: PIXEL / Date: Oct 29, 2017
Details: Cryogenically-cooled single crystal Si(220) side bounce monochromator
RadiationMonochromator: Cryo-Cooled double crystal / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9791 Å / Relative weight: 1
ReflectionResolution: 3.3→50 Å / Num. obs: 81623 / % possible obs: 97.9 % / Redundancy: 3 % / Biso Wilson estimate: 112.42 Å2 / Rmerge(I) obs: 0.117 / Rpim(I) all: 0.079 / Rrim(I) all: 0.142 / Χ2: 1.264 / Net I/σ(I): 5.2 / Num. measured all: 248201
Reflection shell

Diffraction-ID: 1

Resolution (Å)Redundancy (%)Rmerge(I) obsNum. unique obsCC1/2Rpim(I) allRrim(I) allΧ2% possible all
3.3-3.3630.83740730.4850.5661.0140.51498.1
3.36-3.4230.72740470.5460.490.8810.53798.3
3.42-3.4830.62241160.5990.420.7540.61498.2
3.48-3.5530.53940180.6650.3620.6520.66598
3.55-3.6330.4540540.7240.3070.5470.75497.6
3.63-3.722.90.41540740.7420.2850.5060.78497.3
3.72-3.812.70.35739670.7620.2540.440.97595.9
3.81-3.913.10.30841280.8350.2080.3730.99999
3.91-4.033.20.25441250.890.170.3071.10898.8
4.03-4.163.20.22541150.9010.1510.2731.19399.1
4.16-4.313.20.18941030.9110.1280.2291.33598.8
4.31-4.483.10.16440930.9370.1110.1981.39798.5
4.48-4.683.10.14940560.9450.1020.1811.46397.5
4.68-4.932.90.13340360.9580.0930.1631.596.5
4.93-5.2430.12540400.960.0860.1521.62596.9
5.24-5.643.20.11441030.9610.0770.1381.48998.3
5.64-6.213.20.10241170.9680.0690.1241.48598.5
6.21-7.130.08740960.9770.0610.1071.5597.5
7.1-8.9430.07840990.9790.0530.0942.08197.5
8.94-5030.08141630.9860.0540.0982.98897.3

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Processing

Software
NameVersionClassification
PHENIX12-2829refinement
HKL-2000HKL2000_v718-Macdata scaling
PDB_EXTRACT3.24data extraction
HKL-2000HKL2000_v718-Macdata reduction
PHASER2.8.0phasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 3tu4, 1M4Z, 3LZ1

3tu4

1m4z

3lz1


Resolution: 3.3→49.054 Å / SU ML: 0.5 / Cross valid method: THROUGHOUT / σ(F): 1.36 / Phase error: 27.11
RfactorNum. reflection% reflection
Rfree0.2497 8111 9.99 %
Rwork0.213 --
obs0.2167 81181 97.81 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å
Displacement parametersBiso max: 381.68 Å2 / Biso mean: 133.4376 Å2 / Biso min: 44.93 Å2
Refinement stepCycle: final / Resolution: 3.3→49.054 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms16894 12012 0 0 28906
Num. residues----2782
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00330592
X-RAY DIFFRACTIONf_angle_d0.55543919
X-RAY DIFFRACTIONf_chiral_restr0.0365058
X-RAY DIFFRACTIONf_plane_restr0.0043552
X-RAY DIFFRACTIONf_dihedral_angle_d22.34516292
LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Rfactor Rfree error: 0 / Total num. of bins used: 30

Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkNum. reflection all% reflection obs (%)
3.3-3.33750.33412730.32642440271397
3.3375-3.37670.3552670.32182391265898
3.3767-3.41790.34612690.31492434270398
3.4179-3.46120.34922650.30442427269298
3.4612-3.50670.31942750.29362455273098
3.5067-3.55470.3242720.29172405267798
3.5547-3.60550.30852560.27642449270598
3.6055-3.65930.32532630.29562412267598
3.6593-3.71650.32572750.2842428270397
3.7165-3.77740.29672620.27262386264896
3.7774-3.84250.31742620.26922422268497
3.8425-3.91230.29532770.26562441271899
3.9123-3.98750.27512720.24942448272099
3.9875-4.06890.26692680.24492460272899
4.0689-4.15730.27582840.23822471275599
4.1573-4.2540.2742620.2312433269599
4.254-4.36030.26942810.22872496277799
4.3603-4.47810.27272690.22452399266898
4.4781-4.60980.2532690.21892430269998
4.6098-4.75850.24812590.2112464272397
4.7585-4.92840.24692810.20632354263596
4.9284-5.12550.24922670.20262383265096
5.1255-5.35850.23462800.20952462274299
5.3585-5.64060.2572660.21312443270998
5.6406-5.99350.25482720.21162460273299
5.9935-6.45530.26472800.21792450273098
6.4553-7.10320.26422680.21532439270797
7.1032-8.1270.21772750.17252434270997
8.127-10.22390.20062760.15712465274198
10.2239-49.05980.16892660.152489275597
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
19.2358-1.12485.34851.2608-0.36148.57360.35090.752-1.0171-0.446-0.6327-0.94380.55261.059-0.32051.9999-0.4916-0.4157-0.2196-0.00031.2779-84.667910.6122-114.2865
22.1444-0.3866-1.18891.87221.30481.3401-0.8106-0.1020.6176-0.6016-0.50560.19061.5226-0.8209-0.38521.0473-0.2601-0.1971.1580.4660.8403-71.387513.1414-109.7763
35.16150.9164-4.20556.5419-2.32053.83290.0551-0.6078-0.4769-1.46851.33970.31351.9535-0.4061-0.5121.3141-0.1553-0.18450.9460.02850.7246-59.701415.9756-115.8301
43.49980.4561-0.14072.7975-0.16971.54010.25580.7971-0.1389-2.55980.34760.3545-0.06651.3477-0.31391.0994-0.2261-0.08341.0563-0.05840.8855-52.531328.7116-126.0232
56.3698-4.03650.74893.62390.09310.47160.22143.3581-0.4159-2.3759-1.8146-0.6409-0.61870.0499-0.63761.325-0.06520.13480.7321-0.12660.6183-42.517931.2489-126.6821
68.437-1.4659-5.86924.65970.48354.7998-0.807-1.0538-1.67280.09830.28850.86771.13960.2253-0.24360.6975-0.1463-0.17331.1744-0.20460.7846-59.86825.7808-109.4086
71.29930.6479-0.80314.76852.03335.19311.8726-0.20492.78291.04760.04050.4399-0.057-0.57180.35840.4116-0.53580.06661.54190.1511.1099-77.131130.1449-104.7323
84.0928-1.00490.41932.55532.45014.39470.7987-0.12670.9424-1.1922-0.2727-1.9252-1.69951.33470.31550.9349-0.33670.2230.7128-0.32971.6025-64.917937.5182-105.4332
95.21072.7971-6.16991.5254-2.99598.3314-0.03281.0153-0.2415-1.2041-0.1660.22871.13780.0903-0.29841.4598-0.2145-0.33261.15240.35430.8736-56.766630.0568-131.2625
101.95880.2113-1.17883.0539-0.30525.7813-0.59530.9369-0.56070.47111.03160.8470.8155-1.746-0.38960.6788-0.0524-0.21360.81990.23781.0246-70.359122.9497-113.3389
112.60752.9703-0.42733.5109-0.47083.30310.3582.03811.3665-0.54040.3581-0.0873-0.19550.0329-0.57590.78760.03550.05760.84450.0530.7394-49.366233.3532-118.138
126.33050.1119-1.18317.624.10445.7336-0.5449-1.43650.0951-0.14490.3423-0.7874-1.69151.878-0.161.1471-0.2403-0.0420.80.06790.5713-42.640129.6539-110.7701
132.08621.33870.99023.45933.37523.36241.8739-0.6054-0.6039-0.488-1.93170.67271.1357-0.76040.30811.30980.01110.07860.8384-0.00140.7739-46.075623.7504-107.3812
142.8997-1.9153.41356.1857-1.20334.24280.0914-0.211-1.87261.15780.2497-0.46640.3245-1.0328-0.34971.6352-0.52780.06990.5047-0.14520.7411-25.005859.3613-105.6108
155.31475.189-2.68475.1732-2.59051.5161-0.3628-1.778-0.00372.3171-0.9516-3.092-0.64350.9732-0.3850.8878-0.083-0.12731.1002-0.27790.9376-24.668248.7902-99.7666
164.2502-1.8464-0.25623.29752.16986.15951.2846-0.33410.8054-0.8128-0.8824-0.3144-1.3891.0728-0.43420.9217-0.33080.27320.58450.04321.0819-36.514753.4519-104.4714
175.4736-0.286-0.57821.4980.83230.69070.281-0.3890.6033-0.3508-0.05990.1822-0.6817-0.2065-0.04071.0063-0.06540.17420.905-0.2980.9567-57.148154.8166-97.8616
182.9756-0.3526-0.0562.8090.04833.7739-0.4721-0.36130.87010.7349-0.0391-0.9068-1.73380.52590.26581.0405-0.17780.16371.3507-0.03341.3541-32.910860.6342-94.9913
192.1956-0.6055-0.43765.35190.47123.61090.2655-0.28910.0365-0.3150.14620.6871-0.8150.7562-0.26750.8565-0.1782-0.00180.5474-0.08350.7563-36.473447.5094-101.3492
205.9927-0.1609-0.56731.64532.20552.63670.31141.18290.5539-0.4505-0.6101-0.1963-0.50890.12270.30070.8166-0.16090.12080.79920.05590.7818-34.740750.3646-113.9451
211.9795-1.4210.00811.17930.23171.61990.82550.45471.95870.1271-0.24960.8295-1.21570.0294-0.18111.41040.24230.42070.4180.11931.7627-70.101856.8031-85.7554
225.39090.54460.77732.31460.6411.93370.2523-1.9847-0.10921.0195-0.5841-0.204-0.1305-0.7772-0.16231.4273-0.05940.0561.0975-0.11330.5682-48.876640.4968-71.445
236.2924-0.99044.78674.6662-0.71262.4470.34210.72641.1538-0.1341-0.4020.0493-0.77220.4924-0.13910.7268-0.02230.33021.0949-0.18320.8137-63.413343.6219-89.3398
247.8337-0.5313-1.17454.09770.28256.1520.6639-1.1064-0.7150.8903-0.20990.49090.38380.9307-0.41230.83950.00930.0280.8016-0.09760.8002-64.976732.8836-92.4307
251.22230.14091.26290.5533-0.36051.74550.22830.0953-0.5921-0.0974-0.4227-0.0642-0.8583-0.27460.31252.07821.9297-0.6202-1.21450.47470.66-53.726838.6267-62.0477
266.3492-1.80990.57545.49292.87972.05520.2043-0.48830.82520.5599-0.20070.0937-0.6123-2.0837-0.081.13260.10.3171.0658-0.36751.0304-65.088246.8938-79.3705
278.0368-0.67022.21370.6851-1.6682.72550.7675-0.482-2.56850.09220.00981.03220.34990.0346-0.60870.827-0.16420.14030.6209-0.12521.1326-57.533637.8989-81.9681
284.2466-2.30065.31654.0975-1.18497.49710.45-1.19551.0507-0.2744-0.2597-1.02531.0549-0.175-0.58270.743-0.28020.15170.9359-0.20581.0516-40.074140.0916-82.3479
293.0681-1.8128-3.47184.6849-1.05846.64041.2014-0.62160.27650.6104-0.30270.0679-0.55330.0041-0.97751.1702-0.19540.06970.7038-0.03550.837-46.595146.1703-90.4291
300.14050.8194-0.23884.8117-1.11751.7847-0.45880.2172-0.2822-0.31430.1176-1.3050.05660.3162-1.26011.9542-0.32590.06190.32-1.40022.6076-14.68097.5644-92.6059
313.7728-1.7218-2.66394.36592.05672.08860.1957-0.67760.91763.21570.9705-1.6208-1.0821-0.8987-1.07111.65350.4937-0.15621.11750.39581.4529-26.496810.6585-91.4306
324.1745-2.3970.58173.2131-2.40982.4846-0.0858-1.75310.65-1.42260.1875-2.02240.65770.14590.31480.8054-0.0686-0.07121.1091-0.22411.0692-24.688220.9384-97.4828
333.0222-5.503-2.09562.0282.7346.2010.8701-2.3332-1.7637-0.50761.0825-0.6645-0.9653-0.3407-1.13190.7744-0.2609-0.28720.87420.1340.9798-24.224628.8618-94.0207
343.0548-1.986-0.20053.47571.2074.11570.4292-1.0704-1.72990.2549-0.1852-0.96911.9233-0.3084-0.3241.24160.0771-0.16770.54460.2120.7717-41.404211.8988-92.9205
355.28232.01811.81733.4457-3.00485.78320.405-0.6955-0.6056-1.9248-1.48971.29081.8311-0.96030.48941.4133-0.0829-0.48041.029-0.0520.7329-50.54651.8696-104.9632
363.65480.60231.19024.8949-0.07480.56730.7375-0.73820.56280.8395-0.5547-0.46091.2177-0.2708-0.24061.0719-0.1975-0.09080.7029-0.08030.7131-52.728315.7811-96.678
377.71381.36940.34483.1366-1.42513.9012-0.45291.75370.13831.02641.08151.21361.14850.2224-0.13030.9016-0.0568-0.17860.61930.00120.8258-56.055119.0222-102.8774
380.44560.6855-0.18762.14851.25332.03720.854-0.0796-0.2315-1.3455-0.61650.1093-0.2011-0.7805-0.48781.2321-0.0248-0.15090.9850.10541.4405-77.435318.3935-99.2787
393.5408-0.6413-3.8095.64613.03711.99450.46471.55321.7467-2.0767-0.414-0.0761-1.22112.48911.12710.56670.4191-1.18741.70110.69920.3458-28.555815.4606-108.8644
402.5880.4974-3.50897.13060.07111.97780.9825-1.1617-0.790.60890.8806-1.35291.0312-1.3643-1.28981.27790.0977-0.25190.72210.19191.0246-36.20075.3517-98.6799
414.8034-0.3029-2.25670.087-0.05234.9332-0.1923-0.3525-1.7905-1.3073-1.49890.18161.5583-0.35880.05211.55230.0492-0.12561.01060.16280.8098-43.67270.9997-100.8579
424.58131.45491.07253.5135-0.90924.27070.05230.24490.4499-1.0392-0.4230.0365-0.57960.29340.29850.48590.05010.0210.69050.00240.7716-37.477324.2594-97.5352
434.81960.3674-0.97991.97160.95771.91280.5245-0.84670.22470.9959-1.8854-0.88870.60960.823-0.21481.1827-0.0156-0.28241.261-0.16891.105-25.943534.2318-85.7313
442.12582.77090.97868.99420.4367.77151.2518-0.3641.01320.7724-0.64-0.080.4502-0.4209-0.24760.7239-0.12240.04830.7007-0.10120.7475-37.088426.0328-85.0509
451.57150.21390.94455.50620.53290.6160.9769-1.2829-0.40132.5102-0.8620.7926-0.190.2378-0.33360.88360.3181-0.29641.59290.38860.3815-33.481415.0624-82.6936
461.64610.51870.24991.9158-0.07362.1570.2923-0.4049-0.04030.1666-0.05210.20030.2972-0.0918-0.24091.0679-0.1065-0.02581.00550.12580.8555-55.280125.2329-95.918
474.47820.8633-0.33443.08730.38241.68820.5591-0.22250.56020.0585-0.0456-0.4768-0.2730.4733-0.41441.09740.0797-0.02430.90090.39720.4527-39.873850.2801-102.8555
48-0.18620.00060.14972.1109-0.00690.0425-0.30040.0498-0.08070.52450.11730.2929-0.71030.06870.14812.0202-0.0590.04751.3755-0.18631.3824-53.389170.3522-86.6124
493.68250.3551-0.70632.41770.97732.5749-0.22550.1179-0.1947-0.280.24530.2170.18650.1355-0.02691.04520.1337-0.10430.6830.35430.7714-57.003632.3182-109.8382
502.8117-0.1360.73232.03260.17070.8088-0.2411-0.40861.09540.84930.3472-0.9558-0.171.1274-0.33211.5732-0.3105-0.26181.6305-0.04351.1895-25.298438.9974-77.9075
512.65313.0291-1.19062.29540.35741.32-0.46550.5644-0.8328-0.68110.4094-0.42450.61960.01560.00861.84460.0426-0.23451.08620.15130.8551-57.0792-0.6537-112.3663
521.719-1.9568-0.31754.0615-0.46583.9981-1.365-0.2677-0.68571.09420.7083-0.05680.3005-0.79380.371.12240.007-0.06290.9135-0.02761.1823-36.833657.0198-128.8396
530.5117-1.00481.43812.9152-1.6354.1558-0.04480.1591-0.1082-0.8866-0.3648-0.3794-0.0532-0.52420.29260.9884-0.14860.05540.64420.02560.778-41.091755.373-131.4606
541.56661.64983.02664.21780.3643.88910.38680.45120.28670.3696-0.0560.0752-0.0481-0.1903-0.27050.7745-0.05350.09110.8330.0170.7911-43.11944.5597-139.4564
550.6378-1.02120.4581.8096-1.36875.9991-0.46812.2436-0.1379-0.0064-0.73750.6376-0.4416-0.64120.04471.1350.374-0.09851.18240.21490.9519-54.179254.5945-152.7541
565.7229-1.9425-0.29564.06810.98780.32090.9982-0.1372-0.54010.3123-1.59740.3182-0.91631.3604-0.04821.1829-0.1256-0.0121.35440.30640.7107-49.988751.0797-153.0595
573.65542.17952.61866.11144.60863.87510.4953-0.5362-0.496-0.3028-0.85970.4905-0.1876-1.76030.22591.0708-0.01990.11771.23110.18261.3042-57.364345.2608-137.2361
583.71441.5802-3.42147.443-1.53554.6594-0.06150.07560.34311.08261.18910.8581-0.0421.8991-0.03031.5940.2624-0.2481.3328-0.0710.6423-31.801216.1846-66.9405
591.9629-0.64620.02595.0453-4.54338.84910.65590.0380.6179-1.90040.30020.4329-0.60050.0053-0.2330.9592-0.0821-0.19210.80470.11211.445-45.14777.2231-78.1246
602.0602-0.6132-1.70047.06961.35371.91350.0144-0.91440.184-1.10670.46260.1777-0.34850.95650.69841.76850.108-0.11061.5520.0150.986-40.317814.2647-59.9968
613.617-3.0027-4.37954.87070.73339.07280.2956-0.61730.20060.1893-0.57640.1213-1.55480.65030.21091.5016-0.1467-0.2111.29560.07850.7949-41.041725.3551-62.9239
62-0.0702-0.4079-0.16562.78941.3931.5907-0.7294-0.001-0.5899-0.45870.80210.99530.3408-0.74650.01042.0461-0.25320.22741.38910.11240.8111-55.189635.1857-44.7537
633.81230.198-2.60221.20320.29581.97280.61281.90.47060.793-0.02220.2486-0.1858-1.45981.35943.1287-0.64130.06931.2424-0.14710.0873-54.164537.6912-35.6091
643.00010.4207-2.8797-0.0307-0.43422.5739-1.05482.30540.65371.3547-0.06280.19922.1163-2.58920.18992.0016-0.15110.18151.36550.16931.1304-48.765727.3791-52.2828
652.6104-2.1402-0.5432.2631-0.83473.8247-0.0814-0.71011.17752.8556-0.40680.42680.65761.81650.12772.9022-0.38610.07530.9374-0.35130.7341-46.213717.433-50.1861
663.987-3.20291.07458.7952-3.22996.27240.54642.2224-0.05672.964-0.56282.57910.14780.57440.2132.0437-0.02460.08361.27450.22641.1032-50.509319.0354-44.6479
676.3189-1.0731-0.66631.27781.43936.2894-0.94220.5818-0.5590.8941-0.9322-0.0426-0.2977-1.4933-0.26881.9464-0.22260.481.0941-0.00881.6644-59.078531.1625-53.1792
688.3392-4.13852.0476.0106-0.81240.4903-0.29840.4859-1.2076-1.08911.0823-0.6310.94680.5115-0.22392.5135-0.63080.13431.7366-0.30981.7087-56.221716.1152-60.0761
690.8972-1.2251-0.01311.65160.16240.1403-0.19570.0731-0.4848-0.8256-0.74540.0906-0.6683-0.3558-0.3661.5366-0.2826-0.16531.1634-0.21381.1377-58.641225.9315-65.7001
705.10622.31921.08043.5577-2.72244.70271.09880.25521.3765-0.20120.80040.78090.80850.0128-2.19010.7520.4028-0.08871.3316-0.07181.413332.3621.85828.6277
714.4862-3.3681.96763.5188-0.153.076-0.79290.1082-2.03360.3871-0.4667-0.74512.48560.7180.59150.88070.00630.0460.77110.240.859119.029424.47871.2592
725.07650.1307-3.11622.78981.23832.4362-0.2853-0.6893-0.19380.64960.4547-0.0978-0.2020.8907-0.03650.61640.0756-0.10831.30130.18660.7478-1.471140.15110.3296
738.7343-1.3998-2.92042.8017-0.82172.9066-0.15450.5092-1.6258-0.0958-0.0982-0.36930.234-0.28880.37640.54370.07260.03740.86480.08940.91338.712437.6916-2.2012
743.5649-0.06170.39464.26371.28464.57460.49110.70762.21011.10060.5744-0.2748-0.75580.60780.47940.6130.29190.18181.09520.32341.041126.969540.3739-4.4904
755.6687-2.32481.88272.8699-1.92038.47940.10560.15321.54840.12780.38920.3614-1.0782-0.26560.55360.80080.1075-0.20570.58010.2910.872215.434348.249-6.678
762.1891-2.9754-2.95744.36084.3145.3023-1.74140.30690.28391.9003-0.1187-1.82240.37822.44521.24951.52580.17310.07692.21090.30281.4693-0.234446.951922.1661
771.94420.47960.79662.79170.95073.4485-0.1404-0.3601-0.73770.3763-0.2240.29060.79030.81980.24110.54980.0451-0.0981.21040.17870.71613.060236.07737.8171
784.29850.2752-1.26372.0649-0.78332.0611-0.2209-0.18130.71070.34460.295-0.2423-0.3965-0.09110.00640.49910.0328-0.07080.74010.03280.59772.381545.12863.6541
797.6023-3.0926-1.29239.82192.2047.71140.16481.5294-1.0342-0.3835-0.5411.6028-1.0891-0.70370.48690.61710.0083-0.07590.6652-0.08820.7641-6.662840.1957-4.8614
806.1002-5.5355-5.45954.98644.90884.9066-0.64091.34150.65610.1140.53250.0866-1.9234-0.5163-0.28841.18620.19810.03341.11930.10681.3678-23.583274.1881-15.0338
811.0603-1.73380.27173.7492-1.09860.5514-0.4557-0.131-0.4339-1.17452.51122.2413-0.4329-1.4702-0.69980.719-0.1693-0.26881.07670.13570.7716-22.288262.1974-19.2886
825.5105-0.4418-3.73738.1160.62074.68370.1723-0.26840.74430.50371.7624-0.67091.3556-0.1606-1.38060.5107-0.0214-0.16010.6895-0.22010.9194-24.469154.3078-15.3911
833.75241.0279-4.23662.3237-3.20856.42720.8748-1.08141.51650.618-0.89081.3065-0.94891.17510.08270.65130.04990.03010.6230.09641.0423-5.619271.0006-12.8143
841.99486.46270.54225.98950.7870.1289-1.16430.4104-3.34250.09441.4264-1.8213-1.7253-0.14130.09861.0787-0.1883-0.15951.25830.34191.00415.98678.5662-24.0793
853.57731.4-1.40866.6001-2.14191.56550.02140.9089-1.3541.33230.29510.83560.1164-0.1236-0.23910.47170.2130.1460.85030.34290.82646.997767.8871-18.2471
866.47881.18861.92875.0649-3.89494.040.2095-0.16340.1272-0.48150.0893-0.25580.31290.8971-0.01480.42870.0411-0.02010.79390.05030.70147.079161.6341-16.1461
879.61671.23995.38674.124-1.80564.658-1.75430.111.54962.3775-0.89041.7209-0.1608-0.7180.83541.0658-0.23680.36261.08650.06050.8430.338361.3852-12.9519
884.2788-2.6684-0.65733.2232-0.45746.7755-0.02760.95170.2977-0.71850.0415-0.2142-1.3479-0.19740.02690.5810.01150.1520.8560.080.7287-9.333574.892-22.913
893.64845.7487-2.33437.5582-3.14793.9008-0.42580.5853-0.7193-2.0080.3611-0.10660.7284-0.5680.19120.60960.1219-0.03580.60650.02990.6472-9.940158.2128-17.1894
907.97490.19972.06763.1497-1.41978.27320.4237-0.57150.17341.3135-2.03060.60490.21530.61221.82010.8865-0.137-0.07460.7190.04520.8997-24.078149.9386-6.4233
915.0467-2.6693-2.15473.2189-1.34234.15930.42220.2014-0.77130.286-0.36780.52720.1376-0.0521-0.08810.5361-0.02120.03240.80350.01280.8288-12.608757.626-4.4931
924.6075-0.4838-0.35194.4307-0.00932.3272-0.7397-1.1714-1.01330.43151.3607-0.0809-1.1547-0.5988-0.14840.80880.3334-0.13291.28140.07790.7857-15.33768.802-3.4954
938.4381.7426-0.32991.62661.16184.3016-0.83790.7771-0.1785-1.06650.5471-0.5161-0.38620.55070.63790.88950.06190.13410.72160.10230.833919.339959.6376-32.132
949.35531.77093.80383.52510.133.60010.4415-0.87430.1624-0.362-0.4632-0.25730.5819-0.36410.00020.5615-0.04140.19740.5712-0.04870.616114.034149.5325-25.3265
956.6716-1.55436.26470.3457-1.44275.87160.58083.3005-2.4821-2.25361.3291-1.1524-0.02791.6515-0.26881.04490.11690.37211.7625-0.22161.171717.002547.9477-41.4579
965.11381.23234.55130.63630.61915.7088-0.00171.23730.5895-0.6687-0.0695-0.9169-1.03551.66180.39040.70590.11020.15040.87670.18690.830624.459856.4321-27.2024
977.39611.81671.24483.51451.18380.32620.33070.4127-1.5577-0.4742-0.2316-0.45450.67950.20940.2090.88320.09030.07050.66370.07180.59834.516346.0408-34.1896
987.8676-0.6674-3.37833.3264-3.71767.51780.3216-2.41431.7732-0.0481.08610.89760.49890.0398-1.33950.43470.0815-0.07940.9595-0.0010.5257-4.032351.5077-28.9329
992.64062.0464-3.62012.1171-1.88066.32271.1026-0.20590.3169-2.501-0.9737-0.80560.52071.83330.53741.09990.08490.09921.0870.00140.58740.02155.6411-25.1038
1002.24570.4054-3.5230.843-1.38156.4316-1.9009-0.1033-0.69030.6183-1.2228-0.41980.33471.06760.14691.0762-0.3835-0.34080.79480.21091.6773-25.88922.8366-23.5894
1012.0842-0.0176-2.36327.314-0.87652.831-1.06040.269-0.4303-0.5848-0.16021.17310.4642-1.251-0.52630.5583-0.0011-0.17781.00190.07341.1323-24.465834.3828-18.629
1028.2694-1.2939-0.04748.20621.00345.22791.2980.23560.7263-0.0629-0.74090.52240.02021.4193-0.30521.1330.15860.14210.63580.15561.1506-24.03342.337-23.2594
1031.91560.06061.35732.2835-0.81043.86530.5869-0.1404-0.8119-1.5373-0.1238-0.33591.375-0.0961-0.41210.6501-0.1822-0.00740.5215-0.06750.8269-8.090122.9988-19.9461
1042.2724-3.28291.58715.216-2.02631.2509-0.4213-1.9036-0.47210.82980.30750.61990.63691.63540.02460.99940.2450.07941.24850.3071.2905-1.292213.9608-5.4698
1054.8856-0.9699-0.00154.8046-0.43846.91140.0562-0.3766-0.2101-0.5147-0.2884-0.1212-0.93351.68480.38010.5811-0.04830.00030.60510.03170.78942.701126.9076-14.8323
1068.4017-2.18931.71666.5033-0.24242.2735-0.68420.5882-1.11461.79030.075-0.7717-1.20640.45810.42590.7460.0274-0.32160.835-0.08220.69040.61332.8424-8.395
1072.8104-0.05440.24680.36520.38040.4031-0.325-0.06090.2345-0.80960.0983-0.7942-0.01370.0474-0.177-0.66721.26050.4104-0.3831-0.51.817213.877226.7589-8.6084
1082.56683.26761.34818.44384.47032.477-0.7777-0.5778-0.20961.7717-0.93351.37920.45340.453-1.34971.2858-0.0780.28940.820.29680.746127.307727.8219-8.6638
1097.85286.8328-6.63237.2514-5.66725.59551.63231.01380.54940.415-0.41631.49850.30321.1666-0.48630.65240.0995-0.31831.504-0.00491.2999-22.629429.7222-6.7701
1107.4971-5.35341.14383.9804-1.60028.2657-0.32460.5402-1.03661.69351.25310.80621.3524-2.144-0.32830.794-0.11660.03990.54830.20061.2638-14.792817.9929-14.5995
1115.4235-0.7692-1.82240.5368-1.40727.01330.441.2069-1.404-0.055-0.4811.05610.8007-0.2216-0.73540.9150.36010.25281.10080.28582.3969-7.940913.5359-11.0057
1120.2506-1.0878-0.01123.438-2.53136.5019-0.3538-0.1437-0.554-0.42190.0289-0.0802-0.3019-0.83070.24320.5161-0.0491-0.20370.82490.01840.781-11.617536.6456-17.1235
1130.7297-0.13380.27522.1158-1.78351.4694-0.7746-1.70730.5168-1.2222-1.4479-0.933-0.8837-0.72721.09521.28280.2851-0.20070.80550.06150.7975-20.293746.2381-31.2083
1141.02311.6555-0.47315.48120.05046.3140.1441.9109-0.9513-1.9085-0.0372-0.1494-0.5081.1337-0.09030.8406-0.1002-0.20960.9296-0.16770.7437-9.754436.8975-29.7197
1156.18860.75063.06697.86781.92634.62330.26531.4655-1.3919-0.7941.6337-0.81861.38150.9067-1.47221.1809-0.2216-0.36671.1686-0.13070.8503-14.846525.9897-31.6392
116-0.0557-0.43870.25415.7144-0.82511.1248-0.77720.18720.32250.18330.3079-0.74630.1025-0.17770.18861.02530.0022-0.08821.12880.05441.657611.4959.61385.692
1173.25261.0849-0.47212.2281-0.94272.0107-0.18270.89110.1303-0.80510.18670.23340.1396-0.26180.0451.11510.08340.14790.7357-0.380.7937-5.276347.5828-34.3376
1182.0303-0.6357-0.62281.7827-1.05472.5236-0.0983-0.5053-0.2620.3370.01680.0477-0.06020.30990.02290.9024-0.0795-0.01060.9664-0.04850.94072.866236.785610.2905
1190.83520.3192.2163.5332-1.44663.5095-0.55831.09081.3939-0.65540.27320.0519-0.27410.2696-0.10891.04720.25250.13620.9686-0.06290.90321.100876.6338-28.3898
1202.34091.2420.63732.3246-0.85070.3292-0.36781.14421.4866-0.3583-0.0097-0.0721-0.28790.35590.23421.4701-0.02280.11051.56940.16231.24799.617380.1854-29.7862
1211.5352-0.5478-1.90583.2148-1.51161.62590.11560.5657-0.38430.310.49251.5233-0.1982-0.6632-0.35650.9231-0.18930.03451.5330.0541.3738-33.602750.5001-1.3573
1221.4274-1.87651.21441.7653-0.94633.4869-0.2975-0.99180.02440.28840.0266-0.5670.04360.66320.3110.952-0.0109-0.08111.40050.12041.231124.072335.80068.5176
1236.07041.12382.65311.88090.02472.1379-0.35541.54021.2483-1.1454-0.07690.2813-0.07560.41680.38791.6430.09420.06381.04840.19431.09674.198558.8429-45.8966
1244.2533-1.7671-1.70543.5309-0.93091.5243-0.1873-0.1465-0.90940.90520.24610.9288-0.5345-0.51710.12450.7593-0.2563-0.15231.5377-0.12841.3554-30.596324.5677-10.7588
1253.31373.2053-0.38112.78710.68734.0701-1.0898-0.2574-1.1421-0.48490.478-1.09350.60230.75080.60251.0829-0.014-0.02960.98030.06421.654918.79610.35435.6154
1262.87-1.44290.4451.771-1.0825.3325-0.0946-0.0560.58141.28910.25991.0636-1.1328-0.1273-0.01741.2477-0.02840.40070.694-0.23591.5159-12.711673.68848.2573
1270.64450.35310.09360.21690.02086.8746-0.4471-1.1393-0.79241.01710.0774-0.6278-1.2180.96050.47931.5450.01610.3410.8518-0.05651.6277-8.673574.347810.35
1285.3306-2.5925-1.78542.35790.45822.42890.27340.18790.39352.15490.47140.43390.5540.91710.0522.0555-0.327-0.10481.55780.06840.716-13.726664.095324.8632
1293.26290.8182-0.66962.7141-0.61250.24520.1680.2228-1.54070.3267-0.8621-1.14611.4226-0.0847-0.00791.2507-0.222-0.00261.32340.09410.9083-8.404962.859418.6322
1304.41331.09291.2232.9432.64962.71561.0017-1.2361-0.47420.0553-0.31770.09211.5608-0.63080.36130.96330.13610.11831.1975-0.05880.6852-12.239360.240511.7523
1310.65030.34180.45235.4489-2.03921.27520.4466-1.0757-0.0561.95971.20850.6044-1.097-0.2269-1.32782.1572-0.6475-0.082.1294-0.26870.7241-1.004152.004138.9666
1323.0848-0.4255-1.18322.72980.73976.3533-0.4362-1.5970.4359-1.9386-0.2556-1.5278-0.4563-3.4004-0.55261.5379-0.3587-0.00192.50110.07770.8824-4.369155.891239.3508
1331.8507-2.15990.79322.8862-0.72181.9888-0.13410.73210.27121.4270.11220.4083-1.0141-0.43250.09141.4890.01650.03871.2572-0.17630.9602-15.982762.784821.2579
1341.66080.11781.03050.41241.08793.12830.2241-1.2061.90060.8928-1.3467-2.0282-0.3870.5617-3.35441.5899-3.0222-1.50760.2945-0.6191.7014-2.237272.063237.275
1353.7426-2.354-1.98743.6553-0.94063.27650.81060.34452.59631.04690.0341-0.9083-4.95411.3926-0.56982.1709-0.01840.18431.5957-0.04770.8116-5.83767.518336.5707
1364.13241.6086-1.87853.26791.21442.24430.6911-1.0525-1.2411-0.66690.291.19711.5437-1.12790.09491.1654-0.1836-2.18412.6066-0.48190.34793.318153.117431.553
1373.13280.32160.44621.13590.11770.17541.5608-1.58391.83321.3599-1.60420.43340.0657-0.2798-0.87563.3542-0.87370.9210.5005-0.72771.67423.586567.825720.9405
1382.72110.645-1.20013.6680.89684.5153-0.8670.0760.10850.1146-0.2859-0.21160.4376-0.19260.31541.3506-0.06350.18351.70620.01730.95155.61157.761518.591
1395.51743.74491.3553.8794-1.05813.4452-1.12785.12291.877-2.68221.6568-1.34190.40180.6450.63721.9559-0.3249-0.51361.49260.5181.3621-13.384725.3502-46.0756
1400.09890.58520.1787.49994.3273.01410.0332-0.6578-0.4184-0.8313-0.7642-0.8623-0.2892-1.22120.81241.504-0.5153-0.59841.19580.26221.063-2.298816.7266-33.7885
1411.9996-5.3109-9.17544.75446.26389.0610.1992-3.4408-1.01582.27610.7649-0.64680.73141.2321-0.06682.29740.09330.31661.1950.56081.5074-4.771221.2637-44.2873
1428.2974-1.32623.69250.98821.07665.15450.41320.4235-1.90461.1365-1.31611.69590.4446-0.2066-1.60132.8283-0.6993-0.25081.011-0.51711.3663-7.859116.7638-54.3604
1436.80945.14612.02335.5989-2.11347.8776-0.20781.4629-0.0304-1.48211.7517-0.61120.04831.488-0.6563.30270.1718-0.14271.32440.18140.5662-1.148729.4012-57.1994
1444.70063.4843-2.02723.0329-2.07365.6623-0.8165-2.4432-0.1617-1.3926-0.6511-0.026-1.69791.74730.74162.1725-0.1681-0.11051.5492-0.2561.1571-3.227332.7579-45.6744
1452.7735-2.6697-2.79197.4303-0.73585.24020.69811.925-1.4976-2.51251.30930.35670.87481.3344-0.91022.0536-0.1725-0.58091.7925-0.40410.8099-3.579734.9937-53.1372
146-0.0061-0.20990.01553.72460.7740.105-1.07890.96960.546-2.51880.0842-0.88440.0872-0.163-3.46472.44890.1530.20941.3732-1.1340.07834.595525.2142-62.4041
1478.22712.9587-0.36861.0341-0.11720.01110.0248-1.71293.76170.0881-0.92781.1221-0.4265-0.1856-0.75563.6120.65390.13691.0118-0.49051.79269.967123.0366-46.5353
1483.5566-3.0284-2.15444.73465.63739.05051.0747-0.1087-0.4551.9551-0.32611.87571.28622.7931-0.14342.426-0.0980.41011.3868-0.14241.589212.41634.1711-44.7961
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain 'A' and (resid 38 through 44 )A38 - 44
2X-RAY DIFFRACTION2chain 'A' and (resid 45 through 55 )A45 - 55
3X-RAY DIFFRACTION3chain 'A' and (resid 56 through 63 )A56 - 63
4X-RAY DIFFRACTION4chain 'A' and (resid 64 through 77 )A64 - 77
5X-RAY DIFFRACTION5chain 'A' and (resid 78 through 85 )A78 - 85
6X-RAY DIFFRACTION6chain 'A' and (resid 86 through 113 )A86 - 113
7X-RAY DIFFRACTION7chain 'A' and (resid 114 through 120 )A114 - 120
8X-RAY DIFFRACTION8chain 'A' and (resid 121 through 134 )A121 - 134
9X-RAY DIFFRACTION9chain 'B' and (resid 18 through 30 )B18 - 30
10X-RAY DIFFRACTION10chain 'B' and (resid 31 through 49 )B31 - 49
11X-RAY DIFFRACTION11chain 'B' and (resid 50 through 82 )B50 - 82
12X-RAY DIFFRACTION12chain 'B' and (resid 83 through 93 )B83 - 93
13X-RAY DIFFRACTION13chain 'B' and (resid 94 through 101 )B94 - 101
14X-RAY DIFFRACTION14chain 'C' and (resid 15 through 26 )C15 - 26
15X-RAY DIFFRACTION15chain 'C' and (resid 27 through 35 )C27 - 35
16X-RAY DIFFRACTION16chain 'C' and (resid 36 through 72 )C36 - 72
17X-RAY DIFFRACTION17chain 'C' and (resid 73 through 118 )C73 - 118
18X-RAY DIFFRACTION18chain 'D' and (resid 32 through 48 )D32 - 48
19X-RAY DIFFRACTION19chain 'D' and (resid 49 through 90 )D49 - 90
20X-RAY DIFFRACTION20chain 'D' and (resid 91 through 124 )D91 - 124
21X-RAY DIFFRACTION21chain 'E' and (resid 40 through 63 )E40 - 63
22X-RAY DIFFRACTION22chain 'E' and (resid 64 through 85 )E64 - 85
23X-RAY DIFFRACTION23chain 'E' and (resid 86 through 120 )E86 - 120
24X-RAY DIFFRACTION24chain 'E' and (resid 121 through 134 )E121 - 134
25X-RAY DIFFRACTION25chain 'F' and (resid 18 through 24 )F18 - 24
26X-RAY DIFFRACTION26chain 'F' and (resid 25 through 40 )F25 - 40
27X-RAY DIFFRACTION27chain 'F' and (resid 41 through 75 )F41 - 75
28X-RAY DIFFRACTION28chain 'F' and (resid 76 through 93 )F76 - 93
29X-RAY DIFFRACTION29chain 'F' and (resid 94 through 100 )F94 - 100
30X-RAY DIFFRACTION30chain 'G' and (resid 12 through 16 )G12 - 16
31X-RAY DIFFRACTION31chain 'G' and (resid 17 through 26 )G17 - 26
32X-RAY DIFFRACTION32chain 'G' and (resid 27 through 35 )G27 - 35
33X-RAY DIFFRACTION33chain 'G' and (resid 36 through 46 )G36 - 46
34X-RAY DIFFRACTION34chain 'G' and (resid 47 through 72 )G47 - 72
35X-RAY DIFFRACTION35chain 'G' and (resid 73 through 79 )G73 - 79
36X-RAY DIFFRACTION36chain 'G' and (resid 80 through 96 )G80 - 96
37X-RAY DIFFRACTION37chain 'G' and (resid 97 through 111 )G97 - 111
38X-RAY DIFFRACTION38chain 'G' and (resid 112 through 118 )G112 - 118
39X-RAY DIFFRACTION39chain 'H' and (resid 32 through 37 )H32 - 37
40X-RAY DIFFRACTION40chain 'H' and (resid 38 through 48 )H38 - 48
41X-RAY DIFFRACTION41chain 'H' and (resid 49 through 55 )H49 - 55
42X-RAY DIFFRACTION42chain 'H' and (resid 56 through 83 )H56 - 83
43X-RAY DIFFRACTION43chain 'H' and (resid 84 through 90 )H84 - 90
44X-RAY DIFFRACTION44chain 'H' and (resid 91 through 103 )H91 - 103
45X-RAY DIFFRACTION45chain 'H' and (resid 104 through 124 )H104 - 124
46X-RAY DIFFRACTION46chain 'I' and (resid 2 through 91 )I2 - 91
47X-RAY DIFFRACTION47chain 'I' and (resid 92 through 147 )I92 - 147
48X-RAY DIFFRACTION48chain 'J' and (resid 1 through 30 )J1 - 30
49X-RAY DIFFRACTION49chain 'J' and (resid 31 through 90 )J31 - 90
50X-RAY DIFFRACTION50chain 'J' and (resid 91 through 120 )J91 - 120
51X-RAY DIFFRACTION51chain 'J' and (resid 121 through 147 )J121 - 147
52X-RAY DIFFRACTION52chain 'K' and (resid 2 through 21 )K2 - 21
53X-RAY DIFFRACTION53chain 'K' and (resid 22 through 65 )K22 - 65
54X-RAY DIFFRACTION54chain 'K' and (resid 66 through 149 )K66 - 149
55X-RAY DIFFRACTION55chain 'K' and (resid 150 through 160 )K150 - 160
56X-RAY DIFFRACTION56chain 'K' and (resid 161 through 177 )K161 - 177
57X-RAY DIFFRACTION57chain 'K' and (resid 178 through 213 )K178 - 213
58X-RAY DIFFRACTION58chain 'L' and (resid 2 through 16 )L2 - 16
59X-RAY DIFFRACTION59chain 'L' and (resid 17 through 37 )L17 - 37
60X-RAY DIFFRACTION60chain 'L' and (resid 38 through 58 )L38 - 58
61X-RAY DIFFRACTION61chain 'L' and (resid 59 through 89 )L59 - 89
62X-RAY DIFFRACTION62chain 'L' and (resid 90 through 116 )L90 - 116
63X-RAY DIFFRACTION63chain 'L' and (resid 117 through 126 )L117 - 126
64X-RAY DIFFRACTION64chain 'L' and (resid 127 through 142 )L127 - 142
65X-RAY DIFFRACTION65chain 'L' and (resid 143 through 160 )L143 - 160
66X-RAY DIFFRACTION66chain 'L' and (resid 161 through 177 )L161 - 177
67X-RAY DIFFRACTION67chain 'L' and (resid 178 through 188 )L178 - 188
68X-RAY DIFFRACTION68chain 'L' and (resid 189 through 198 )L189 - 198
69X-RAY DIFFRACTION69chain 'L' and (resid 199 through 213 )L199 - 213
70X-RAY DIFFRACTION70chain 'M' and (resid 37 through 44 )M37 - 44
71X-RAY DIFFRACTION71chain 'M' and (resid 45 through 55 )M45 - 55
72X-RAY DIFFRACTION72chain 'M' and (resid 56 through 85 )M56 - 85
73X-RAY DIFFRACTION73chain 'M' and (resid 86 through 113 )M86 - 113
74X-RAY DIFFRACTION74chain 'M' and (resid 114 through 120 )M114 - 120
75X-RAY DIFFRACTION75chain 'M' and (resid 121 through 134 )M121 - 134
76X-RAY DIFFRACTION76chain 'N' and (resid 18 through 24 )N18 - 24
77X-RAY DIFFRACTION77chain 'N' and (resid 25 through 40 )N25 - 40
78X-RAY DIFFRACTION78chain 'N' and (resid 41 through 82 )N41 - 82
79X-RAY DIFFRACTION79chain 'N' and (resid 83 through 101 )N83 - 101
80X-RAY DIFFRACTION80chain 'O' and (resid 12 through 26 )O12 - 26
81X-RAY DIFFRACTION81chain 'O' and (resid 27 through 35 )O27 - 35
82X-RAY DIFFRACTION82chain 'O' and (resid 36 through 46 )O36 - 46
83X-RAY DIFFRACTION83chain 'O' and (resid 47 through 72 )O47 - 72
84X-RAY DIFFRACTION84chain 'O' and (resid 73 through 79 )O73 - 79
85X-RAY DIFFRACTION85chain 'O' and (resid 80 through 89 )O80 - 89
86X-RAY DIFFRACTION86chain 'O' and (resid 90 through 111 )O90 - 111
87X-RAY DIFFRACTION87chain 'O' and (resid 112 through 118 )O112 - 118
88X-RAY DIFFRACTION88chain 'P' and (resid 32 through 55 )P32 - 55
89X-RAY DIFFRACTION89chain 'P' and (resid 56 through 83 )P56 - 83
90X-RAY DIFFRACTION90chain 'P' and (resid 84 through 90 )P84 - 90
91X-RAY DIFFRACTION91chain 'P' and (resid 91 through 103 )P91 - 103
92X-RAY DIFFRACTION92chain 'P' and (resid 104 through 124 )P104 - 124
93X-RAY DIFFRACTION93chain 'Q' and (resid 40 through 77 )Q40 - 77
94X-RAY DIFFRACTION94chain 'Q' and (resid 78 through 134 )Q78 - 134
95X-RAY DIFFRACTION95chain 'R' and (resid 22 through 30 )R22 - 30
96X-RAY DIFFRACTION96chain 'R' and (resid 31 through 48 )R31 - 48
97X-RAY DIFFRACTION97chain 'R' and (resid 49 through 82 )R49 - 82
98X-RAY DIFFRACTION98chain 'R' and (resid 83 through 92 )R83 - 92
99X-RAY DIFFRACTION99chain 'R' and (resid 93 through 101 )R93 - 101
100X-RAY DIFFRACTION100chain 'S' and (resid 12 through 26 )S12 - 26
101X-RAY DIFFRACTION101chain 'S' and (resid 27 through 35 )S27 - 35
102X-RAY DIFFRACTION102chain 'S' and (resid 36 through 46 )S36 - 46
103X-RAY DIFFRACTION103chain 'S' and (resid 47 through 72 )S47 - 72
104X-RAY DIFFRACTION104chain 'S' and (resid 73 through 79 )S73 - 79
105X-RAY DIFFRACTION105chain 'S' and (resid 80 through 96 )S80 - 96
106X-RAY DIFFRACTION106chain 'S' and (resid 97 through 106 )S97 - 106
107X-RAY DIFFRACTION107chain 'S' and (resid 107 through 111 )S107 - 111
108X-RAY DIFFRACTION108chain 'S' and (resid 112 through 118 )S112 - 118
109X-RAY DIFFRACTION109chain 'T' and (resid 32 through 37 )T32 - 37
110X-RAY DIFFRACTION110chain 'T' and (resid 38 through 48 )T38 - 48
111X-RAY DIFFRACTION111chain 'T' and (resid 49 through 55 )T49 - 55
112X-RAY DIFFRACTION112chain 'T' and (resid 56 through 83 )T56 - 83
113X-RAY DIFFRACTION113chain 'T' and (resid 84 through 90 )T84 - 90
114X-RAY DIFFRACTION114chain 'T' and (resid 91 through 104 )T91 - 104
115X-RAY DIFFRACTION115chain 'T' and (resid 105 through 124 )T105 - 124
116X-RAY DIFFRACTION116chain 'U' and (resid 2 through 21 )U2 - 21
117X-RAY DIFFRACTION117chain 'U' and (resid 22 through 71 )U22 - 71
118X-RAY DIFFRACTION118chain 'U' and (resid 72 through 111 )U72 - 111
119X-RAY DIFFRACTION119chain 'U' and (resid 112 through 147 )U112 - 147
120X-RAY DIFFRACTION120chain 'V' and (resid 1 through 30 )V1 - 30
121X-RAY DIFFRACTION121chain 'V' and (resid 31 through 50 )V31 - 50
122X-RAY DIFFRACTION122chain 'V' and (resid 51 through 80 )V51 - 80
123X-RAY DIFFRACTION123chain 'V' and (resid 81 through 110 )V81 - 110
124X-RAY DIFFRACTION124chain 'V' and (resid 111 through 130 )V111 - 130
125X-RAY DIFFRACTION125chain 'V' and (resid 131 through 147 )V131 - 147
126X-RAY DIFFRACTION126chain 'W' and (resid 2 through 30 )W2 - 30
127X-RAY DIFFRACTION127chain 'W' and (resid 31 through 47 )W31 - 47
128X-RAY DIFFRACTION128chain 'W' and (resid 48 through 65 )W48 - 65
129X-RAY DIFFRACTION129chain 'W' and (resid 66 through 76 )W66 - 76
130X-RAY DIFFRACTION130chain 'W' and (resid 77 through 89 )W77 - 89
131X-RAY DIFFRACTION131chain 'W' and (resid 90 through 116 )W90 - 116
132X-RAY DIFFRACTION132chain 'W' and (resid 117 through 137 )W117 - 137
133X-RAY DIFFRACTION133chain 'W' and (resid 138 through 149 )W138 - 149
134X-RAY DIFFRACTION134chain 'W' and (resid 150 through 161 )W150 - 161
135X-RAY DIFFRACTION135chain 'W' and (resid 162 through 176 )W162 - 176
136X-RAY DIFFRACTION136chain 'W' and (resid 177 through 188 )W177 - 188
137X-RAY DIFFRACTION137chain 'W' and (resid 189 through 200 )W189 - 200
138X-RAY DIFFRACTION138chain 'W' and (resid 201 through 212 )W201 - 212
139X-RAY DIFFRACTION139chain 'X' and (resid 2 through 16 )X2 - 16
140X-RAY DIFFRACTION140chain 'X' and (resid 17 through 37 )X17 - 37
141X-RAY DIFFRACTION141chain 'X' and (resid 38 through 42 )X38 - 42
142X-RAY DIFFRACTION142chain 'X' and (resid 45 through 49 )X45 - 49
143X-RAY DIFFRACTION143chain 'X' and (resid 50 through 68 )X50 - 68
144X-RAY DIFFRACTION144chain 'X' and (resid 69 through 89 )X69 - 89
145X-RAY DIFFRACTION145chain 'X' and (resid 90 through 145 )X90 - 145
146X-RAY DIFFRACTION146chain 'X' and (resid 146 through 189 )X146 - 189
147X-RAY DIFFRACTION147chain 'X' and (resid 190 through 200 )X190 - 200
148X-RAY DIFFRACTION148chain 'X' and (resid 201 through 211 )X201 - 211

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