[English] 日本語
Yorodumi
- PDB-6om3: Crystal structure of the Orc1 BAH domain in complex with a nucleo... -

+
Open data


ID or keywords:

Loading...

-
Basic information

Entry
Database: PDB / ID: 6om3
TitleCrystal structure of the Orc1 BAH domain in complex with a nucleosome core particle
Components
  • DNA (146-MER)
  • DNA (147-MER)
  • Histone H2A
  • Histone H2B 1.1
  • Histone H3.2
  • Histone H4
  • Origin recognition complex subunit 1
KeywordsStructural Protein/DNA / Chromatin Modifier / Structural Protein / Structural Protein-DNA complex
Function / homology
Function and homology information


CDC6 association with the ORC:origin complex / Assembly of the ORC complex at the origin of replication / Orc1 removal from chromatin / maintenance of rDNA / nuclear origin of replication recognition complex / pre-replicative complex assembly involved in nuclear cell cycle DNA replication / Activation of the pre-replicative complex / nuclear pre-replicative complex / Activation of ATR in response to replication stress / DNA replication preinitiation complex ...CDC6 association with the ORC:origin complex / Assembly of the ORC complex at the origin of replication / Orc1 removal from chromatin / maintenance of rDNA / nuclear origin of replication recognition complex / pre-replicative complex assembly involved in nuclear cell cycle DNA replication / Activation of the pre-replicative complex / nuclear pre-replicative complex / Activation of ATR in response to replication stress / DNA replication preinitiation complex / mitotic DNA replication checkpoint signaling / silent mating-type cassette heterochromatin formation / DNA replication origin binding / DNA replication initiation / nucleosome binding / structural constituent of chromatin / nucleosome / protein heterodimerization activity / chromatin binding / ATP hydrolysis activity / DNA binding / nucleoplasm / ATP binding / metal ion binding / nucleus
Similarity search - Function
Bromo adjacent homology (BAH) domain / : / Origin recognition complex subunit 1 C-terminal winged HTH domain / AAA lid domain / AAA lid domain / Bromo adjacent homology (BAH) domain superfamily / Bromo adjacent homology domain / Bromo adjacent homology (BAH) domain / BAH domain / BAH domain profile. ...Bromo adjacent homology (BAH) domain / : / Origin recognition complex subunit 1 C-terminal winged HTH domain / AAA lid domain / AAA lid domain / Bromo adjacent homology (BAH) domain superfamily / Bromo adjacent homology domain / Bromo adjacent homology (BAH) domain / BAH domain / BAH domain profile. / Histone, subunit A / Histone, subunit A / Histone H2B signature. / Histone H2B / Histone H2B / Histone H2A conserved site / Histone H2A signature. / Histone H2A, C-terminal domain / C-terminus of histone H2A / Histone H2A / Histone 2A / Histone H4, conserved site / Histone H4 signature. / Histone H4 / Histone H4 / CENP-T/Histone H4, histone fold / Centromere kinetochore component CENP-T histone fold / TATA box binding protein associated factor / TATA box binding protein associated factor (TAF), histone-like fold domain / ATPase family associated with various cellular activities (AAA) / Histone H3 signature 1. / ATPase, AAA-type, core / Histone H3 signature 2. / Histone H3 / Histone H3/CENP-A / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 / SH3 type barrels. / Histone-fold / Roll / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / Mainly Beta / Mainly Alpha
Similarity search - Domain/homology
DNA / DNA (> 10) / DNA (> 100) / Histone H2B 1.1 / Histone H2A type 1 / Origin recognition complex subunit 1 / Histone H4 / Histone H3.2 / Histone H2A
Similarity search - Component
Biological speciesXenopus laevis (African clawed frog)
Saccharomyces cerevisiae (brewer's yeast)
synthetic construct (others)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.3 Å
AuthorsDe Ioannes, P.E. / Wang, M. / Armache, K.-J.
Funding support United States, 2items
OrganizationGrant numberCountry
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)R01GM115882 United States
Other privateThe David and Lucile Packard Foundation United States
CitationJournal: Nat Commun / Year: 2019
Title: Structure and function of the Orc1 BAH-nucleosome complex.
Authors: De Ioannes, P. / Leon, V.A. / Kuang, Z. / Wang, M. / Boeke, J.D. / Hochwagen, A. / Armache, K.J.
History
DepositionApr 18, 2019Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jul 10, 2019Provider: repository / Type: Initial release
Revision 1.1Jul 17, 2019Group: Data collection / Database references / Category: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name
Revision 1.2Jan 1, 2020Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization
Revision 1.3Oct 11, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

-
Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

-
Assembly

Deposited unit
A: Histone H3.2
B: Histone H4
C: Histone H2A
D: Histone H2B 1.1
E: Histone H3.2
F: Histone H4
G: Histone H2A
H: Histone H2B 1.1
I: DNA (146-MER)
J: DNA (147-MER)
K: Origin recognition complex subunit 1
L: Origin recognition complex subunit 1
M: Histone H3.2
N: Histone H4
O: Histone H2A
P: Histone H2B 1.1
Q: Histone H3.2
R: Histone H4
S: Histone H2A
T: Histone H2B 1.1
U: DNA (146-MER)
V: DNA (147-MER)
W: Origin recognition complex subunit 1
X: Origin recognition complex subunit 1


Theoretical massNumber of molelcules
Total (without water)504,28624
Polymers504,28624
Non-polymers00
Water0
1
A: Histone H3.2
B: Histone H4
C: Histone H2A
D: Histone H2B 1.1
E: Histone H3.2
F: Histone H4
G: Histone H2A
H: Histone H2B 1.1
I: DNA (146-MER)
J: DNA (147-MER)
K: Origin recognition complex subunit 1
L: Origin recognition complex subunit 1


Theoretical massNumber of molelcules
Total (without water)252,14312
Polymers252,14312
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
M: Histone H3.2
N: Histone H4
O: Histone H2A
P: Histone H2B 1.1
Q: Histone H3.2
R: Histone H4
S: Histone H2A
T: Histone H2B 1.1
U: DNA (146-MER)
V: DNA (147-MER)
W: Origin recognition complex subunit 1
X: Origin recognition complex subunit 1


Theoretical massNumber of molelcules
Total (without water)252,14312
Polymers252,14312
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)100.254, 166.428, 168.277
Angle α, β, γ (deg.)90.000, 90.280, 90.000
Int Tables number4
Space group name H-MP1211

-
Components

-
Protein , 5 types, 20 molecules AEMQBFNRCGOSDHPTKLWX

#1: Protein
Histone H3.2


Mass: 15303.930 Da / Num. of mol.: 4 / Mutation: G102A
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Xenopus laevis (African clawed frog) / Production host: Escherichia coli (E. coli) / References: UniProt: P84233
#2: Protein
Histone H4 /


Mass: 11394.426 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Xenopus laevis (African clawed frog) / Production host: Escherichia coli (E. coli) / References: UniProt: P62799
#3: Protein
Histone H2A /


Mass: 14109.436 Da / Num. of mol.: 4 / Mutation: G99R, S123A
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Xenopus laevis (African clawed frog) / Gene: hist1h2aj, LOC494591, XELAEV_18003602mg / Variant: ATCC 204508 / S288c / Production host: Escherichia coli (E. coli) / References: UniProt: Q6AZJ8, UniProt: P06897*PLUS
#4: Protein
Histone H2B 1.1 / H2B1.1


Mass: 13979.291 Da / Num. of mol.: 4 / Mutation: S32T
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Xenopus laevis (African clawed frog) / Production host: Escherichia coli (E. coli) / References: UniProt: P02281
#7: Protein
Origin recognition complex subunit 1 / / Origin recognition complex 120 kDa subunit


Mass: 26067.488 Da / Num. of mol.: 4 / Mutation: L79I
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Strain: ATCC 204508 / S288c / Gene: ORC1, YML065W / Variant: ATCC 204508 / S288c / Production host: Spodoptera frugiperda (fall armyworm) / References: UniProt: P54784

-
DNA chain , 2 types, 4 molecules IUJV

#5: DNA chain DNA (146-MER)


Mass: 44824.570 Da / Num. of mol.: 2 / Source method: obtained synthetically / Source: (synth.) synthetic construct (others)
#6: DNA chain DNA (147-MER)


Mass: 45609.055 Da / Num. of mol.: 2 / Source method: obtained synthetically / Source: (synth.) synthetic construct (others)

-
Experimental details

-
Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

-
Sample preparation

CrystalDensity Matthews: 2.8 Å3/Da / Density % sol: 60.48 %
Crystal growTemperature: 277.15 K / Method: vapor diffusion, sitting drop / pH: 6
Details: 6 mM Na-Cacodylate pH 6.0, 0.4 mM Spermine-HCl, 2 mM MgCl2 and 1.75% v/v PEG 400

-
Data collection

DiffractionMean temperature: 110 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 24-ID-C / Wavelength: 0.9791 Å
DetectorType: DECTRIS PILATUS 6M-F / Detector: PIXEL / Date: Oct 29, 2017
Details: Cryogenically-cooled single crystal Si(220) side bounce monochromator
RadiationMonochromator: Cryo-Cooled double crystal / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9791 Å / Relative weight: 1
ReflectionResolution: 3.3→50 Å / Num. obs: 81623 / % possible obs: 97.9 % / Redundancy: 3 % / Biso Wilson estimate: 112.42 Å2 / Rmerge(I) obs: 0.117 / Rpim(I) all: 0.079 / Rrim(I) all: 0.142 / Χ2: 1.264 / Net I/σ(I): 5.2 / Num. measured all: 248201
Reflection shell

Diffraction-ID: 1

Resolution (Å)Redundancy (%)Rmerge(I) obsNum. unique obsCC1/2Rpim(I) allRrim(I) allΧ2% possible all
3.3-3.3630.83740730.4850.5661.0140.51498.1
3.36-3.4230.72740470.5460.490.8810.53798.3
3.42-3.4830.62241160.5990.420.7540.61498.2
3.48-3.5530.53940180.6650.3620.6520.66598
3.55-3.6330.4540540.7240.3070.5470.75497.6
3.63-3.722.90.41540740.7420.2850.5060.78497.3
3.72-3.812.70.35739670.7620.2540.440.97595.9
3.81-3.913.10.30841280.8350.2080.3730.99999
3.91-4.033.20.25441250.890.170.3071.10898.8
4.03-4.163.20.22541150.9010.1510.2731.19399.1
4.16-4.313.20.18941030.9110.1280.2291.33598.8
4.31-4.483.10.16440930.9370.1110.1981.39798.5
4.48-4.683.10.14940560.9450.1020.1811.46397.5
4.68-4.932.90.13340360.9580.0930.1631.596.5
4.93-5.2430.12540400.960.0860.1521.62596.9
5.24-5.643.20.11441030.9610.0770.1381.48998.3
5.64-6.213.20.10241170.9680.0690.1241.48598.5
6.21-7.130.08740960.9770.0610.1071.5597.5
7.1-8.9430.07840990.9790.0530.0942.08197.5
8.94-5030.08141630.9860.0540.0982.98897.3

-
Processing

Software
NameVersionClassification
PHENIX12-2829refinement
HKL-2000HKL2000_v718-Macdata scaling
PDB_EXTRACT3.24data extraction
HKL-2000HKL2000_v718-Macdata reduction
PHASER2.8.0phasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 3tu4, 1M4Z, 3LZ1

3tu4

1m4z

3lz1


Resolution: 3.3→49.054 Å / SU ML: 0.5 / Cross valid method: THROUGHOUT / σ(F): 1.36 / Phase error: 27.11
RfactorNum. reflection% reflection
Rfree0.2497 8111 9.99 %
Rwork0.213 --
obs0.2167 81181 97.81 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å
Displacement parametersBiso max: 381.68 Å2 / Biso mean: 133.4376 Å2 / Biso min: 44.93 Å2
Refinement stepCycle: final / Resolution: 3.3→49.054 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms16894 12012 0 0 28906
Num. residues----2782
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00330592
X-RAY DIFFRACTIONf_angle_d0.55543919
X-RAY DIFFRACTIONf_chiral_restr0.0365058
X-RAY DIFFRACTIONf_plane_restr0.0043552
X-RAY DIFFRACTIONf_dihedral_angle_d22.34516292
LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Rfactor Rfree error: 0 / Total num. of bins used: 30

Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkNum. reflection all% reflection obs (%)
3.3-3.33750.33412730.32642440271397
3.3375-3.37670.3552670.32182391265898
3.3767-3.41790.34612690.31492434270398
3.4179-3.46120.34922650.30442427269298
3.4612-3.50670.31942750.29362455273098
3.5067-3.55470.3242720.29172405267798
3.5547-3.60550.30852560.27642449270598
3.6055-3.65930.32532630.29562412267598
3.6593-3.71650.32572750.2842428270397
3.7165-3.77740.29672620.27262386264896
3.7774-3.84250.31742620.26922422268497
3.8425-3.91230.29532770.26562441271899
3.9123-3.98750.27512720.24942448272099
3.9875-4.06890.26692680.24492460272899
4.0689-4.15730.27582840.23822471275599
4.1573-4.2540.2742620.2312433269599
4.254-4.36030.26942810.22872496277799
4.3603-4.47810.27272690.22452399266898
4.4781-4.60980.2532690.21892430269998
4.6098-4.75850.24812590.2112464272397
4.7585-4.92840.24692810.20632354263596
4.9284-5.12550.24922670.20262383265096
5.1255-5.35850.23462800.20952462274299
5.3585-5.64060.2572660.21312443270998
5.6406-5.99350.25482720.21162460273299
5.9935-6.45530.26472800.21792450273098
6.4553-7.10320.26422680.21532439270797
7.1032-8.1270.21772750.17252434270997
8.127-10.22390.20062760.15712465274198
10.2239-49.05980.16892660.152489275597
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
19.2358-1.12485.34851.2608-0.36148.57360.35090.752-1.0171-0.446-0.6327-0.94380.55261.059-0.32051.9999-0.4916-0.4157-0.2196-0.00031.2779-84.667910.6122-114.2865
22.1444-0.3866-1.18891.87221.30481.3401-0.8106-0.1020.6176-0.6016-0.50560.19061.5226-0.8209-0.38521.0473-0.2601-0.1971.1580.4660.8403-71.387513.1414-109.7763
35.16150.9164-4.20556.5419-2.32053.83290.0551-0.6078-0.4769-1.46851.33970.31351.9535-0.4061-0.5121.3141-0.1553-0.18450.9460.02850.7246-59.701415.9756-115.8301
43.49980.4561-0.14072.7975-0.16971.54010.25580.7971-0.1389-2.55980.34760.3545-0.06651.3477-0.31391.0994-0.2261-0.08341.0563-0.05840.8855-52.531328.7116-126.0232
56.3698-4.03650.74893.62390.09310.47160.22143.3581-0.4159-2.3759-1.8146-0.6409-0.61870.0499-0.63761.325-0.06520.13480.7321-0.12660.6183-42.517931.2489-126.6821
68.437-1.4659-5.86924.65970.48354.7998-0.807-1.0538-1.67280.09830.28850.86771.13960.2253-0.24360.6975-0.1463-0.17331.1744-0.20460.7846-59.86825.7808-109.4086
71.29930.6479-0.80314.76852.03335.19311.8726-0.20492.78291.04760.04050.4399-0.057-0.57180.35840.4116-0.53580.06661.54190.1511.1099-77.131130.1449-104.7323
84.0928-1.00490.41932.55532.45014.39470.7987-0.12670.9424-1.1922-0.2727-1.9252-1.69951.33470.31550.9349-0.33670.2230.7128-0.32971.6025-64.917937.5182-105.4332
95.21072.7971-6.16991.5254-2.99598.3314-0.03281.0153-0.2415-1.2041-0.1660.22871.13780.0903-0.29841.4598-0.2145-0.33261.15240.35430.8736-56.766630.0568-131.2625
101.95880.2113-1.17883.0539-0.30525.7813-0.59530.9369-0.56070.47111.03160.8470.8155-1.746-0.38960.6788-0.0524-0.21360.81990.23781.0246-70.359122.9497-113.3389
112.60752.9703-0.42733.5109-0.47083.30310.3582.03811.3665-0.54040.3581-0.0873-0.19550.0329-0.57590.78760.03550.05760.84450.0530.7394-49.366233.3532-118.138
126.33050.1119-1.18317.624.10445.7336-0.5449-1.43650.0951-0.14490.3423-0.7874-1.69151.878-0.161.1471-0.2403-0.0420.80.06790.5713-42.640129.6539-110.7701
132.08621.33870.99023.45933.37523.36241.8739-0.6054-0.6039-0.488-1.93170.67271.1357-0.76040.30811.30980.01110.07860.8384-0.00140.7739-46.075623.7504-107.3812
142.8997-1.9153.41356.1857-1.20334.24280.0914-0.211-1.87261.15780.2497-0.46640.3245-1.0328-0.34971.6352-0.52780.06990.5047-0.14520.7411-25.005859.3613-105.6108
155.31475.189-2.68475.1732-2.59051.5161-0.3628-1.778-0.00372.3171-0.9516-3.092-0.64350.9732-0.3850.8878-0.083-0.12731.1002-0.27790.9376-24.668248.7902-99.7666
164.2502-1.8464-0.25623.29752.16986.15951.2846-0.33410.8054-0.8128-0.8824-0.3144-1.3891.0728-0.43420.9217-0.33080.27320.58450.04321.0819-36.514753.4519-104.4714
175.4736-0.286-0.57821.4980.83230.69070.281-0.3890.6033-0.3508-0.05990.1822-0.6817-0.2065-0.04071.0063-0.06540.17420.905-0.2980.9567-57.148154.8166-97.8616
182.9756-0.3526-0.0562.8090.04833.7739-0.4721-0.36130.87010.7349-0.0391-0.9068-1.73380.52590.26581.0405-0.17780.16371.3507-0.03341.3541-32.910860.6342-94.9913
192.1956-0.6055-0.43765.35190.47123.61090.2655-0.28910.0365-0.3150.14620.6871-0.8150.7562-0.26750.8565-0.1782-0.00180.5474-0.08350.7563-36.473447.5094-101.3492
205.9927-0.1609-0.56731.64532.20552.63670.31141.18290.5539-0.4505-0.6101-0.1963-0.50890.12270.30070.8166-0.16090.12080.79920.05590.7818-34.740750.3646-113.9451
211.9795-1.4210.00811.17930.23171.61990.82550.45471.95870.1271-0.24960.8295-1.21570.0294-0.18111.41040.24230.42070.4180.11931.7627-70.101856.8031-85.7554
225.39090.54460.77732.31460.6411.93370.2523-1.9847-0.10921.0195-0.5841-0.204-0.1305-0.7772-0.16231.4273-0.05940.0561.0975-0.11330.5682-48.876640.4968-71.445
236.2924-0.99044.78674.6662-0.71262.4470.34210.72641.1538-0.1341-0.4020.0493-0.77220.4924-0.13910.7268-0.02230.33021.0949-0.18320.8137-63.413343.6219-89.3398
247.8337-0.5313-1.17454.09770.28256.1520.6639-1.1064-0.7150.8903-0.20990.49090.38380.9307-0.41230.83950.00930.0280.8016-0.09760.8002-64.976732.8836-92.4307
251.22230.14091.26290.5533-0.36051.74550.22830.0953-0.5921-0.0974-0.4227-0.0642-0.8583-0.27460.31252.07821.9297-0.6202-1.21450.47470.66-53.726838.6267-62.0477
266.3492-1.80990.57545.49292.87972.05520.2043-0.48830.82520.5599-0.20070.0937-0.6123-2.0837-0.081.13260.10.3171.0658-0.36751.0304-65.088246.8938-79.3705
278.0368-0.67022.21370.6851-1.6682.72550.7675-0.482-2.56850.09220.00981.03220.34990.0346-0.60870.827-0.16420.14030.6209-0.12521.1326-57.533637.8989-81.9681
284.2466-2.30065.31654.0975-1.18497.49710.45-1.19551.0507-0.2744-0.2597-1.02531.0549-0.175-0.58270.743-0.28020.15170.9359-0.20581.0516-40.074140.0916-82.3479
293.0681-1.8128-3.47184.6849-1.05846.64041.2014-0.62160.27650.6104-0.30270.0679-0.55330.0041-0.97751.1702-0.19540.06970.7038-0.03550.837-46.595146.1703-90.4291
300.14050.8194-0.23884.8117-1.11751.7847-0.45880.2172-0.2822-0.31430.1176-1.3050.05660.3162-1.26011.9542-0.32590.06190.32-1.40022.6076-14.68097.5644-92.6059
313.7728-1.7218-2.66394.36592.05672.08860.1957-0.67760.91763.21570.9705-1.6208-1.0821-0.8987-1.07111.65350.4937-0.15621.11750.39581.4529-26.496810.6585-91.4306
324.1745-2.3970.58173.2131-2.40982.4846-0.0858-1.75310.65-1.42260.1875-2.02240.65770.14590.31480.8054-0.0686-0.07121.1091-0.22411.0692-24.688220.9384-97.4828
333.0222-5.503-2.09562.0282.7346.2010.8701-2.3332-1.7637-0.50761.0825-0.6645-0.9653-0.3407-1.13190.7744-0.2609-0.28720.87420.1340.9798-24.224628.8618-94.0207
343.0548-1.986-0.20053.47571.2074.11570.4292-1.0704-1.72990.2549-0.1852-0.96911.9233-0.3084-0.3241.24160.0771-0.16770.54460.2120.7717-41.404211.8988-92.9205
355.28232.01811.81733.4457-3.00485.78320.405-0.6955-0.6056-1.9248-1.48971.29081.8311-0.96030.48941.4133-0.0829-0.48041.029-0.0520.7329-50.54651.8696-104.9632
363.65480.60231.19024.8949-0.07480.56730.7375-0.73820.56280.8395-0.5547-0.46091.2177-0.2708-0.24061.0719-0.1975-0.09080.7029-0.08030.7131-52.728315.7811-96.678
377.71381.36940.34483.1366-1.42513.9012-0.45291.75370.13831.02641.08151.21361.14850.2224-0.13030.9016-0.0568-0.17860.61930.00120.8258-56.055119.0222-102.8774
380.44560.6855-0.18762.14851.25332.03720.854-0.0796-0.2315-1.3455-0.61650.1093-0.2011-0.7805-0.48781.2321-0.0248-0.15090.9850.10541.4405-77.435318.3935-99.2787
393.5408-0.6413-3.8095.64613.03711.99450.46471.55321.7467-2.0767-0.414-0.0761-1.22112.48911.12710.56670.4191-1.18741.70110.69920.3458-28.555815.4606-108.8644
402.5880.4974-3.50897.13060.07111.97780.9825-1.1617-0.790.60890.8806-1.35291.0312-1.3643-1.28981.27790.0977-0.25190.72210.19191.0246-36.20075.3517-98.6799
414.8034-0.3029-2.25670.087-0.05234.9332-0.1923-0.3525-1.7905-1.3073-1.49890.18161.5583-0.35880.05211.55230.0492-0.12561.01060.16280.8098-43.67270.9997-100.8579
424.58131.45491.07253.5135-0.90924.27070.05230.24490.4499-1.0392-0.4230.0365-0.57960.29340.29850.48590.05010.0210.69050.00240.7716-37.477324.2594-97.5352
434.81960.3674-0.97991.97160.95771.91280.5245-0.84670.22470.9959-1.8854-0.88870.60960.823-0.21481.1827-0.0156-0.28241.261-0.16891.105-25.943534.2318-85.7313
442.12582.77090.97868.99420.4367.77151.2518-0.3641.01320.7724-0.64-0.080.4502-0.4209-0.24760.7239-0.12240.04830.7007-0.10120.7475-37.088426.0328-85.0509
451.57150.21390.94455.50620.53290.6160.9769-1.2829-0.40132.5102-0.8620.7926-0.190.2378-0.33360.88360.3181-0.29641.59290.38860.3815-33.481415.0624-82.6936
461.64610.51870.24991.9158-0.07362.1570.2923-0.4049-0.04030.1666-0.05210.20030.2972-0.0918-0.24091.0679-0.1065-0.02581.00550.12580.8555-55.280125.2329-95.918
474.47820.8633-0.33443.08730.38241.68820.5591-0.22250.56020.0585-0.0456-0.4768-0.2730.4733-0.41441.09740.0797-0.02430.90090.39720.4527-39.873850.2801-102.8555
48-0.18620.00060.14972.1109-0.00690.0425-0.30040.0498-0.08070.52450.11730.2929-0.71030.06870.14812.0202-0.0590.04751.3755-0.18631.3824-53.389170.3522-86.6124
493.68250.3551-0.70632.41770.97732.5749-0.22550.1179-0.1947-0.280.24530.2170.18650.1355-0.02691.04520.1337-0.10430.6830.35430.7714-57.003632.3182-109.8382
502.8117-0.1360.73232.03260.17070.8088-0.2411-0.40861.09540.84930.3472-0.9558-0.171.1274-0.33211.5732-0.3105-0.26181.6305-0.04351.1895-25.298438.9974-77.9075
512.65313.0291-1.19062.29540.35741.32-0.46550.5644-0.8328-0.68110.4094-0.42450.61960.01560.00861.84460.0426-0.23451.08620.15130.8551-57.0792-0.6537-112.3663
521.719-1.9568-0.31754.0615-0.46583.9981-1.365-0.2677-0.68571.09420.7083-0.05680.3005-0.79380.371.12240.007-0.06290.9135-0.02761.1823-36.833657.0198-128.8396
530.5117-1.00481.43812.9152-1.6354.1558-0.04480.1591-0.1082-0.8866-0.3648-0.3794-0.0532-0.52420.29260.9884-0.14860.05540.64420.02560.778-41.091755.373-131.4606
541.56661.64983.02664.21780.3643.88910.38680.45120.28670.3696-0.0560.0752-0.0481-0.1903-0.27050.7745-0.05350.09110.8330.0170.7911-43.11944.5597-139.4564
550.6378-1.02120.4581.8096-1.36875.9991-0.46812.2436-0.1379-0.0064-0.73750.6376-0.4416-0.64120.04471.1350.374-0.09851.18240.21490.9519-54.179254.5945-152.7541
565.7229-1.9425-0.29564.06810.98780.32090.9982-0.1372-0.54010.3123-1.59740.3182-0.91631.3604-0.04821.1829-0.1256-0.0121.35440.30640.7107-49.988751.0797-153.0595
573.65542.17952.61866.11144.60863.87510.4953-0.5362-0.496-0.3028-0.85970.4905-0.1876-1.76030.22591.0708-0.01990.11771.23110.18261.3042-57.364345.2608-137.2361
583.71441.5802-3.42147.443-1.53554.6594-0.06150.07560.34311.08261.18910.8581-0.0421.8991-0.03031.5940.2624-0.2481.3328-0.0710.6423-31.801216.1846-66.9405
591.9629-0.64620.02595.0453-4.54338.84910.65590.0380.6179-1.90040.30020.4329-0.60050.0053-0.2330.9592-0.0821-0.19210.80470.11211.445-45.14777.2231-78.1246
602.0602-0.6132-1.70047.06961.35371.91350.0144-0.91440.184-1.10670.46260.1777-0.34850.95650.69841.76850.108-0.11061.5520.0150.986-40.317814.2647-59.9968
613.617-3.0027-4.37954.87070.73339.07280.2956-0.61730.20060.1893-0.57640.1213-1.55480.65030.21091.5016-0.1467-0.2111.29560.07850.7949-41.041725.3551-62.9239
62-0.0702-0.4079-0.16562.78941.3931.5907-0.7294-0.001-0.5899-0.45870.80210.99530.3408-0.74650.01042.0461-0.25320.22741.38910.11240.8111-55.189635.1857-44.7537
633.81230.198-2.60221.20320.29581.97280.61281.90.47060.793-0.02220.2486-0.1858-1.45981.35943.1287-0.64130.06931.2424-0.14710.0873-54.164537.6912-35.6091
643.00010.4207-2.8797-0.0307-0.43422.5739-1.05482.30540.65371.3547-0.06280.19922.1163-2.58920.18992.0016-0.15110.18151.36550.16931.1304-48.765727.3791-52.2828
652.6104-2.1402-0.5432.2631-0.83473.8247-0.0814-0.71011.17752.8556-0.40680.42680.65761.81650.12772.9022-0.38610.07530.9374-0.35130.7341-46.213717.433-50.1861
663.987-3.20291.07458.7952-3.22996.27240.54642.2224-0.05672.964-0.56282.57910.14780.57440.2132.0437-0.02460.08361.27450.22641.1032-50.509319.0354-44.6479
676.3189-1.0731-0.66631.27781.43936.2894-0.94220.5818-0.5590.8941-0.9322-0.0426-0.2977-1.4933-0.26881.9464-0.22260.481.0941-0.00881.6644-59.078531.1625-53.1792
688.3392-4.13852.0476.0106-0.81240.4903-0.29840.4859-1.2076-1.08911.0823-0.6310.94680.5115-0.22392.5135-0.63080.13431.7366-0.30981.7087-56.221716.1152-60.0761
690.8972-1.2251-0.01311.65160.16240.1403-0.19570.0731-0.4848-0.8256-0.74540.0906-0.6683-0.3558-0.3661.5366-0.2826-0.16531.1634-0.21381.1377-58.641225.9315-65.7001
705.10622.31921.08043.5577-2.72244.70271.09880.25521.3765-0.20120.80040.78090.80850.0128-2.19010.7520.4028-0.08871.3316-0.07181.413332.3621.85828.6277
714.4862-3.3681.96763.5188-0.153.076-0.79290.1082-2.03360.3871-0.4667-0.74512.48560.7180.59150.88070.00630.0460.77110.240.859119.029424.47871.2592
725.07650.1307-3.11622.78981.23832.4362-0.2853-0.6893-0.19380.64960.4547-0.0978-0.2020.8907-0.03650.61640.0756-0.10831.30130.18660.7478-1.471140.15110.3296
738.7343-1.3998-2.92042.8017-0.82172.9066-0.15450.5092-1.6258-0.0958-0.0982-0.36930.234-0.28880.37640.54370.07260.03740.86480.08940.91338.712437.6916-2.2012
743.5649-0.06170.39464.26371.28464.57460.49110.70762.21011.10060.5744-0.2748-0.75580.60780.47940.6130.29190.18181.09520.32341.041126.969540.3739-4.4904
755.6687-2.32481.88272.8699-1.92038.47940.10560.15321.54840.12780.38920.3614-1.0782-0.26560.55360.80080.1075-0.20570.58010.2910.872215.434348.249-6.678
762.1891-2.9754-2.95744.36084.3145.3023-1.74140.30690.28391.9003-0.1187-1.82240.37822.44521.24951.52580.17310.07692.21090.30281.4693-0.234446.951922.1661
771.94420.47960.79662.79170.95073.4485-0.1404-0.3601-0.73770.3763-0.2240.29060.79030.81980.24110.54980.0451-0.0981.21040.17870.71613.060236.07737.8171
784.29850.2752-1.26372.0649-0.78332.0611-0.2209-0.18130.71070.34460.295-0.2423-0.3965-0.09110.00640.49910.0328-0.07080.74010.03280.59772.381545.12863.6541
797.6023-3.0926-1.29239.82192.2047.71140.16481.5294-1.0342-0.3835-0.5411.6028-1.0891-0.70370.48690.61710.0083-0.07590.6652-0.08820.7641-6.662840.1957-4.8614
806.1002-5.5355-5.45954.98644.90884.9066-0.64091.34150.65610.1140.53250.0866-1.9234-0.5163-0.28841.18620.19810.03341.11930.10681.3678-23.583274.1881-15.0338
811.0603-1.73380.27173.7492-1.09860.5514-0.4557-0.131-0.4339-1.17452.51122.2413-0.4329-1.4702-0.69980.719-0.1693-0.26881.07670.13570.7716-22.288262.1974-19.2886
825.5105-0.4418-3.73738.1160.62074.68370.1723-0.26840.74430.50371.7624-0.67091.3556-0.1606-1.38060.5107-0.0214-0.16010.6895-0.22010.9194-24.469154.3078-15.3911
833.75241.0279-4.23662.3237-3.20856.42720.8748-1.08141.51650.618-0.89081.3065-0.94891.17510.08270.65130.04990.03010.6230.09641.0423-5.619271.0006-12.8143
841.99486.46270.54225.98950.7870.1289-1.16430.4104-3.34250.09441.4264-1.8213-1.7253-0.14130.09861.0787-0.1883-0.15951.25830.34191.00415.98678.5662-24.0793
853.57731.4-1.40866.6001-2.14191.56550.02140.9089-1.3541.33230.29510.83560.1164-0.1236-0.23910.47170.2130.1460.85030.34290.82646.997767.8871-18.2471
866.47881.18861.92875.0649-3.89494.040.2095-0.16340.1272-0.48150.0893-0.25580.31290.8971-0.01480.42870.0411-0.02010.79390.05030.70147.079161.6341-16.1461
879.61671.23995.38674.124-1.80564.658-1.75430.111.54962.3775-0.89041.7209-0.1608-0.7180.83541.0658-0.23680.36261.08650.06050.8430.338361.3852-12.9519
884.2788-2.6684-0.65733.2232-0.45746.7755-0.02760.95170.2977-0.71850.0415-0.2142-1.3479-0.19740.02690.5810.01150.1520.8560.080.7287-9.333574.892-22.913
893.64845.7487-2.33437.5582-3.14793.9008-0.42580.5853-0.7193-2.0080.3611-0.10660.7284-0.5680.19120.60960.1219-0.03580.60650.02990.6472-9.940158.2128-17.1894
907.97490.19972.06763.1497-1.41978.27320.4237-0.57150.17341.3135-2.03060.60490.21530.61221.82010.8865-0.137-0.07460.7190.04520.8997-24.078149.9386-6.4233
915.0467-2.6693-2.15473.2189-1.34234.15930.42220.2014-0.77130.286-0.36780.52720.1376-0.0521-0.08810.5361-0.02120.03240.80350.01280.8288-12.608757.626-4.4931
924.6075-0.4838-0.35194.4307-0.00932.3272-0.7397-1.1714-1.01330.43151.3607-0.0809-1.1547-0.5988-0.14840.80880.3334-0.13291.28140.07790.7857-15.33768.802-3.4954
938.4381.7426-0.32991.62661.16184.3016-0.83790.7771-0.1785-1.06650.5471-0.5161-0.38620.55070.63790.88950.06190.13410.72160.10230.833919.339959.6376-32.132
949.35531.77093.80383.52510.133.60010.4415-0.87430.1624-0.362-0.4632-0.25730.5819-0.36410.00020.5615-0.04140.19740.5712-0.04870.616114.034149.5325-25.3265
956.6716-1.55436.26470.3457-1.44275.87160.58083.3005-2.4821-2.25361.3291-1.1524-0.02791.6515-0.26881.04490.11690.37211.7625-0.22161.171717.002547.9477-41.4579
965.11381.23234.55130.63630.61915.7088-0.00171.23730.5895-0.6687-0.0695-0.9169-1.03551.66180.39040.70590.11020.15040.87670.18690.830624.459856.4321-27.2024
977.39611.81671.24483.51451.18380.32620.33070.4127-1.5577-0.4742-0.2316-0.45450.67950.20940.2090.88320.09030.07050.66370.07180.59834.516346.0408-34.1896
987.8676-0.6674-3.37833.3264-3.71767.51780.3216-2.41431.7732-0.0481.08610.89760.49890.0398-1.33950.43470.0815-0.07940.9595-0.0010.5257-4.032351.5077-28.9329
992.64062.0464-3.62012.1171-1.88066.32271.1026-0.20590.3169-2.501-0.9737-0.80560.52071.83330.53741.09990.08490.09921.0870.00140.58740.02155.6411-25.1038
1002.24570.4054-3.5230.843-1.38156.4316-1.9009-0.1033-0.69030.6183-1.2228-0.41980.33471.06760.14691.0762-0.3835-0.34080.79480.21091.6773-25.88922.8366-23.5894
1012.0842-0.0176-2.36327.314-0.87652.831-1.06040.269-0.4303-0.5848-0.16021.17310.4642-1.251-0.52630.5583-0.0011-0.17781.00190.07341.1323-24.465834.3828-18.629
1028.2694-1.2939-0.04748.20621.00345.22791.2980.23560.7263-0.0629-0.74090.52240.02021.4193-0.30521.1330.15860.14210.63580.15561.1506-24.03342.337-23.2594
1031.91560.06061.35732.2835-0.81043.86530.5869-0.1404-0.8119-1.5373-0.1238-0.33591.375-0.0961-0.41210.6501-0.1822-0.00740.5215-0.06750.8269-8.090122.9988-19.9461
1042.2724-3.28291.58715.216-2.02631.2509-0.4213-1.9036-0.47210.82980.30750.61990.63691.63540.02460.99940.2450.07941.24850.3071.2905-1.292213.9608-5.4698
1054.8856-0.9699-0.00154.8046-0.43846.91140.0562-0.3766-0.2101-0.5147-0.2884-0.1212-0.93351.68480.38010.5811-0.04830.00030.60510.03170.78942.701126.9076-14.8323
1068.4017-2.18931.71666.5033-0.24242.2735-0.68420.5882-1.11461.79030.075-0.7717-1.20640.45810.42590.7460.0274-0.32160.835-0.08220.69040.61332.8424-8.395
1072.8104-0.05440.24680.36520.38040.4031-0.325-0.06090.2345-0.80960.0983-0.7942-0.01370.0474-0.177-0.66721.26050.4104-0.3831-0.51.817213.877226.7589-8.6084
1082.56683.26761.34818.44384.47032.477-0.7777-0.5778-0.20961.7717-0.93351.37920.45340.453-1.34971.2858-0.0780.28940.820.29680.746127.307727.8219-8.6638
1097.85286.8328-6.63237.2514-5.66725.59551.63231.01380.54940.415-0.41631.49850.30321.1666-0.48630.65240.0995-0.31831.504-0.00491.2999-22.629429.7222-6.7701
1107.4971-5.35341.14383.9804-1.60028.2657-0.32460.5402-1.03661.69351.25310.80621.3524-2.144-0.32830.794-0.11660.03990.54830.20061.2638-14.792817.9929-14.5995
1115.4235-0.7692-1.82240.5368-1.40727.01330.441.2069-1.404-0.055-0.4811.05610.8007-0.2216-0.73540.9150.36010.25281.10080.28582.3969-7.940913.5359-11.0057
1120.2506-1.0878-0.01123.438-2.53136.5019-0.3538-0.1437-0.554-0.42190.0289-0.0802-0.3019-0.83070.24320.5161-0.0491-0.20370.82490.01840.781-11.617536.6456-17.1235
1130.7297-0.13380.27522.1158-1.78351.4694-0.7746-1.70730.5168-1.2222-1.4479-0.933-0.8837-0.72721.09521.28280.2851-0.20070.80550.06150.7975-20.293746.2381-31.2083
1141.02311.6555-0.47315.48120.05046.3140.1441.9109-0.9513-1.9085-0.0372-0.1494-0.5081.1337-0.09030.8406-0.1002-0.20960.9296-0.16770.7437-9.754436.8975-29.7197
1156.18860.75063.06697.86781.92634.62330.26531.4655-1.3919-0.7941.6337-0.81861.38150.9067-1.47221.1809-0.2216-0.36671.1686-0.13070.8503-14.846525.9897-31.6392
116-0.0557-0.43870.25415.7144-0.82511.1248-0.77720.18720.32250.18330.3079-0.74630.1025-0.17770.18861.02530.0022-0.08821.12880.05441.657611.4959.61385.692
1173.25261.0849-0.47212.2281-0.94272.0107-0.18270.89110.1303-0.80510.18670.23340.1396-0.26180.0451.11510.08340.14790.7357-0.380.7937-5.276347.5828-34.3376
1182.0303-0.6357-0.62281.7827-1.05472.5236-0.0983-0.5053-0.2620.3370.01680.0477-0.06020.30990.02290.9024-0.0795-0.01060.9664-0.04850.94072.866236.785610.2905
1190.83520.3192.2163.5332-1.44663.5095-0.55831.09081.3939-0.65540.27320.0519-0.27410.2696-0.10891.04720.25250.13620.9686-0.06290.90321.100876.6338-28.3898
1202.34091.2420.63732.3246-0.85070.3292-0.36781.14421.4866-0.3583-0.0097-0.0721-0.28790.35590.23421.4701-0.02280.11051.56940.16231.24799.617380.1854-29.7862
1211.5352-0.5478-1.90583.2148-1.51161.62590.11560.5657-0.38430.310.49251.5233-0.1982-0.6632-0.35650.9231-0.18930.03451.5330.0541.3738-33.602750.5001-1.3573
1221.4274-1.87651.21441.7653-0.94633.4869-0.2975-0.99180.02440.28840.0266-0.5670.04360.66320.3110.952-0.0109-0.08111.40050.12041.231124.072335.80068.5176
1236.07041.12382.65311.88090.02472.1379-0.35541.54021.2483-1.1454-0.07690.2813-0.07560.41680.38791.6430.09420.06381.04840.19431.09674.198558.8429-45.8966
1244.2533-1.7671-1.70543.5309-0.93091.5243-0.1873-0.1465-0.90940.90520.24610.9288-0.5345-0.51710.12450.7593-0.2563-0.15231.5377-0.12841.3554-30.596324.5677-10.7588
1253.31373.2053-0.38112.78710.68734.0701-1.0898-0.2574-1.1421-0.48490.478-1.09350.60230.75080.60251.0829-0.014-0.02960.98030.06421.654918.79610.35435.6154
1262.87-1.44290.4451.771-1.0825.3325-0.0946-0.0560.58141.28910.25991.0636-1.1328-0.1273-0.01741.2477-0.02840.40070.694-0.23591.5159-12.711673.68848.2573
1270.64450.35310.09360.21690.02086.8746-0.4471-1.1393-0.79241.01710.0774-0.6278-1.2180.96050.47931.5450.01610.3410.8518-0.05651.6277-8.673574.347810.35
1285.3306-2.5925-1.78542.35790.45822.42890.27340.18790.39352.15490.47140.43390.5540.91710.0522.0555-0.327-0.10481.55780.06840.716-13.726664.095324.8632
1293.26290.8182-0.66962.7141-0.61250.24520.1680.2228-1.54070.3267-0.8621-1.14611.4226-0.0847-0.00791.2507-0.222-0.00261.32340.09410.9083-8.404962.859418.6322
1304.41331.09291.2232.9432.64962.71561.0017-1.2361-0.47420.0553-0.31770.09211.5608-0.63080.36130.96330.13610.11831.1975-0.05880.6852-12.239360.240511.7523
1310.65030.34180.45235.4489-2.03921.27520.4466-1.0757-0.0561.95971.20850.6044-1.097-0.2269-1.32782.1572-0.6475-0.082.1294-0.26870.7241-1.004152.004138.9666
1323.0848-0.4255-1.18322.72980.73976.3533-0.4362-1.5970.4359-1.9386-0.2556-1.5278-0.4563-3.4004-0.55261.5379-0.3587-0.00192.50110.07770.8824-4.369155.891239.3508
1331.8507-2.15990.79322.8862-0.72181.9888-0.13410.73210.27121.4270.11220.4083-1.0141-0.43250.09141.4890.01650.03871.2572-0.17630.9602-15.982762.784821.2579
1341.66080.11781.03050.41241.08793.12830.2241-1.2061.90060.8928-1.3467-2.0282-0.3870.5617-3.35441.5899-3.0222-1.50760.2945-0.6191.7014-2.237272.063237.275
1353.7426-2.354-1.98743.6553-0.94063.27650.81060.34452.59631.04690.0341-0.9083-4.95411.3926-0.56982.1709-0.01840.18431.5957-0.04770.8116-5.83767.518336.5707
1364.13241.6086-1.87853.26791.21442.24430.6911-1.0525-1.2411-0.66690.291.19711.5437-1.12790.09491.1654-0.1836-2.18412.6066-0.48190.34793.318153.117431.553
1373.13280.32160.44621.13590.11770.17541.5608-1.58391.83321.3599-1.60420.43340.0657-0.2798-0.87563.3542-0.87370.9210.5005-0.72771.67423.586567.825720.9405
1382.72110.645-1.20013.6680.89684.5153-0.8670.0760.10850.1146-0.2859-0.21160.4376-0.19260.31541.3506-0.06350.18351.70620.01730.95155.61157.761518.591
1395.51743.74491.3553.8794-1.05813.4452-1.12785.12291.877-2.68221.6568-1.34190.40180.6450.63721.9559-0.3249-0.51361.49260.5181.3621-13.384725.3502-46.0756
1400.09890.58520.1787.49994.3273.01410.0332-0.6578-0.4184-0.8313-0.7642-0.8623-0.2892-1.22120.81241.504-0.5153-0.59841.19580.26221.063-2.298816.7266-33.7885
1411.9996-5.3109-9.17544.75446.26389.0610.1992-3.4408-1.01582.27610.7649-0.64680.73141.2321-0.06682.29740.09330.31661.1950.56081.5074-4.771221.2637-44.2873
1428.2974-1.32623.69250.98821.07665.15450.41320.4235-1.90461.1365-1.31611.69590.4446-0.2066-1.60132.8283-0.6993-0.25081.011-0.51711.3663-7.859116.7638-54.3604
1436.80945.14612.02335.5989-2.11347.8776-0.20781.4629-0.0304-1.48211.7517-0.61120.04831.488-0.6563.30270.1718-0.14271.32440.18140.5662-1.148729.4012-57.1994
1444.70063.4843-2.02723.0329-2.07365.6623-0.8165-2.4432-0.1617-1.3926-0.6511-0.026-1.69791.74730.74162.1725-0.1681-0.11051.5492-0.2561.1571-3.227332.7579-45.6744
1452.7735-2.6697-2.79197.4303-0.73585.24020.69811.925-1.4976-2.51251.30930.35670.87481.3344-0.91022.0536-0.1725-0.58091.7925-0.40410.8099-3.579734.9937-53.1372
146-0.0061-0.20990.01553.72460.7740.105-1.07890.96960.546-2.51880.0842-0.88440.0872-0.163-3.46472.44890.1530.20941.3732-1.1340.07834.595525.2142-62.4041
1478.22712.9587-0.36861.0341-0.11720.01110.0248-1.71293.76170.0881-0.92781.1221-0.4265-0.1856-0.75563.6120.65390.13691.0118-0.49051.79269.967123.0366-46.5353
1483.5566-3.0284-2.15444.73465.63739.05051.0747-0.1087-0.4551.9551-0.32611.87571.28622.7931-0.14342.426-0.0980.41011.3868-0.14241.589212.41634.1711-44.7961
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain 'A' and (resid 38 through 44 )A38 - 44
2X-RAY DIFFRACTION2chain 'A' and (resid 45 through 55 )A45 - 55
3X-RAY DIFFRACTION3chain 'A' and (resid 56 through 63 )A56 - 63
4X-RAY DIFFRACTION4chain 'A' and (resid 64 through 77 )A64 - 77
5X-RAY DIFFRACTION5chain 'A' and (resid 78 through 85 )A78 - 85
6X-RAY DIFFRACTION6chain 'A' and (resid 86 through 113 )A86 - 113
7X-RAY DIFFRACTION7chain 'A' and (resid 114 through 120 )A114 - 120
8X-RAY DIFFRACTION8chain 'A' and (resid 121 through 134 )A121 - 134
9X-RAY DIFFRACTION9chain 'B' and (resid 18 through 30 )B18 - 30
10X-RAY DIFFRACTION10chain 'B' and (resid 31 through 49 )B31 - 49
11X-RAY DIFFRACTION11chain 'B' and (resid 50 through 82 )B50 - 82
12X-RAY DIFFRACTION12chain 'B' and (resid 83 through 93 )B83 - 93
13X-RAY DIFFRACTION13chain 'B' and (resid 94 through 101 )B94 - 101
14X-RAY DIFFRACTION14chain 'C' and (resid 15 through 26 )C15 - 26
15X-RAY DIFFRACTION15chain 'C' and (resid 27 through 35 )C27 - 35
16X-RAY DIFFRACTION16chain 'C' and (resid 36 through 72 )C36 - 72
17X-RAY DIFFRACTION17chain 'C' and (resid 73 through 118 )C73 - 118
18X-RAY DIFFRACTION18chain 'D' and (resid 32 through 48 )D32 - 48
19X-RAY DIFFRACTION19chain 'D' and (resid 49 through 90 )D49 - 90
20X-RAY DIFFRACTION20chain 'D' and (resid 91 through 124 )D91 - 124
21X-RAY DIFFRACTION21chain 'E' and (resid 40 through 63 )E40 - 63
22X-RAY DIFFRACTION22chain 'E' and (resid 64 through 85 )E64 - 85
23X-RAY DIFFRACTION23chain 'E' and (resid 86 through 120 )E86 - 120
24X-RAY DIFFRACTION24chain 'E' and (resid 121 through 134 )E121 - 134
25X-RAY DIFFRACTION25chain 'F' and (resid 18 through 24 )F18 - 24
26X-RAY DIFFRACTION26chain 'F' and (resid 25 through 40 )F25 - 40
27X-RAY DIFFRACTION27chain 'F' and (resid 41 through 75 )F41 - 75
28X-RAY DIFFRACTION28chain 'F' and (resid 76 through 93 )F76 - 93
29X-RAY DIFFRACTION29chain 'F' and (resid 94 through 100 )F94 - 100
30X-RAY DIFFRACTION30chain 'G' and (resid 12 through 16 )G12 - 16
31X-RAY DIFFRACTION31chain 'G' and (resid 17 through 26 )G17 - 26
32X-RAY DIFFRACTION32chain 'G' and (resid 27 through 35 )G27 - 35
33X-RAY DIFFRACTION33chain 'G' and (resid 36 through 46 )G36 - 46
34X-RAY DIFFRACTION34chain 'G' and (resid 47 through 72 )G47 - 72
35X-RAY DIFFRACTION35chain 'G' and (resid 73 through 79 )G73 - 79
36X-RAY DIFFRACTION36chain 'G' and (resid 80 through 96 )G80 - 96
37X-RAY DIFFRACTION37chain 'G' and (resid 97 through 111 )G97 - 111
38X-RAY DIFFRACTION38chain 'G' and (resid 112 through 118 )G112 - 118
39X-RAY DIFFRACTION39chain 'H' and (resid 32 through 37 )H32 - 37
40X-RAY DIFFRACTION40chain 'H' and (resid 38 through 48 )H38 - 48
41X-RAY DIFFRACTION41chain 'H' and (resid 49 through 55 )H49 - 55
42X-RAY DIFFRACTION42chain 'H' and (resid 56 through 83 )H56 - 83
43X-RAY DIFFRACTION43chain 'H' and (resid 84 through 90 )H84 - 90
44X-RAY DIFFRACTION44chain 'H' and (resid 91 through 103 )H91 - 103
45X-RAY DIFFRACTION45chain 'H' and (resid 104 through 124 )H104 - 124
46X-RAY DIFFRACTION46chain 'I' and (resid 2 through 91 )I2 - 91
47X-RAY DIFFRACTION47chain 'I' and (resid 92 through 147 )I92 - 147
48X-RAY DIFFRACTION48chain 'J' and (resid 1 through 30 )J1 - 30
49X-RAY DIFFRACTION49chain 'J' and (resid 31 through 90 )J31 - 90
50X-RAY DIFFRACTION50chain 'J' and (resid 91 through 120 )J91 - 120
51X-RAY DIFFRACTION51chain 'J' and (resid 121 through 147 )J121 - 147
52X-RAY DIFFRACTION52chain 'K' and (resid 2 through 21 )K2 - 21
53X-RAY DIFFRACTION53chain 'K' and (resid 22 through 65 )K22 - 65
54X-RAY DIFFRACTION54chain 'K' and (resid 66 through 149 )K66 - 149
55X-RAY DIFFRACTION55chain 'K' and (resid 150 through 160 )K150 - 160
56X-RAY DIFFRACTION56chain 'K' and (resid 161 through 177 )K161 - 177
57X-RAY DIFFRACTION57chain 'K' and (resid 178 through 213 )K178 - 213
58X-RAY DIFFRACTION58chain 'L' and (resid 2 through 16 )L2 - 16
59X-RAY DIFFRACTION59chain 'L' and (resid 17 through 37 )L17 - 37
60X-RAY DIFFRACTION60chain 'L' and (resid 38 through 58 )L38 - 58
61X-RAY DIFFRACTION61chain 'L' and (resid 59 through 89 )L59 - 89
62X-RAY DIFFRACTION62chain 'L' and (resid 90 through 116 )L90 - 116
63X-RAY DIFFRACTION63chain 'L' and (resid 117 through 126 )L117 - 126
64X-RAY DIFFRACTION64chain 'L' and (resid 127 through 142 )L127 - 142
65X-RAY DIFFRACTION65chain 'L' and (resid 143 through 160 )L143 - 160
66X-RAY DIFFRACTION66chain 'L' and (resid 161 through 177 )L161 - 177
67X-RAY DIFFRACTION67chain 'L' and (resid 178 through 188 )L178 - 188
68X-RAY DIFFRACTION68chain 'L' and (resid 189 through 198 )L189 - 198
69X-RAY DIFFRACTION69chain 'L' and (resid 199 through 213 )L199 - 213
70X-RAY DIFFRACTION70chain 'M' and (resid 37 through 44 )M37 - 44
71X-RAY DIFFRACTION71chain 'M' and (resid 45 through 55 )M45 - 55
72X-RAY DIFFRACTION72chain 'M' and (resid 56 through 85 )M56 - 85
73X-RAY DIFFRACTION73chain 'M' and (resid 86 through 113 )M86 - 113
74X-RAY DIFFRACTION74chain 'M' and (resid 114 through 120 )M114 - 120
75X-RAY DIFFRACTION75chain 'M' and (resid 121 through 134 )M121 - 134
76X-RAY DIFFRACTION76chain 'N' and (resid 18 through 24 )N18 - 24
77X-RAY DIFFRACTION77chain 'N' and (resid 25 through 40 )N25 - 40
78X-RAY DIFFRACTION78chain 'N' and (resid 41 through 82 )N41 - 82
79X-RAY DIFFRACTION79chain 'N' and (resid 83 through 101 )N83 - 101
80X-RAY DIFFRACTION80chain 'O' and (resid 12 through 26 )O12 - 26
81X-RAY DIFFRACTION81chain 'O' and (resid 27 through 35 )O27 - 35
82X-RAY DIFFRACTION82chain 'O' and (resid 36 through 46 )O36 - 46
83X-RAY DIFFRACTION83chain 'O' and (resid 47 through 72 )O47 - 72
84X-RAY DIFFRACTION84chain 'O' and (resid 73 through 79 )O73 - 79
85X-RAY DIFFRACTION85chain 'O' and (resid 80 through 89 )O80 - 89
86X-RAY DIFFRACTION86chain 'O' and (resid 90 through 111 )O90 - 111
87X-RAY DIFFRACTION87chain 'O' and (resid 112 through 118 )O112 - 118
88X-RAY DIFFRACTION88chain 'P' and (resid 32 through 55 )P32 - 55
89X-RAY DIFFRACTION89chain 'P' and (resid 56 through 83 )P56 - 83
90X-RAY DIFFRACTION90chain 'P' and (resid 84 through 90 )P84 - 90
91X-RAY DIFFRACTION91chain 'P' and (resid 91 through 103 )P91 - 103
92X-RAY DIFFRACTION92chain 'P' and (resid 104 through 124 )P104 - 124
93X-RAY DIFFRACTION93chain 'Q' and (resid 40 through 77 )Q40 - 77
94X-RAY DIFFRACTION94chain 'Q' and (resid 78 through 134 )Q78 - 134
95X-RAY DIFFRACTION95chain 'R' and (resid 22 through 30 )R22 - 30
96X-RAY DIFFRACTION96chain 'R' and (resid 31 through 48 )R31 - 48
97X-RAY DIFFRACTION97chain 'R' and (resid 49 through 82 )R49 - 82
98X-RAY DIFFRACTION98chain 'R' and (resid 83 through 92 )R83 - 92
99X-RAY DIFFRACTION99chain 'R' and (resid 93 through 101 )R93 - 101
100X-RAY DIFFRACTION100chain 'S' and (resid 12 through 26 )S12 - 26
101X-RAY DIFFRACTION101chain 'S' and (resid 27 through 35 )S27 - 35
102X-RAY DIFFRACTION102chain 'S' and (resid 36 through 46 )S36 - 46
103X-RAY DIFFRACTION103chain 'S' and (resid 47 through 72 )S47 - 72
104X-RAY DIFFRACTION104chain 'S' and (resid 73 through 79 )S73 - 79
105X-RAY DIFFRACTION105chain 'S' and (resid 80 through 96 )S80 - 96
106X-RAY DIFFRACTION106chain 'S' and (resid 97 through 106 )S97 - 106
107X-RAY DIFFRACTION107chain 'S' and (resid 107 through 111 )S107 - 111
108X-RAY DIFFRACTION108chain 'S' and (resid 112 through 118 )S112 - 118
109X-RAY DIFFRACTION109chain 'T' and (resid 32 through 37 )T32 - 37
110X-RAY DIFFRACTION110chain 'T' and (resid 38 through 48 )T38 - 48
111X-RAY DIFFRACTION111chain 'T' and (resid 49 through 55 )T49 - 55
112X-RAY DIFFRACTION112chain 'T' and (resid 56 through 83 )T56 - 83
113X-RAY DIFFRACTION113chain 'T' and (resid 84 through 90 )T84 - 90
114X-RAY DIFFRACTION114chain 'T' and (resid 91 through 104 )T91 - 104
115X-RAY DIFFRACTION115chain 'T' and (resid 105 through 124 )T105 - 124
116X-RAY DIFFRACTION116chain 'U' and (resid 2 through 21 )U2 - 21
117X-RAY DIFFRACTION117chain 'U' and (resid 22 through 71 )U22 - 71
118X-RAY DIFFRACTION118chain 'U' and (resid 72 through 111 )U72 - 111
119X-RAY DIFFRACTION119chain 'U' and (resid 112 through 147 )U112 - 147
120X-RAY DIFFRACTION120chain 'V' and (resid 1 through 30 )V1 - 30
121X-RAY DIFFRACTION121chain 'V' and (resid 31 through 50 )V31 - 50
122X-RAY DIFFRACTION122chain 'V' and (resid 51 through 80 )V51 - 80
123X-RAY DIFFRACTION123chain 'V' and (resid 81 through 110 )V81 - 110
124X-RAY DIFFRACTION124chain 'V' and (resid 111 through 130 )V111 - 130
125X-RAY DIFFRACTION125chain 'V' and (resid 131 through 147 )V131 - 147
126X-RAY DIFFRACTION126chain 'W' and (resid 2 through 30 )W2 - 30
127X-RAY DIFFRACTION127chain 'W' and (resid 31 through 47 )W31 - 47
128X-RAY DIFFRACTION128chain 'W' and (resid 48 through 65 )W48 - 65
129X-RAY DIFFRACTION129chain 'W' and (resid 66 through 76 )W66 - 76
130X-RAY DIFFRACTION130chain 'W' and (resid 77 through 89 )W77 - 89
131X-RAY DIFFRACTION131chain 'W' and (resid 90 through 116 )W90 - 116
132X-RAY DIFFRACTION132chain 'W' and (resid 117 through 137 )W117 - 137
133X-RAY DIFFRACTION133chain 'W' and (resid 138 through 149 )W138 - 149
134X-RAY DIFFRACTION134chain 'W' and (resid 150 through 161 )W150 - 161
135X-RAY DIFFRACTION135chain 'W' and (resid 162 through 176 )W162 - 176
136X-RAY DIFFRACTION136chain 'W' and (resid 177 through 188 )W177 - 188
137X-RAY DIFFRACTION137chain 'W' and (resid 189 through 200 )W189 - 200
138X-RAY DIFFRACTION138chain 'W' and (resid 201 through 212 )W201 - 212
139X-RAY DIFFRACTION139chain 'X' and (resid 2 through 16 )X2 - 16
140X-RAY DIFFRACTION140chain 'X' and (resid 17 through 37 )X17 - 37
141X-RAY DIFFRACTION141chain 'X' and (resid 38 through 42 )X38 - 42
142X-RAY DIFFRACTION142chain 'X' and (resid 45 through 49 )X45 - 49
143X-RAY DIFFRACTION143chain 'X' and (resid 50 through 68 )X50 - 68
144X-RAY DIFFRACTION144chain 'X' and (resid 69 through 89 )X69 - 89
145X-RAY DIFFRACTION145chain 'X' and (resid 90 through 145 )X90 - 145
146X-RAY DIFFRACTION146chain 'X' and (resid 146 through 189 )X146 - 189
147X-RAY DIFFRACTION147chain 'X' and (resid 190 through 200 )X190 - 200
148X-RAY DIFFRACTION148chain 'X' and (resid 201 through 211 )X201 - 211

+
About Yorodumi

-
News

-
Feb 9, 2022. New format data for meta-information of EMDB entries

New format data for meta-information of EMDB entries

  • Version 3 of the EMDB header file is now the official format.
  • The previous official version 1.9 will be removed from the archive.

Related info.:EMDB header

External links:wwPDB to switch to version 3 of the EMDB data model

-
Aug 12, 2020. Covid-19 info

Covid-19 info

URL: https://pdbj.org/emnavi/covid19.php

New page: Covid-19 featured information page in EM Navigator.

Related info.:Covid-19 info / Mar 5, 2020. Novel coronavirus structure data

+
Mar 5, 2020. Novel coronavirus structure data

Novel coronavirus structure data

Related info.:Yorodumi Speices / Aug 12, 2020. Covid-19 info

External links:COVID-19 featured content - PDBj / Molecule of the Month (242)：Coronavirus Proteases

+
Jan 31, 2019. EMDB accession codes are about to change! (news from PDBe EMDB page)

EMDB accession codes are about to change! (news from PDBe EMDB page)

  • The allocation of 4 digits for EMDB accession codes will soon come to an end. Whilst these codes will remain in use, new EMDB accession codes will include an additional digit and will expand incrementally as the available range of codes is exhausted. The current 4-digit format prefixed with “EMD-” (i.e. EMD-XXXX) will advance to a 5-digit format (i.e. EMD-XXXXX), and so on. It is currently estimated that the 4-digit codes will be depleted around Spring 2019, at which point the 5-digit format will come into force.
  • The EM Navigator/Yorodumi systems omit the EMD- prefix.

Related info.:Q: What is EMD? / ID/Accession-code notation in Yorodumi/EM Navigator

External links:EMDB Accession Codes are Changing Soon! / Contact to PDBj

+
Jul 12, 2017. Major update of PDB

Major update of PDB

  • wwPDB released updated PDB data conforming to the new PDBx/mmCIF dictionary.
  • This is a major update changing the version number from 4 to 5, and with Remediation, in which all the entries are updated.
  • In this update, many items about electron microscopy experimental information are reorganized (e.g. em_software).
  • Now, EM Navigator and Yorodumi are based on the updated data.

External links:wwPDB Remediation / Enriched Model Files Conforming to OneDep Data Standards Now Available in the PDB FTP Archive

-
Yorodumi

Thousand views of thousand structures

  • Yorodumi is a browser for structure data from EMDB, PDB, SASBDB, etc.
  • This page is also the successor to EM Navigator detail page, and also detail information page/front-end page for Omokage search.
  • The word "yorodu" (or yorozu) is an old Japanese word meaning "ten thousand". "mi" (miru) is to see.

Related info.:EMDB / PDB / SASBDB / Comparison of 3 databanks / Yorodumi Search / Aug 31, 2016. New EM Navigator & Yorodumi / Yorodumi Papers / Jmol/JSmol / Function and homology information / Changes in new EM Navigator and Yorodumi

Read more