Entry | Database: PDB / ID: 6of0 |
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Title | Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae |
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Components | HTH-type transcriptional regulator MtrR |
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Keywords | DNA BINDING PROTEIN / TetR family / Helix-turn-helix (HTH) / transcription regulator |
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Function / homology | Function and homology information
Transcription regulator MAATS, C-terminal / MAATS-type transcriptional repressor, C-terminal region / DNA-binding HTH domain, TetR-type, conserved site / TetR-type HTH domain signature. / Tetracycline Repressor, domain 2 / Tetracyclin repressor-like, C-terminal domain superfamily / Tetracycline Repressor; domain 2 / Bacterial regulatory proteins, tetR family / DNA-binding HTH domain, TetR-type / TetR-type HTH domain profile. ...Transcription regulator MAATS, C-terminal / MAATS-type transcriptional repressor, C-terminal region / DNA-binding HTH domain, TetR-type, conserved site / TetR-type HTH domain signature. / Tetracycline Repressor, domain 2 / Tetracyclin repressor-like, C-terminal domain superfamily / Tetracycline Repressor; domain 2 / Bacterial regulatory proteins, tetR family / DNA-binding HTH domain, TetR-type / TetR-type HTH domain profile. / Homeobox-like domain superfamily / Orthogonal Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Neisseria gonorrhoeae (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2 Å |
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Authors | Beggs, G.A. / Kumaraswami, M. / Shafer, W. / Brennan, R.G. |
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Funding support | United States, 4items Organization | Grant number | Country |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R05 AI048593-09 | United States | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | 1R01AI109096-01A1 | United States | National Science Foundation (NSF, United States) | DGE-1644868 | United States | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R37 AI021150-32 | United States |
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Citation | Journal: J.Bacteriol. / Year: 2019 Title: Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae . Authors: Beggs, G.A. / Zalucki, Y.M. / Brown, N.G. / Rastegari, S. / Phillips, R.K. / Palzkill, T. / Shafer, W.M. / Kumaraswami, M. / Brennan, R.G. |
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History | Deposition | Mar 28, 2019 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jul 31, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 2, 2019 | Group: Data collection / Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.title ..._citation.journal_volume / _citation.title / _citation_author.identifier_ORCID / _citation_author.name |
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Revision 1.2 | Nov 27, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.3 | Oct 7, 2020 | Group: Database references / Category: citation / Item: _citation.title |
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Revision 1.4 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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