登録情報 データベース : PDB / ID : 6nhw 構造の表示 ダウンロードとリンクタイトル Structure of the transmembrane domain of the Death Receptor 5 - Dimer of Trimer 要素Tumor necrosis factor receptor superfamily member 10B 詳細 キーワード IMMUNE SYSTEM / Death Receptor 5 / transmembrane helix oligomer / transmembrane helix mediated signaling / preligand autoinhibition機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
TRAIL receptor activity / TRAIL binding / TRAIL signaling / TRAIL-activated apoptotic signaling pathway / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 / Caspase activation via Death Receptors in the presence of ligand / activation of NF-kappaB-inducing kinase activity / defense response to tumor cell ... TRAIL receptor activity / TRAIL binding / TRAIL signaling / TRAIL-activated apoptotic signaling pathway / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 / Caspase activation via Death Receptors in the presence of ligand / activation of NF-kappaB-inducing kinase activity / defense response to tumor cell / TP53 Regulates Transcription of Death Receptors and Ligands / RIPK1-mediated regulated necrosis / extrinsic apoptotic signaling pathway via death domain receptors / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / response to endoplasmic reticulum stress / Cell surface interactions at the vascular wall / cellular response to mechanical stimulus / signaling receptor activity / regulation of apoptotic process / positive regulation of canonical NF-kappaB signal transduction / cell surface receptor signaling pathway / positive regulation of apoptotic process / apoptotic process / cell surface / plasma membrane 類似検索 - 分子機能 Tumour necrosis factor receptor 10 / Tumor necrosis factor receptor 10, N-terminal / Tumour necrosis factor receptor 10A/B, death domain / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). ... Tumour necrosis factor receptor 10 / Tumor necrosis factor receptor 10, N-terminal / Tumour necrosis factor receptor 10A/B, death domain / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Death-like domain superfamily 類似検索 - ドメイン・相同性 Tumor necrosis factor receptor superfamily member 10B 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 溶液NMR / simulated annealing 詳細データ登録者 Chou, J.J. / Pan, L. / Fu, Q. / Zhao, L. / Chen, W. / Piai, A. / Fu, T. / Wu, H. 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM116898 米国
引用ジャーナル : Cell / 年 : 2019タイトル : Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling.著者 : Pan, L. / Fu, T.M. / Zhao, W. / Zhao, L. / Chen, W. / Qiu, C. / Liu, W. / Liu, Z. / Piai, A. / Fu, Q. / Chen, S. / Wu, H. / Chou, J.J. 履歴 登録 2018年12月24日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2019年2月27日 Provider : repository / タイプ : Initial release改定 1.1 2019年3月20日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.journal_abbrev / _citation.journal_id_CSD ... _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2020年1月1日 Group : Author supporting evidence / Data collection / カテゴリ : pdbx_audit_support / pdbx_nmr_spectrometerItem : _pdbx_audit_support.funding_organization / _pdbx_nmr_spectrometer.model改定 1.3 2023年6月14日 Group : Database references / Other / カテゴリ : database_2 / pdbx_database_statusItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data改定 1.4 2024年5月15日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2 / Item : _database_2.pdbx_DOI
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