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基本情報
登録情報 | データベース: PDB / ID: 6mie | ||||||
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タイトル | Solution NMR structure of the KCNQ1 voltage-sensing domain | ||||||
![]() | Potassium voltage-gated channel subfamily KQT member 1 | ||||||
![]() | MEMBRANE PROTEIN / ion channel / KCNQ1 / Kv7.1 / voltage sensor / potassium channel | ||||||
機能・相同性 | ![]() gastrin-induced gastric acid secretion / corticosterone secretion / voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization / basolateral part of cell / lumenal side of membrane / negative regulation of voltage-gated potassium channel activity / rhythmic behavior / regulation of gastric acid secretion / stomach development / iodide transport ...gastrin-induced gastric acid secretion / corticosterone secretion / voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization / basolateral part of cell / lumenal side of membrane / negative regulation of voltage-gated potassium channel activity / rhythmic behavior / regulation of gastric acid secretion / stomach development / iodide transport / voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization / Phase 3 - rapid repolarisation / membrane repolarization during atrial cardiac muscle cell action potential / membrane repolarization during action potential / regulation of atrial cardiac muscle cell membrane repolarization / Phase 2 - plateau phase / intracellular chloride ion homeostasis / membrane repolarization during ventricular cardiac muscle cell action potential / membrane repolarization during cardiac muscle cell action potential / negative regulation of delayed rectifier potassium channel activity / renal sodium ion absorption / detection of mechanical stimulus involved in sensory perception of sound / potassium ion export across plasma membrane / atrial cardiac muscle cell action potential / voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization / auditory receptor cell development / regulation of membrane repolarization / protein phosphatase 1 binding / delayed rectifier potassium channel activity / ventricular cardiac muscle cell action potential / positive regulation of potassium ion transmembrane transport / Voltage gated Potassium channels / potassium ion homeostasis / non-motile cilium assembly / regulation of ventricular cardiac muscle cell membrane repolarization / cardiac muscle cell contraction / outward rectifier potassium channel activity / intestinal absorption / inner ear morphogenesis / adrenergic receptor signaling pathway / cochlea development / regulation of heart contraction / renal absorption / ciliary base / protein kinase A regulatory subunit binding / protein kinase A catalytic subunit binding / potassium ion import across plasma membrane / social behavior / inner ear development / regulation of heart rate by cardiac conduction / action potential / voltage-gated potassium channel activity / monoatomic ion channel complex / positive regulation of heart rate / transport vesicle / cardiac muscle contraction / cellular response to cAMP / voltage-gated potassium channel complex / phosphatidylinositol-4,5-bisphosphate binding / cellular response to epinephrine stimulus / potassium ion transmembrane transport / positive regulation of cardiac muscle contraction / cytoplasmic vesicle membrane / erythrocyte differentiation / response to insulin / sensory perception of sound / regulation of blood pressure / glucose metabolic process / late endosome / cellular response to xenobiotic stimulus / heart development / scaffold protein binding / basolateral plasma membrane / transmembrane transporter binding / early endosome / lysosome / calmodulin binding / neuron projection / apical plasma membrane / membrane raft / neuronal cell body / endoplasmic reticulum / membrane / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | 溶液NMR / molecular dynamics | ||||||
![]() | Taylor, K.C. / Kuenze, G. / Smith, J.A. / Meiler, J. / McFeeters, R.L. / Sanders, C.R. | ||||||
資金援助 | ![]()
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![]() | ![]() タイトル: Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state. 著者: Taylor, K.C. / Kang, P.W. / Hou, P. / Yang, N.D. / Kuenze, G. / Smith, J.A. / Shi, J. / Huang, H. / White, K.M. / Peng, D. / George, A.L. / Meiler, J. / McFeeters, R.L. / Cui, J. / Sanders, C.R. | ||||||
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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PDBx/mmCIF形式 | ![]() | 486.1 KB | 表示 | ![]() |
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PDB形式 | ![]() | 411.3 KB | 表示 | ![]() |
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-検証レポート
文書・要旨 | ![]() | 411.7 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 465.7 KB | 表示 | |
XML形式データ | ![]() | 30.9 KB | 表示 | |
CIF形式データ | ![]() | 42.4 KB | 表示 | |
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NMR アンサンブル |
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要素
#1: タンパク質 | 分子量: 18184.631 Da / 分子数: 1 / 断片: UNP residues 100-249 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() ![]() |
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-実験情報
-実験
実験 | 手法: 溶液NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR実験 |
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