Entry Database : PDB / ID : 6ln4 Structure visualization Downloads & linksTitle Estrogen-related receptor beta(ERR2) in complex with PGC1a-2a Components10-mer from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Steroid hormone receptor ERR2 DetailsKeywords TRANSCRIPTION / ERR2 / Transcription factor / BPAFunction / homology Function and homology informationFunction Domain/homology Component
cell dedifferentiation / regulation of stem cell division / Regulation of MITF-M dependent genes involved in metabolism / positive regulation of fatty acid oxidation / stem cell division / negative regulation of stem cell differentiation / photoreceptor cell maintenance / response to muscle activity / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / cellular respiration ... cell dedifferentiation / regulation of stem cell division / Regulation of MITF-M dependent genes involved in metabolism / positive regulation of fatty acid oxidation / stem cell division / negative regulation of stem cell differentiation / photoreceptor cell maintenance / response to muscle activity / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / cellular respiration / lncRNA binding / nuclear steroid receptor activity / temperature homeostasis / stem cell population maintenance / positive regulation of stem cell population maintenance / response to starvation / RNA polymerase II complex binding / intracellular glucose homeostasis / fatty acid oxidation / response to dietary excess / inner ear development / cis-regulatory region sequence-specific DNA binding / estrogen response element binding / adipose tissue development / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / brown fat cell differentiation / Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 / nuclear receptor-mediated steroid hormone signaling pathway / energy homeostasis / condensed chromosome / positive regulation of gluconeogenesis / digestion / steroid binding / respiratory electron transport chain / RNA splicing / SUMOylation of transcription cofactors / nuclear receptor coactivator activity / mitochondrion organization / gluconeogenesis / nuclear receptor binding / transcription initiation at RNA polymerase II promoter / negative regulation of smooth muscle cell proliferation / transcription coregulator activity / circadian regulation of gene expression / Heme signaling / Transcriptional activation of mitochondrial biogenesis / regulation of circadian rhythm / PPARA activates gene expression / PML body / chromatin DNA binding / positive regulation of DNA-binding transcription factor activity / Transcriptional regulation of white adipocyte differentiation / Nuclear Receptor transcription pathway / mRNA processing / Regulation of RUNX2 expression and activity / nuclear receptor activity / sequence-specific double-stranded DNA binding / Circadian Clock / positive regulation of cold-induced thermogenesis / cellular response to oxidative stress / protein-containing complex assembly / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor binding / neuron apoptotic process / negative regulation of neuron apoptotic process / RNA polymerase II-specific DNA-binding transcription factor binding / sequence-specific DNA binding / cell population proliferation / transcription coactivator activity / protein stabilization / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / ubiquitin protein ligase binding / regulation of DNA-templated transcription / positive regulation of gene expression / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / zinc ion binding / nucleoplasm / nucleus / cytosol / cytoplasm Similarity search - Function PGC-1alpha, RNA recognition motif / PGC-1 / Oestrogen-related receptor / Estrogen receptor/oestrogen-related receptor / : / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily ... PGC-1alpha, RNA recognition motif / PGC-1 / Oestrogen-related receptor / Estrogen receptor/oestrogen-related receptor / : / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Nucleotide-binding alpha-beta plait domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.61 Å DetailsAuthors Yao, B.Q. / Li, Y. Funding support China, 1items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China (NSFC) 31770814 China
CitationJournal : J.Mol.Biol. / Year : 2020Title : Structural Insights into the Specificity of Ligand Binding and Coactivator Assembly by Estrogen-Related Receptor beta.Authors : Yao, B. / Zhang, S. / Wei, Y. / Tian, S. / Lu, Z. / Jin, L. / He, Y. / Xie, W. / Li, Y. History Deposition Dec 28, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Oct 7, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Oct 14, 2020 Group : Derived calculationsCategory : pdbx_struct_assembly / pdbx_struct_assembly_gen ... pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop / pdbx_struct_oper_list Revision 1.2 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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