- PDB-6kzc: crystal structure of TRKc in complex with 3-(imidazo[1,2-a]pyrazi... -
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Basic information
Entry
Database: PDB / ID: 6kzc
Title
crystal structure of TRKc in complex with 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-N-(3-((4- methylpiperazin-1-yl)methyl)-5- (trifluoromethyl)phenyl)benzamide
Components
NT-3 growth factor receptor
Keywords
TRANSFERASE / TRKc
Function / homology
Function and homology information
NTF3 activates NTRK3 signaling / Activated NTRK3 signals through PLCG1 / Signaling by NTRK3 (TRKC) / Receptor-type tyrosine-protein phosphatases / NTRK3 as a dependence receptor / neurotrophin receptor activity / neurotrophin binding / Activated NTRK3 signals through PI3K / activation of GTPase activity / positive regulation of positive chemotaxis ...NTF3 activates NTRK3 signaling / Activated NTRK3 signals through PLCG1 / Signaling by NTRK3 (TRKC) / Receptor-type tyrosine-protein phosphatases / NTRK3 as a dependence receptor / neurotrophin receptor activity / neurotrophin binding / Activated NTRK3 signals through PI3K / activation of GTPase activity / positive regulation of positive chemotaxis / Activated NTRK3 signals through RAS / cell surface receptor protein tyrosine kinase signaling pathway / transmembrane receptor protein tyrosine kinase activity / activation of protein kinase B activity / negative regulation of protein phosphorylation / cellular response to nerve growth factor stimulus / positive regulation of MAP kinase activity / receptor protein-tyrosine kinase / positive regulation of neuron projection development / Constitutive Signaling by Aberrant PI3K in Cancer / p53 binding / PIP3 activates AKT signaling / positive regulation of peptidyl-serine phosphorylation / heart development / nervous system development / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell differentiation / receptor complex / positive regulation of cell migration / positive regulation of protein phosphorylation / axon / positive regulation of cell population proliferation / positive regulation of gene expression / ATP binding / plasma membrane Similarity search - Function
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