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-Structure paper
Title | Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 179, Page 470-482, Year 2019 |
Publish date | Sep 23, 2019 (structure data deposition date) |
Authors | Cui, S. / Wang, Y. / Tang, X. / Ren, X. / Zhang, L. / Xu, Y. / Zhang, Z. / Zhang, Z.M. / Lu, X. / Ding, K. |
External links | Eur. J. Med. Chem. / PubMed:31271959 |
Methods | X-ray diffraction |
Resolution | 1.708 - 2 Å |
Structure data | PDB-6kzc: PDB-6kzd: |
Chemicals | ChemComp-DZC: ChemComp-HOH: ChemComp-DZ6: ChemComp-PO4: |
Source |
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Keywords | TRANSFERASE / TRKc |