Entry Database : PDB / ID : 6kkg Structure visualization Downloads & linksTitle Crystal structure of MAGI2-Dendrin complex ComponentsMembrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 Peptide from Dendrin DetailsKeywords CELL ADHESION / MAGI2 / Dendrin / Complex structure / Slit diaphragmFunction / homology Function and homology informationFunction Domain/homology Component
structural constituent of postsynaptic specialization / extrinsic component of postsynaptic membrane / type II activin receptor binding / neuroligin clustering involved in postsynaptic membrane assembly / podocyte development / positive regulation of synaptic vesicle clustering / slit diaphragm / beta-1 adrenergic receptor binding / structural constituent of postsynaptic density / activin receptor binding ... structural constituent of postsynaptic specialization / extrinsic component of postsynaptic membrane / type II activin receptor binding / neuroligin clustering involved in postsynaptic membrane assembly / podocyte development / positive regulation of synaptic vesicle clustering / slit diaphragm / beta-1 adrenergic receptor binding / structural constituent of postsynaptic density / activin receptor binding / nerve growth factor signaling pathway / clathrin-dependent endocytosis / SMAD protein signal transduction / negative regulation of activin receptor signaling pathway / dendritic spine membrane / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / regulation of synaptic membrane adhesion / ciliary base / receptor clustering / SMAD binding / kinesin binding / positive regulation of phosphoprotein phosphatase activity / positive regulation of receptor internalization / photoreceptor outer segment / GABA-ergic synapse / bicellular tight junction / phosphatase binding / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / centriole / photoreceptor inner segment / negative regulation of cell migration / cellular response to nerve growth factor stimulus / positive regulation of neuron projection development / cell-cell junction / signaling receptor complex adaptor activity / late endosome / postsynaptic membrane / perikaryon / postsynaptic density / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of cell population proliferation / centrosome / glutamatergic synapse / synapse / dendrite / protein-containing complex binding / endoplasmic reticulum membrane / perinuclear region of cytoplasm / signal transduction / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleus / plasma membrane / cytoplasm Similarity search - Function Dendrin / Nephrin and CD2AP-binding protein, Dendrin / Unstructured region on MAGI / Guanylate kinase, conserved site / Guanylate kinase-like signature. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. ... Dendrin / Nephrin and CD2AP-binding protein, Dendrin / Unstructured region on MAGI / Guanylate kinase, conserved site / Guanylate kinase-like signature. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.15 Å DetailsAuthors Zhu, J.W. / Zhang, H.J. / Lin, L. / Zhang, R.G. CitationJournal : To Be Published Title : Phase separation of MAGI2-mediated complex underlies formation of slit diaphragm complex in glomerular filtration barrierAuthors : Zhang, H.J. / Lin, L. / Lin, Z.J. / Liu, J.P. / Pan, L.F. / Zhang, M.J. / Zhu, J.W. / Zhang, R.G. History Deposition Jul 25, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jul 29, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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