Entry Database : PDB / ID : 6kcs Structure visualization Downloads & linksTitle Crystal structure of HIRAN domain of HLTF in complex with duplex DNA ComponentsDNA (5'-D(*AP*CP*TP*GP*TP*AP*CP*GP*TP*AP*CP*AP*GP*T)-3')Helicase-like transcription factor DetailsKeywords DNA BINDING PROTEIN/DNA / DNA complex / DNA BINDING PROTEIN / DNA BINDING PROTEIN-DNA complexFunction / homology Function and homology informationFunction Domain/homology Component
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / ATP-dependent chromatin remodeler activity / regulation of neurogenesis / ATP-dependent activity, acting on DNA / helicase activity / Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement / RING-type E3 ubiquitin transferase / mRNA transcription by RNA polymerase II / nuclear matrix / RNA polymerase II transcription regulator complex ... hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / ATP-dependent chromatin remodeler activity / regulation of neurogenesis / ATP-dependent activity, acting on DNA / helicase activity / Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement / RING-type E3 ubiquitin transferase / mRNA transcription by RNA polymerase II / nuclear matrix / RNA polymerase II transcription regulator complex / ubiquitin protein ligase activity / E3 ubiquitin ligases ubiquitinate target proteins / protein ubiquitination / DNA repair / ubiquitin protein ligase binding / nucleolus / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / zinc ion binding / nucleoplasm / ATP binding / membrane / nucleus / plasma membrane / cytoplasm Similarity search - Function HIRAN domain / HIRAN domain / HIRAN / Zinc finger, C3HC4 type (RING finger) / : / SNF2-like, N-terminal domain superfamily / SNF2, N-terminal / SNF2-related domain / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. ... HIRAN domain / HIRAN domain / HIRAN / Zinc finger, C3HC4 type (RING finger) / : / SNF2-like, N-terminal domain superfamily / SNF2, N-terminal / SNF2-related domain / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger / Helicase conserved C-terminal domain / Zinc finger RING-type profile. / Zinc finger, RING-type / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / Zinc finger, RING/FYVE/PHD-type / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homologyBiological species Homo sapiens (human)synthetic construct (others) Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.1 Å DetailsAuthors Hishiki, A. / Hashimoto, A. Funding support Japan, 3items Details Hide detailsOrganization Grant number Country Japan Society for the Promotion of Science 25291017 Japan Japan Society for the Promotion of Science 16H04755 Japan Japan Society for the Promotion of Science 23770125 Japan
CitationJournal : J.Biochem. / Year : 2020Title : Structure of HIRAN domain of human HLTF bound to duplex DNA provides structural basis for DNA unwinding to initiate replication fork regression.Authors : Hishiki, A. / Sato, M. / Hashimoto, H. History Deposition Jun 28, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jun 10, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Dec 23, 2020 Group : Derived calculationsCategory : pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_assembly_propItem : _pdbx_struct_assembly.details / _pdbx_struct_assembly.method_details ... _pdbx_struct_assembly.details / _pdbx_struct_assembly.method_details / _pdbx_struct_assembly.oligomeric_count / _pdbx_struct_assembly.oligomeric_details Revision 1.2 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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