Entry Database : PDB / ID : 6jck Structure visualization Downloads & linksTitle Complex structure of Axin-DIX and Dvl2-DIX ComponentsAxin-1 Segment polarity protein dishevelled homolog DVL-2 DetailsKeywords SIGNALING PROTEIN / Wnt signallingFunction / homology Function and homology informationFunction Domain/homology Component
beta-catenin destruction complex assembly / Negative regulation of TCF-dependent signaling by DVL-interacting proteins / convergent extension involved in neural plate elongation / armadillo repeat domain binding / head development / segment specification / WNT5A-dependent internalization of FZD4 / cell development / positive regulation of neuron projection arborization / non-canonical Wnt signaling pathway ... beta-catenin destruction complex assembly / Negative regulation of TCF-dependent signaling by DVL-interacting proteins / convergent extension involved in neural plate elongation / armadillo repeat domain binding / head development / segment specification / WNT5A-dependent internalization of FZD4 / cell development / positive regulation of neuron projection arborization / non-canonical Wnt signaling pathway / axial mesoderm formation / dorsal/ventral axis specification / cochlea morphogenesis / clathrin-coated endocytic vesicle / WNT5:FZD7-mediated leishmania damping / post-anal tail morphogenesis / beta-catenin destruction complex / APC truncation mutants have impaired AXIN binding / AXIN missense mutants destabilize the destruction complex / Truncations of AMER1 destabilize the destruction complex / frizzled binding / Beta-catenin phosphorylation cascade / Signaling by GSK3beta mutants / CTNNB1 S33 mutants aren't phosphorylated / CTNNB1 S37 mutants aren't phosphorylated / CTNNB1 S45 mutants aren't phosphorylated / CTNNB1 T41 mutants aren't phosphorylated / epigenetic programming in the zygotic pronuclei / I-SMAD binding / positive regulation of ubiquitin-dependent protein catabolic process / Signaling by Hippo / PCP/CE pathway / Wnt signalosome / WNT mediated activation of DVL / Disassembly of the destruction complex and recruitment of AXIN to the membrane / Wnt signaling pathway, planar cell polarity pathway / nucleocytoplasmic transport / aggresome / negative regulation of protein metabolic process / RUNX1 regulates transcription of genes involved in WNT signaling / RUNX1 regulates estrogen receptor mediated transcription / negative regulation of fat cell differentiation / SMAD binding / positive regulation of transforming growth factor beta receptor signaling pathway / heart looping / R-SMAD binding / outflow tract morphogenesis / negative regulation of transcription elongation by RNA polymerase II / positive regulation of signal transduction by p53 class mediator / lateral plasma membrane / canonical Wnt signaling pathway / ubiquitin-like ligase-substrate adaptor activity / signaling adaptor activity / cytoplasmic microtubule organization / protein serine/threonine kinase binding / protein serine/threonine kinase activator activity / positive regulation of protein ubiquitination / cell periphery / TCF dependent signaling in response to WNT / Asymmetric localization of PCP proteins / regulation of actin cytoskeleton organization / neural tube closure / positive regulation of JNK cascade / Degradation of DVL / Degradation of AXIN / sensory perception of sound / RHO GTPases Activate Formins / negative regulation of canonical Wnt signaling pathway / beta-catenin binding / Degradation of beta-catenin by the destruction complex / small GTPase binding / protein polyubiquitination / positive regulation of protein catabolic process / p53 binding / apical part of cell / intracellular protein localization / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Cargo recognition for clathrin-mediated endocytosis / regulation of cell population proliferation / Clathrin-mediated endocytosis / heart development / microtubule cytoskeleton / protein-containing complex assembly / cytoplasmic vesicle / cell cortex / protein-macromolecule adaptor activity / molecular adaptor activity / Estrogen-dependent gene expression / in utero embryonic development / proteasome-mediated ubiquitin-dependent protein catabolic process / Ub-specific processing proteases / intracellular signal transduction / nuclear body / protein domain specific binding / negative regulation of gene expression / apoptotic process / ubiquitin protein ligase binding / regulation of DNA-templated transcription / protein kinase binding / nucleolus Similarity search - Function Ribosomal Protein L25; Chain P - #130 / Dishevelled-2 / Axin beta-catenin binding / Axin-1/2, tankyrase-binding domain / Axin-like / Axin beta-catenin binding motif / Axin-1 tankyrase binding domain / Dishevelled protein domain / Dishevelled family / Dishevelled C-terminal ... Ribosomal Protein L25; Chain P - #130 / Dishevelled-2 / Axin beta-catenin binding / Axin-1/2, tankyrase-binding domain / Axin-like / Axin beta-catenin binding motif / Axin-1 tankyrase binding domain / Dishevelled protein domain / Dishevelled family / Dishevelled C-terminal / Dishevelled specific domain / Segment polarity protein dishevelled (Dsh) C terminal / Dishevelled-related protein / DIX domain / RGS, subdomain 1/3 / DIX domain superfamily / DIX domain / DIX domain profile. / Domain present in Dishevelled and axin / Ribosomal Protein L25; Chain P / Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) / DEP domain profile. / Domain found in Dishevelled, Egl-10, and Pleckstrin / DEP domain / Regulator of G protein signaling domain / RGS domain / RGS domain profile. / Regulator of G protein signalling domain / RGS, subdomain 2 / RGS domain superfamily / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Ubiquitin-like domain superfamily / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.09 Å DetailsAuthors Yamanishi, K. / Shibata, N. Funding support Japan, 2items Details Hide detailsOrganization Grant number Country Ministry of Education, Culture, Sports, Science and Technology (Japan) 23121526 Japan Ministry of Education, Culture, Sports, Science and Technology (Japan) 25121731 Japan
CitationJournal : Sci.Signal. / Year : 2019Title : A direct heterotypic interaction between the DIX domains of Dishevelled and Axin mediates signaling to beta-catenin.Authors : Yamanishi, K. / Fiedler, M. / Terawaki, S.I. / Higuchi, Y. / Bienz, M. / Shibata, N. History Deposition Jan 29, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jan 15, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less