Entry Database : PDB / ID : 6j7a Structure visualization Downloads & linksTitle Fusion protein of heme oxygenase-1 and NADPH cytochrome P450 reductase (17aa) ComponentsHeme oxygenase 1,NADPH--cytochrome P450 reductase Details Keywords OXIDOREDUCTASE / fusion protein / redox complexFunction / homology Function and homology informationFunction Domain/homology Component
iron-cytochrome-c reductase activity / Regulation of HMOX1 expression and activity / nitrate catabolic process / cellular organofluorine metabolic process / arachidonic acid omega-hydroxylase activity / Iron uptake and transport / demethylation / response to 3-methylcholanthrene / Heme degradation / carnitine metabolic process ... iron-cytochrome-c reductase activity / Regulation of HMOX1 expression and activity / nitrate catabolic process / cellular organofluorine metabolic process / arachidonic acid omega-hydroxylase activity / Iron uptake and transport / demethylation / response to 3-methylcholanthrene / Heme degradation / carnitine metabolic process / flavonoid metabolic process / Cytoprotection by HMOX1 / nitric oxide dioxygenase NAD(P)H activity / negative regulation of mast cell degranulation / response to arachidonic acid / heme metabolic process / cellular response to gonadotropin stimulus / regulation of growth plate cartilage chondrocyte proliferation / nitric oxide catabolic process / cytochrome-b5 reductase activity, acting on NAD(P)H / phospholipase D activity / heme oxygenase (biliverdin-producing) / positive regulation of steroid hormone biosynthetic process / cellular response to cisplatin / heme oxidation / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / positive regulation of chondrocyte differentiation / heme oxygenase (decyclizing) activity / wound healing involved in inflammatory response / negative regulation of muscle cell apoptotic process / cellular response to follicle-stimulating hormone stimulus / positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / negative regulation of mast cell cytokine production / positive regulation of cholesterol biosynthetic process / heme catabolic process / cellular response to arsenic-containing substance / cellular response to nutrient / negative regulation of epithelial cell apoptotic process / NADPH-hemoprotein reductase / NADPH-hemoprotein reductase activity / positive regulation of smoothened signaling pathway / positive regulation of epithelial cell apoptotic process / erythrocyte homeostasis / cellular response to peptide hormone stimulus / epithelial cell apoptotic process / regulation of cholesterol metabolic process / positive regulation of cell migration involved in sprouting angiogenesis / small GTPase-mediated signal transduction / negative regulation of macroautophagy / response to dexamethasone / fatty acid oxidation / negative regulation of vascular associated smooth muscle cell proliferation / positive regulation of macroautophagy / phospholipid metabolic process / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / cellular response to cadmium ion / response to nutrient / response to hormone / caveola / liver regeneration / macroautophagy / electron transport chain / negative regulation of smooth muscle cell proliferation / positive regulation of smooth muscle cell proliferation / response to nicotine / response to hydrogen peroxide / regulation of blood pressure / multicellular organismal-level iron ion homeostasis / response to estrogen / positive regulation of angiogenesis / intrinsic apoptotic signaling pathway in response to DNA damage / FMN binding / NADP binding / cellular response to heat / flavin adenine dinucleotide binding / cellular response to hypoxia / angiogenesis / intracellular iron ion homeostasis / response to oxidative stress / negative regulation of neuron apoptotic process / oxidoreductase activity / electron transfer activity / hydrolase activity / response to hypoxia / intracellular signal transduction / response to xenobiotic stimulus / negative regulation of cell population proliferation / intracellular membrane-bounded organelle / heme binding / endoplasmic reticulum membrane / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / structural molecule activity / perinuclear region of cytoplasm / enzyme binding / endoplasmic reticulum / protein homodimerization activity / identical protein binding / nucleus / metal ion binding Similarity search - Function NADPH-cytochrome P450 reductase / Haem oxygenase conserved site / Heme oxygenase signature. / Haem oxygenase / Haem oxygenase-like / Heme oxygenase / Haem oxygenase-like, multi-helical / Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding / NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily / FAD binding domain ... NADPH-cytochrome P450 reductase / Haem oxygenase conserved site / Heme oxygenase signature. / Haem oxygenase / Haem oxygenase-like / Heme oxygenase / Haem oxygenase-like, multi-helical / Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding / NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily / FAD binding domain / Flavodoxin-like / Flavoprotein pyridine nucleotide cytochrome reductase / Flavodoxin / Flavodoxin-like domain profile. / Flavodoxin/nitric oxide synthase / Oxidoreductase FAD/NAD(P)-binding / Oxidoreductase NAD-binding domain / FAD-binding domain, ferredoxin reductase-type / Ferredoxin-NADP reductase (FNR), nucleotide-binding domain / Ferredoxin reductase-type FAD binding domain profile. / Riboflavin synthase-like beta-barrel / Flavoprotein-like superfamily Similarity search - Domain/homology FLAVIN-ADENINE DINUCLEOTIDE / FLAVIN MONONUCLEOTIDE / PROTOPORPHYRIN IX CONTAINING FE / NADPH--cytochrome P450 reductase / Heme oxygenase 1 Similarity search - ComponentBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.269 Å DetailsAuthors Sugishima, M. / Sato, H. / Wada, K. / Yamamoto, K. Funding support Japan, 2items Details Hide detailsOrganization Grant number Country Japan Society for the Promotion of Science 16K07280 Japan Japan Society for the Promotion of Science 25840026 Japan
CitationJournal : Febs Lett. / Year : 2019Title : Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP+binding.Authors : Sugishima, M. / Sato, H. / Wada, K. / Yamamoto, K. History Deposition Jan 17, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Apr 10, 2019 Provider : repository / Type : Initial releaseRevision 1.1 May 15, 2019 Group : Data collection / Database references / Category : citation / citation_authorItem : _citation.journal_abbrev / _citation.journal_id_ISSN ... _citation.journal_abbrev / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID Revision 1.2 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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