- PDB-6if5: Crystal structure of monkey TLR7 in complex with 2',3'-cGMP (Guan... -
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基本情報
登録情報
データベース: PDB / ID: 6if5
タイトル
Crystal structure of monkey TLR7 in complex with 2',3'-cGMP (Guanosine 2',3'-cyclic phosphate)
要素
Toll-like receptor 7
キーワード
IMMUNE SYSTEM / Innate immunity Toll-like receptors
機能・相同性
機能・相同性情報
toll-like receptor 7 signaling pathway / response to cGMP / siRNA binding / early phagosome / positive regulation of macrophage cytokine production / pattern recognition receptor activity / toll-like receptor signaling pathway / canonical NF-kappaB signal transduction / positive regulation of interferon-alpha production / positive regulation of chemokine production ...toll-like receptor 7 signaling pathway / response to cGMP / siRNA binding / early phagosome / positive regulation of macrophage cytokine production / pattern recognition receptor activity / toll-like receptor signaling pathway / canonical NF-kappaB signal transduction / positive regulation of interferon-alpha production / positive regulation of chemokine production / JNK cascade / positive regulation of interferon-beta production / positive regulation of interleukin-8 production / regulation of protein phosphorylation / cellular response to virus / positive regulation of non-canonical NF-kappaB signal transduction / cellular response to mechanical stimulus / positive regulation of interleukin-6 production / positive regulation of type II interferon production / double-stranded RNA binding / defense response to virus / single-stranded RNA binding / lysosome / receptor complex / endosome / inflammatory response / innate immune response / endoplasmic reticulum / positive regulation of transcription by RNA polymerase II / metal ion binding / plasma membrane 類似検索 - 分子機能
The residues 440-445 (SEVGFC) are replaced by a thrombin-cleavage sequence (LVPRGS) for artificial ...The residues 440-445 (SEVGFC) are replaced by a thrombin-cleavage sequence (LVPRGS) for artificial cleavage of Z-loop. This engineered site in Z-loop was further cleaved during purification and the cleaved protein remained associated via interactions between LRRs and a disulfide bond. Therefore, although cleaved, the cleaved version of protein is considered as one single component (chain).
プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
放射波長
波長: 1 Å / 相対比: 1
反射
解像度: 2→50 Å / Num. obs: 133746 / % possible obs: 100 % / 冗長度: 6.8 % / Net I/σ(I): 17.8
反射 シェル
解像度: 2→2.03 Å
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解析
ソフトウェア
名称
バージョン
分類
REFMAC
5.8.0230
精密化
XDS
データ削減
Aimless
データスケーリング
MOLREP
位相決定
精密化
構造決定の手法: 分子置換 / 解像度: 2→47.18 Å / Cor.coef. Fo:Fc: 0.966 / Cor.coef. Fo:Fc free: 0.95 / SU B: 3.811 / SU ML: 0.105 / 交差検証法: THROUGHOUT / ESU R: 0.152 / ESU R Free: 0.145 / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS