Entry Database : PDB / ID : 6i6m Structure visualization Downloads & linksTitle Papaver somniferum O-methyltransferase 1 ComponentsO-methyltransferase 1 Details Keywords TRANSFERASE / SAM-dependent O-methyltransferase / Papaver somniferum / tetrahydrocolumbamine / s-adenosyl homocysteine / noscapine / benzylisoquinoline alkaloidFunction / homology Function and homology informationFunction Domain/homology Component
tetrahydrocolumbamine 2-O-methyltransferase / benzyl isoquinoline alkaloid biosynthetic process / tetrahydrocolumbamine 2-O-methyltransferase activity / (S)-scoulerine 9-O-methyltransferase / (S)-scoulerine 9-O-methyltransferase activity / : / O-methyltransferase activity / Transferases; Transferring one-carbon groups; Methyltransferases / methyltransferase activity / methylation / protein dimerization activity Similarity search - Function Plant methyltransferase dimerisation / Dimerisation domain / O-methyltransferase domain / O-methyltransferase domain / SAM-dependent O-methyltransferase class II-type profile. / O-methyltransferase COMT-type / Vaccinia Virus protein VP39 / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / S-adenosyl-L-methionine-dependent methyltransferase superfamily ... Plant methyltransferase dimerisation / Dimerisation domain / O-methyltransferase domain / O-methyltransferase domain / SAM-dependent O-methyltransferase class II-type profile. / O-methyltransferase COMT-type / Vaccinia Virus protein VP39 / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Papaver somniferum (opium poppy)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.2 Å DetailsAuthors Cabry, M.P. / Offen, W.A. / Winzer, T. / Li, Y. / Graham, I.A. / Davies, G.J. / Saleh, P. Funding support United Kingdom, 1items Details Hide detailsOrganization Grant number Country Biotechnology and Biological Sciences Research Council BB/M011151/1 United Kingdom
CitationJournal : Acs Catalysis / Year : 2019Title : Structure of Papaver somniferum O-Methyltransferase 1 Reveals Initiation of Noscapine Biosynthesis with Implications for Plant Natural Product MethylationAuthors : Cabry, M.P. / Offen, W.A. / Winzer, T.H. / Li, Y. / Graham, I.A. / Davies, G.J. / Saleh, P. History Deposition Nov 15, 2018 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 27, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Apr 10, 2019 Group : Data collection / Database references / Category : citation / Item : _citation.pdbx_database_id_DOIRevision 1.2 Jan 24, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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