Entry | Database: PDB / ID: 6hro |
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Title | Crystal structure of Ebolavirus glycoprotein in complex with inhibitor 118a |
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Components | - Envelope glycoprotein
- Envelope glycoprotein,Envelope glycoprotein,Envelope glycoprotein
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Keywords | VIRAL PROTEIN / Ebola Glycoprotein / Structure-based In Silico Screening / 118a / Natural compound |
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Function / homology | Function and homology information
host cell endoplasmic reticulum / viral budding from plasma membrane / clathrin-dependent endocytosis of virus by host cell / suppression by virus of host tetherin activity / host cell cytoplasm / entry receptor-mediated virion attachment to host cell / symbiont entry into host cell / membrane raft / fusion of virus membrane with host endosome membrane / viral envelope ...host cell endoplasmic reticulum / viral budding from plasma membrane / clathrin-dependent endocytosis of virus by host cell / suppression by virus of host tetherin activity / host cell cytoplasm / entry receptor-mediated virion attachment to host cell / symbiont entry into host cell / membrane raft / fusion of virus membrane with host endosome membrane / viral envelope / lipid binding / host cell plasma membrane / virion membrane / extracellular region / identical protein bindingSimilarity search - Function |
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Biological species | ![](img/tx_virus.gif) Zaire ebolavirus |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 2.3 Å |
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Authors | Ren, J. / Zhao, Y. / Stuart, D.I. |
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Funding support | United Kingdom, 1items Organization | Grant number | Country |
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| | United Kingdom |
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Citation | Journal: J.Med.Chem. / Year: 2019 Title: Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library. Authors: Shaikh, F. / Zhao, Y. / Alvarez, L. / Iliopoulou, M. / Lohans, C. / Schofield, C.J. / Padilla-Parra, S. / Siu, S.W.I. / Fry, E.E. / Ren, J. / Stuart, D.I. |
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History | Deposition | Sep 27, 2018 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Feb 27, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Mar 6, 2019 | Group: Data collection / Structure summary / Category: pdbx_seq_map_depositor_info / struct_keywords Item: _pdbx_seq_map_depositor_info.one_letter_code_mod / _struct_keywords.pdbx_keywords / _struct_keywords.text |
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Revision 1.2 | Apr 10, 2019 | Group: Data collection / Database references Category: citation / citation_author ...citation / citation_author / database_PDB_rev / database_PDB_rev_record / pdbx_database_proc / pdbx_seq_map_depositor_info Item: _citation.journal_abbrev / _citation.journal_id_ISSN ..._citation.journal_abbrev / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.name / _pdbx_seq_map_depositor_info.one_letter_code_mod |
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Revision 2.0 | Jul 29, 2020 | Group: Atomic model / Data collection ...Atomic model / Data collection / Derived calculations / Structure summary Category: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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