- PDB-6hdo: Crystal structure of human ATAD2 bromodomain in complex with 8-((... -
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基本情報
登録情報
データベース: PDB / ID: 6hdo
タイトル
Crystal structure of human ATAD2 bromodomain in complex with 8-(((1R,2R,3R,5S)-2-(2-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)quinolin-2(1H)-one
要素
ATPase family AAA domain-containing protein 2
キーワード
TRANSCRIPTION / INHIBITOR / ATAD2 / BROMODOMAIN / EPIGENETICS / ATPase family AAA domain-containing protein 2
機能・相同性
機能・相同性情報
加水分解酵素; 酸無水物に作用; リン含有酸無水物に作用 / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / histone binding / chromatin binding / positive regulation of DNA-templated transcription / ATP hydrolysis activity / positive regulation of transcription by RNA polymerase II / extracellular exosome / nucleoplasm / ATP binding / nucleus 類似検索 - 分子機能
ATPase family AAA domain-containing protein ATAD2-like / AAA ATPase, AAA+ lid domain / AAA+ lid domain / ATPase, AAA-type, conserved site / AAA-protein family signature. / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain ...ATPase family AAA domain-containing protein ATAD2-like / AAA ATPase, AAA+ lid domain / AAA+ lid domain / ATPase, AAA-type, conserved site / AAA-protein family signature. / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / Up-down Bundle / P-loop containing nucleoside triphosphate hydrolase / Mainly Alpha 類似検索 - ドメイン・相同性
Chem-FZH / ATPase family AAA domain-containing protein 2 類似検索 - 構成要素
プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
放射波長
波長: 1.54178 Å / 相対比: 1
反射
解像度: 2.61→135.03 Å / Num. obs: 8153 / % possible obs: 99.6 % / 冗長度: 10.3 % / Net I/σ(I): 20.8
反射 シェル
解像度: 2.61→2.75 Å / 冗長度: 10.7 % / % possible all: 100
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解析
ソフトウェア
名称
バージョン
分類
REFMAC
5.8.0073
精密化
XDS
データ削減
SCALA
データスケーリング
精密化
解像度: 2.61→37.64 Å / Cor.coef. Fo:Fc: 0.945 / Cor.coef. Fo:Fc free: 0.925 / SU B: 24.134 / SU ML: 0.555 / 交差検証法: THROUGHOUT / ESU R: 0.356 / ESU R Free: 0.254 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.23194
374
4.6 %
RANDOM
Rwork
0.18427
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obs
0.18646
7735
99.82 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: BABINET MODEL WITH MASK