登録情報 データベース : PDB / ID : 6h6a 構造の表示 ダウンロードとリンクタイトル Crystal structure of UNC119 in complex with LCK peptide 要素(Protein unc-119 homolog ...) x 2 GLY-CYS-GLY-CYS-SER-SER 詳細キーワード IMMUNE SYSTEM / Complex / Transport / Kinase機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of caveolin-mediated endocytosis / negative regulation of clathrin-dependent endocytosis / regulation of lymphocyte activation / positive regulation of leukocyte cell-cell adhesion / Fc-gamma receptor signaling pathway / CD28 co-stimulation / intracellular zinc ion homeostasis / FLT3 signaling through SRC family kinases / CD4 receptor binding / Nef Mediated CD4 Down-regulation ... negative regulation of caveolin-mediated endocytosis / negative regulation of clathrin-dependent endocytosis / regulation of lymphocyte activation / positive regulation of leukocyte cell-cell adhesion / Fc-gamma receptor signaling pathway / CD28 co-stimulation / intracellular zinc ion homeostasis / FLT3 signaling through SRC family kinases / CD4 receptor binding / Nef Mediated CD4 Down-regulation / Nef and signal transduction / positive regulation of heterotypic cell-cell adhesion / Interleukin-2 signaling / CD28 dependent Vav1 pathway / lipoprotein transport / Regulation of KIT signaling / CTLA4 inhibitory signaling / protein serine/threonine phosphatase activity / intercellular bridge / leukocyte migration / phospholipase activator activity / CD8 receptor binding / pericentriolar material / positive regulation of T cell receptor signaling pathway / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / PECAM1 interactions / CD28 dependent PI3K/Akt signaling / phospholipase binding / phototransduction / RHOH GTPase cycle / hemopoiesis / Generation of second messenger molecules / immunological synapse / positive regulation of protein tyrosine kinase activity / T cell differentiation / mitotic cytokinesis / PD-1 signaling / spindle midzone / phosphatidylinositol 3-kinase binding / T cell receptor binding / positive regulation of intrinsic apoptotic signaling pathway / peptidyl-tyrosine autophosphorylation / release of sequestered calcium ion into cytosol / extrinsic component of cytoplasmic side of plasma membrane / GPVI-mediated activation cascade / cell surface receptor protein tyrosine kinase signaling pathway / T cell costimulation / visual perception / phosphotyrosine residue binding / SH2 domain binding / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / B cell receptor signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / Signaling by SCF-KIT / platelet activation / spindle pole / peptidyl-tyrosine phosphorylation / endocytosis / Constitutive Signaling by Aberrant PI3K in Cancer / activation of cysteine-type endopeptidase activity involved in apoptotic process / Downstream TCR signaling / positive regulation of T cell activation / PIP3 activates AKT signaling / DAP12 signaling / nervous system development / T cell receptor signaling pathway / ATPase binding / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / chemical synaptic transmission / protein phosphatase binding / protein tyrosine kinase activity / intracellular signal transduction / response to xenobiotic stimulus / membrane raft / protein phosphorylation / innate immune response / signaling receptor binding / centrosome / lipid binding / synapse / protein kinase binding / extracellular exosome / ATP binding / identical protein binding / plasma membrane / cytosol 類似検索 - 分子機能 GMP phosphodiesterase, delta subunit / GMP phosphodiesterase, delta subunit / GMP phosphodiesterase, delta subunit superfamily / GMP-PDE, delta subunit / Lck, SH3 domain / Tyrosine-protein kinase Lck, SH2 domain / Coagulation Factor XIII; Chain A, domain 1 / SH3 domain / Distorted Sandwich / SH2 domain ... GMP phosphodiesterase, delta subunit / GMP phosphodiesterase, delta subunit / GMP phosphodiesterase, delta subunit superfamily / GMP-PDE, delta subunit / Lck, SH3 domain / Tyrosine-protein kinase Lck, SH2 domain / Coagulation Factor XIII; Chain A, domain 1 / SH3 domain / Distorted Sandwich / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Immunoglobulin E-set / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta 類似検索 - ドメイン・相同性 MYRISTIC ACID / PHOSPHATE ION / Tyrosine-protein kinase Lck / Protein unc-119 homolog A 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 2 Å 詳細データ登録者 Yelland, T. / ElMaghloob, Y. / McIlwraith, M. / Stephen, L. / Ismail, S. 資金援助 英国, 1件 詳細 詳細を隠す組織 認可番号 国 Cancer Research UK 英国
引用ジャーナル : Dev.Cell / 年 : 2018タイトル : The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.著者 : Stephen, L.A. / ElMaghloob, Y. / McIlwraith, M.J. / Yelland, T. / Castro Sanchez, P. / Roda-Navarro, P. / Ismail, S. 履歴 登録 2018年7月26日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2018年9月26日 Provider : repository / タイプ : Initial release改定 1.1 2019年4月10日 Group : Data collection / Database referencesカテゴリ : citation / citation_author / pdbx_database_procItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2019年10月16日 Group : Data collection / カテゴリ : reflns_shell改定 1.3 2019年11月27日 Group : Derived calculationsカテゴリ : pdbx_struct_assembly / pdbx_struct_assembly_gen ... pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop / pdbx_struct_oper_list Item : _pdbx_struct_assembly_gen.assembly_id / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_assembly_gen.oper_expression
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