登録情報 | データベース: PDB / ID: 6h2u |
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タイトル | Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 1.6A resolution |
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要素 | - Methyltransferase-like protein 5
- Multifunctional methyltransferase subunit TRM112-like protein
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キーワード | TRANSFERASE / rRNA maturation / methyltransferase / translation / ribosome synthesis |
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機能・相同性 | 機能・相同性情報
rRNA (adenine-N6-)-methyltransferase activity / peptidyl-glutamine methylation / rRNA (guanine-N7)-methylation / tRNA methyltransferase activator activity / tRNA modification in the nucleus and cytosol / Methylation / protein methyltransferase activity / tRNA methylation / positive regulation of rRNA processing / S-adenosyl-L-methionine binding ...rRNA (adenine-N6-)-methyltransferase activity / peptidyl-glutamine methylation / rRNA (guanine-N7)-methylation / tRNA methyltransferase activator activity / tRNA modification in the nucleus and cytosol / Methylation / protein methyltransferase activity / tRNA methylation / positive regulation of rRNA processing / S-adenosyl-L-methionine binding / rRNA methylation / rRNA modification in the nucleus and cytosol / Eukaryotic Translation Termination / transcription initiation-coupled chromatin remodeling / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / cell projection / positive regulation of translation / stem cell differentiation / presynapse / transferase activity / postsynapse / nucleic acid binding / protein heterodimerization activity / perinuclear region of cytoplasm / protein-containing complex / nucleoplasm / nucleus / cytosol類似検索 - 分子機能 Multifunctional methyltransferase subunit Trm112 / Trm112-like / Trm112p-like protein / Methyltransferase small domain / Methyltransferase small domain / N-6 Adenine-specific DNA methylases signature. / DNA methylase, N-6 adenine-specific, conserved site / S-adenosyl-L-methionine-dependent methyltransferase superfamily類似検索 - ドメイン・相同性 S-ADENOSYLMETHIONINE / rRNA N6-adenosine-methyltransferase METTL5 / Multifunctional methyltransferase subunit TRM112-like protein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.6 Å |
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データ登録者 | van Tran, N. / Graille, M. |
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資金援助 | フランス, 2件 組織 | 認可番号 | 国 |
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French National Research Agency | ANR-14-CE09-0016 | フランス | French National Research Agency | ANR-16-CE11-0003 | フランス |
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引用 | ジャーナル: Nucleic Acids Res. / 年: 2019 タイトル: The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. 著者: van Tran, N. / Ernst, F.G.M. / Hawley, B.R. / Zorbas, C. / Ulryck, N. / Hackert, P. / Bohnsack, K.E. / Bohnsack, M.T. / Jaffrey, S.R. / Graille, M. / Lafontaine, D.L.J. |
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履歴 | 登録 | 2018年7月16日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年7月31日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年9月18日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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