- PDB-6gy2: Crystal structure of human Plk1-PBD in complex with WSSSLATPPTLSS... -
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基本情報
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データベース: PDB / ID: 6gy2
タイトル
Crystal structure of human Plk1-PBD in complex with WSSSLATPPTLSSpTVLI phosphopeptide from BRCA2
要素
Phosphopeptide of BRCA2
Serine/threonine-protein kinase PLK1
キーワード
CELL CYCLE / phosphorylation / chromosomes alignement / DNA repair
機能・相同性
機能・相同性情報
BRCA2-MAGE-D1 complex / negative regulation of mammary gland epithelial cell proliferation / mitotic recombination-dependent replication fork processing / regulation of anaphase-promoting complex-dependent catabolic process / Mitotic Telophase/Cytokinesis / regulation of protein localization to cell cortex / Mitotic Metaphase/Anaphase Transition / synaptonemal complex disassembly / Golgi inheritance / establishment of protein localization to telomere ...BRCA2-MAGE-D1 complex / negative regulation of mammary gland epithelial cell proliferation / mitotic recombination-dependent replication fork processing / regulation of anaphase-promoting complex-dependent catabolic process / Mitotic Telophase/Cytokinesis / regulation of protein localization to cell cortex / Mitotic Metaphase/Anaphase Transition / synaptonemal complex disassembly / Golgi inheritance / establishment of protein localization to telomere / Activation of NIMA Kinases NEK9, NEK6, NEK7 / homologous chromosome segregation / nuclear membrane disassembly / regulation of protein binding / polo kinase / mitotic nuclear membrane disassembly / Impaired BRCA2 translocation to the nucleus / Impaired BRCA2 binding to SEM1 (DSS1) / centrosome duplication / protein localization to nuclear envelope / Phosphorylation of Emi1 / nuclear ubiquitin ligase complex / metaphase/anaphase transition of mitotic cell cycle / synaptonemal complex / female meiosis chromosome segregation / lateral element / anaphase-promoting complex binding / outer kinetochore / Phosphorylation of the APC/C / telomere maintenance via recombination / histone H4 acetyltransferase activity / histone H3 acetyltransferase activity / regulation of DNA damage checkpoint / negative regulation of cyclin-dependent protein serine/threonine kinase activity / positive regulation of ubiquitin protein ligase activity / Impaired BRCA2 binding to PALB2 / regulation of mitotic spindle assembly / microtubule bundle formation / HDR through MMEJ (alt-NHEJ) / gamma-tubulin binding / Polo-like kinase mediated events / mitotic chromosome condensation / Golgi Cisternae Pericentriolar Stack Reorganization / Regulation of MITF-M-dependent genes involved in cell cycle and proliferation / sister chromatid cohesion / DNA repair complex / centrosome cycle / regulation of mitotic metaphase/anaphase transition / Defective homologous recombination repair (HRR) due to BRCA1 loss of function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function / Homologous DNA Pairing and Strand Exchange / Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) / positive regulation of ubiquitin-protein transferase activity / response to UV-C / oocyte maturation / Resolution of D-loop Structures through Holliday Junction Intermediates / regulation of mitotic cell cycle phase transition / inner cell mass cell proliferation / DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / hematopoietic stem cell proliferation / Impaired BRCA2 binding to RAD51 / double-strand break repair via alternative nonhomologous end joining / female gonad development / mitotic spindle assembly checkpoint signaling / Cyclin A/B1/B2 associated events during G2/M transition / mitotic spindle pole / male meiosis I / regulation of mitotic cell cycle / establishment of mitotic spindle orientation / mitotic sister chromatid segregation / mitotic G2 DNA damage checkpoint signaling / Presynaptic phase of homologous DNA pairing and strand exchange / positive regulation of proteolysis / mitotic cytokinesis / centriolar satellite / response to X-ray / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / spindle midzone / negative regulation of double-strand break repair via homologous recombination / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / Loss of Nlp from mitotic centrosomes / Loss of proteins required for interphase microtubule organization from the centrosome / Recruitment of mitotic centrosome proteins and complexes / protein localization to chromatin / Recruitment of NuMA to mitotic centrosomes / Anchoring of the basal body to the plasma membrane / Resolution of Sister Chromatid Cohesion / centriole / AURKA Activation by TPX2 / positive regulation of mitotic cell cycle / Condensation of Prophase Chromosomes / mitotic spindle organization / regulation of cytokinesis / positive regulation of peptidyl-threonine phosphorylation / Meiotic recombination / secretory granule / RHO GTPases Activate Formins 類似検索 - 分子機能
: / BRCA2, OB2 / BRCA2, OB3 / Tower domain / Breast cancer type 2 susceptibility protein, helical domain / BRCA2 helical domain superfamily / BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 / Tower / BRCA2, helical / Tower ...: / BRCA2, OB2 / BRCA2, OB3 / Tower domain / Breast cancer type 2 susceptibility protein, helical domain / BRCA2 helical domain superfamily / BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 / Tower / BRCA2, helical / Tower / BRCA2 repeat / BRCA2, OB1 / Breast cancer type 2 susceptibility protein / BRCA2 repeat / BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 / BRCA2 repeat profile. / POLO box domain / Polo-like kinase 1, catalytic domain / Second polo-box domain / First polo-box domain / POLO box domain superfamily / POLO box duplicated region / POLO box domain / POLO box domain profile. / Arylsulfatase, C-terminal domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Nucleic acid-binding, OB-fold / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性
Breast cancer type 2 susceptibility protein / Serine/threonine-protein kinase PLK1 類似検索 - 構成要素
分子量: 28193.098 Da / 分子数: 2 / 由来タイプ: 組換発現 / 詳細: the six first residues AMDPEF are part of LINKER / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: PLK1, PLK / 発現宿主: Escherichia coli BL21(DE3) (大腸菌) / 参照: UniProt: P53350, polo kinase
#2: タンパク質・ペプチド
PhosphopeptideofBRCA2
分子量: 1839.975 Da / 分子数: 2 / 由来タイプ: 合成 / 由来: (合成) Homo sapiens (ヒト) / 参照: UniProt: P51587*PLUS