- PDB-6gg1: Structure of PROSS-edited human interleukin 24 -
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Open data
ID or keywords:
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Basic information
Entry
Database: PDB / ID: 6gg1
Title
Structure of PROSS-edited human interleukin 24
Components
Interleukin-24
Keywords
CYTOKINE / IL-10 family / immunity / automated design / cancer
Function / homology
Function and homology information
serine phosphorylation of STAT protein / Interleukin-20 family signaling / cellular response to interleukin-4 / positive regulation of tyrosine phosphorylation of STAT protein / negative regulation of cell migration / cytokine activity / wound healing / cellular response to lipopolysaccharide / negative regulation of cell population proliferation / apoptotic process ...serine phosphorylation of STAT protein / Interleukin-20 family signaling / cellular response to interleukin-4 / positive regulation of tyrosine phosphorylation of STAT protein / negative regulation of cell migration / cytokine activity / wound healing / cellular response to lipopolysaccharide / negative regulation of cell population proliferation / apoptotic process / positive regulation of cell population proliferation / extracellular space / extracellular region Similarity search - Function
Interleukin-24 / Interleukin-10, conserved site / Interleukin-10 family signature. / Four-helical cytokine-like, core Similarity search - Domain/homology
Resolution: 1.3→46.96 Å / Cor.coef. Fo:Fc: 0.972 / SU B: 1.535 / SU ML: 0.03 / Cross valid method: THROUGHOUT / ESU R: 0.047 / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.18345
2083
4.8 %
RANDOM
Rwork
0.16063
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obs
0.1676
43092
99.97 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å