Entry Database : PDB / ID : 6g2k Structure visualization Downloads & linksTitle Structure of HuR RRM3 in complex with RNA (UUUUUU) ComponentsELAV-like protein 1 RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3') DetailsKeywords RNA BINDING PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
HuR (ELAVL1) binds and stabilizes mRNA / negative regulation of miRNA-mediated gene silencing / post-transcriptional gene silencing / regulation of stem cell population maintenance / mRNA 3'-UTR AU-rich region binding / mRNA stabilization / lncRNA binding / miRNA binding / 3'-UTR-mediated mRNA stabilization / mRNA destabilization ... HuR (ELAVL1) binds and stabilizes mRNA / negative regulation of miRNA-mediated gene silencing / post-transcriptional gene silencing / regulation of stem cell population maintenance / mRNA 3'-UTR AU-rich region binding / mRNA stabilization / lncRNA binding / miRNA binding / 3'-UTR-mediated mRNA stabilization / mRNA destabilization / sarcoplasm / positive regulation of superoxide anion generation / mRNA 3'-UTR binding / positive regulation of translation / P-body / protein homooligomerization / cytoplasmic stress granule / protein import into nucleus / double-stranded RNA binding / cytoplasmic vesicle / postsynapse / ribonucleoprotein complex / mRNA binding / glutamatergic synapse / protein kinase binding / endoplasmic reticulum / protein homodimerization activity / RNA binding / nucleoplasm / membrane / nucleus / cytoplasm / cytosol Similarity search - Function HuR, RNA recognition motif 2 / Splicing factor ELAV/Hu / Paraneoplastic encephalomyelitis antigen / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nucleotide-binding alpha-beta plait domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)synthetic construct (others) Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.01 Å DetailsAuthors Pabis, M. / Sattler, M. Funding support Germany, 1items Details Hide detailsOrganization Grant number Country German Research Foundation SFB1035 Germany
CitationJournal : Nucleic Acids Res. / Year : 2019Title : HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs.Authors : Pabis, M. / Popowicz, G.M. / Stehle, R. / Fernandez-Ramos, D. / Asami, S. / Warner, L. / Garcia-Maurino, S.M. / Schlundt, A. / Martinez-Chantar, M.L. / Diaz-Moreno, I. / Sattler, M. History Deposition Mar 23, 2018 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 31, 2018 Provider : repository / Type : Initial releaseRevision 1.1 May 15, 2019 Group : Data collection / Database referencesCategory : citation / citation_author ... citation / citation_author / pdbx_database_proc / pdbx_seq_map_depositor_info Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _pdbx_seq_map_depositor_info.one_letter_code
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