登録情報 データベース : PDB / ID : 6ful 構造の表示 ダウンロードとリンクタイトル Crystal structure of UTX complexed with 5-hydroxy-4-keto-1-methyl-picolinate 要素Lysine-specific demethylase 6A 詳細 キーワード OXIDOREDUCTASE / Jumonji Demethylase / Inhibitor機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
[histone H3]-trimethyl-L-lysine27 demethylase / histone H3K27me2/H3K27me3 demethylase activity / MLL3/4 complex / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes / histone demethylase activity / Chromatin modifications during the maternal to zygotic transition (MZT) / HDMs demethylate histones / chromatin DNA binding / Activation of anterior HOX genes in hindbrain development during early embryogenesis ... [histone H3]-trimethyl-L-lysine27 demethylase / histone H3K27me2/H3K27me3 demethylase activity / MLL3/4 complex / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes / histone demethylase activity / Chromatin modifications during the maternal to zygotic transition (MZT) / HDMs demethylate histones / chromatin DNA binding / Activation of anterior HOX genes in hindbrain development during early embryogenesis / regulation of gene expression / chromatin remodeling / RNA polymerase II cis-regulatory region sequence-specific DNA binding / nucleoplasm / nucleus / metal ion binding 類似検索 - 分子機能 Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1370 / Cysteine Rich Protein - #20 / : / : / : / : / Lysine-specific demethylase 6/UTY, C-terminal helical domain / KDM6, GATA-like / Cysteine Rich Protein / Tetratricopeptide repeat ... Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1370 / Cysteine Rich Protein - #20 / : / : / : / : / Lysine-specific demethylase 6/UTY, C-terminal helical domain / KDM6, GATA-like / Cysteine Rich Protein / Tetratricopeptide repeat / Tetratricopeptide repeat / Cupin / JmjC domain, hydroxylase / A domain family that is part of the cupin metalloenzyme superfamily. / JmjC domain / JmjC domain profile. / TPR repeat region circular profile. / TPR repeat profile. / Tetratricopeptide repeats / Tetratricopeptide repeat / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Ribbon / Tetratricopeptide-like helical domain superfamily / Jelly Rolls / Up-down Bundle / Sandwich / Mainly Beta / Mainly Alpha 類似検索 - ドメイン・相同性 Chem-E7Z / : / Lysine-specific demethylase 6A 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.649 Å 詳細データ登録者 Esposito, C. / Sledz, P. / Caflisch, A. 引用ジャーナル : J Chem Inf Model / 年 : 2018タイトル : In Silico Identification of JMJD3 Demethylase Inhibitors.著者 : Esposito, C. / Wiedmer, L. / Caflisch, A. 履歴 登録 2018年2月27日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2018年10月10日 Provider : repository / タイプ : Initial release改定 1.1 2018年10月31日 Group : Data collection / Database references / Structure summaryカテゴリ : citation / citation_author / entityItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID / _entity.formula_weight 改定 1.2 2024年1月17日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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