ジャーナル: To Be Published タイトル: Solution structure of a last generation macrocyclic inhibitor. Hepatitis C virus NS3 protease complex: when S prime region occupancy is not enough to stabilize the protein conformation ...タイトル: Solution structure of a last generation macrocyclic inhibitor. Hepatitis C virus NS3 protease complex: when S prime region occupancy is not enough to stabilize the protein conformation in the absence of NS4A. 著者: Gallo, M. / Eliseo, T. / Monteagudo, E.S. / Sabetta, S. / Paci, M. / Summa, V. / Cicero, D.O.
500 uM [U-99% 15N] HCV NS3 protease, 500 uM NA P2P4M, 100 mM NA sodium chloride, 0.3 % deuterated n-octyl beta-D-glucopyranoside, 1 mM NA DTT, 0.01 % NA sodium azide, 95% H2O/5% D2O
500 uM [U-99% 15N] [U-99% 13C] HCV NS3 protease, 500 uM NA P2P4M, 100 mM NA sodium chloride, 0.3 % deuterated n-octyl beta-D-glucopyranoside, 1 mM NA DTT, 0.01 % NA sodium azide, 95% H2O/5% D2O
500 uM [U-99% 15N] [U-99% 13C] HCV NS3 protease, 500 uM NA P2P4M, 100 mM NA sodium chloride, 0.3 % deuterated n-octyl beta-D-glucopyranoside, 1 mM NA DTT, 0.01 % NA sodium azide, 100% D2O