登録情報 | データベース: PDB / ID: 6fad |
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タイトル | SR protein kinase 1 (SRPK1) in complex with the RGG-box of HSV1 ICP27 |
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要素 | - SRSF protein kinase 1
- mRNA export factor
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キーワード | SPLICING / Complex / Phosphorylation / Inhibition |
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機能・相同性 | 機能・相同性情報
symbiont-mediated activation of host NF-kappaB cascade / symbiont-mediated suppression of host mRNA processing / sperm DNA condensation / regulation of mRNA processing / regulation of mRNA splicing, via spliceosome / Maturation of nucleoprotein / negative regulation of viral genome replication / spliceosomal complex assembly / symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint / positive regulation of viral genome replication ...symbiont-mediated activation of host NF-kappaB cascade / symbiont-mediated suppression of host mRNA processing / sperm DNA condensation / regulation of mRNA processing / regulation of mRNA splicing, via spliceosome / Maturation of nucleoprotein / negative regulation of viral genome replication / spliceosomal complex assembly / symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint / positive regulation of viral genome replication / Replacement of protamines by nucleosomes in the male pronucleus / RNA splicing / chromosome segregation / nuclear matrix / eukaryotic translation initiation factor 2alpha kinase activity / host cell cytoplasm / 3-phosphoinositide-dependent protein kinase activity / DNA-dependent protein kinase activity / ribosomal protein S6 kinase activity / histone H3S10 kinase activity / histone H2AXS139 kinase activity / histone H3S28 kinase activity / histone H4S1 kinase activity / histone H2BS14 kinase activity / histone H3T3 kinase activity / histone H2AS121 kinase activity / Rho-dependent protein serine/threonine kinase activity / histone H2BS36 kinase activity / histone H3S57 kinase activity / histone H2AT120 kinase activity / AMP-activated protein kinase activity / histone H2AS1 kinase activity / histone H3T6 kinase activity / histone H3T11 kinase activity / histone H3T45 kinase activity / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / nuclear speck / protein phosphorylation / symbiont-mediated suppression of host gene expression / innate immune response / protein serine kinase activity / protein serine/threonine kinase activity / regulation of DNA-templated transcription / chromatin / host cell nucleus / magnesium ion binding / endoplasmic reticulum / RNA binding / zinc ion binding / nucleoplasm / ATP binding / metal ion binding / nucleus / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Herpes viral adaptor, REF-binding domain / Herpes viral adaptor-to-host cellular mRNA binding domain / Herpesvirus ICP27-like / Herpesvirus transcriptional regulator family / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site ...Herpes viral adaptor, REF-binding domain / Herpes viral adaptor-to-host cellular mRNA binding domain / Herpesvirus ICP27-like / Herpesvirus transcriptional regulator family / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 PHOSPHATE ION / mRNA export factor / mRNA export factor / SRSF protein kinase 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
Herpes simplex virus (ヘルペスウイルス) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.801 Å |
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データ登録者 | Tunnicliffe, R.B. / Levy, C. / Mould, A.P. / Mckenzie, E.A. / Sandri-Goldin, R.M. / Golovanov, A.P. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | AI107803 | 米国 |
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引用 | ジャーナル: Mbio / 年: 2019 タイトル: Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27. 著者: Tunnicliffe, R.B. / Hu, W.K. / Wu, M.Y. / Levy, C. / Mould, A.P. / McKenzie, E.A. / Sandri-Goldin, R.M. / Golovanov, A.P. |
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履歴 | 登録 | 2017年12月15日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年9月25日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年4月8日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2022年3月30日 | Group: Author supporting evidence / Database references / カテゴリ: database_2 / pdbx_audit_support Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_audit_support.funding_organization |
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改定 1.3 | 2024年1月17日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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