- PDB-6eww: Structure of 14-3-3 zeta in complex with CaMKK2 14-3-3 binding motif -
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Basic information
Entry
Database: PDB / ID: 6eww
Title
Structure of 14-3-3 zeta in complex with CaMKK2 14-3-3 binding motif
Components
14-3-3 protein zeta/delta
ARG-LYS-LEU-SEP-LEU-GLN-GLU-ARG
Keywords
SIGNALING PROTEIN / 14-3-3 protein / calcium/calmodulin-dependent protein kinase kinase 2 / CaMKK2 / phosphorylation
Function / homology
Function and homology information
Golgi reassembly / synaptic target recognition / positive regulation of autophagy of mitochondrion / Ca2+/calmodulin-dependent protein kinase / respiratory system process / NOTCH4 Activation and Transmission of Signal to the Nucleus / regulation of synapse maturation / CAMKK-AMPK signaling cascade / establishment of Golgi localization / tube formation ...Golgi reassembly / synaptic target recognition / positive regulation of autophagy of mitochondrion / Ca2+/calmodulin-dependent protein kinase / respiratory system process / NOTCH4 Activation and Transmission of Signal to the Nucleus / regulation of synapse maturation / CAMKK-AMPK signaling cascade / establishment of Golgi localization / tube formation / Rap1 signalling / negative regulation of protein localization to nucleus / regulation of protein kinase activity / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / calmodulin-dependent protein kinase activity / CaMK IV-mediated phosphorylation of CREB / KSRP (KHSRP) binds and destabilizes mRNA / Activation of RAC1 downstream of NMDARs / GP1b-IX-V activation signalling / Regulation of localization of FOXO transcription factors / Interleukin-3, Interleukin-5 and GM-CSF signaling / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / protein targeting / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / cellular response to glucose starvation / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / Activation of AMPK downstream of NMDARs / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / RHO GTPases activate PKNs / negative regulation of TORC1 signaling / protein sequestering activity / ERK1 and ERK2 cascade / negative regulation of innate immune response / hippocampal mossy fiber to CA3 synapse / regulation of ERK1 and ERK2 cascade / Deactivation of the beta-catenin transactivating complex / Translocation of SLC2A4 (GLUT4) to the plasma membrane / calcium-mediated signaling / TP53 Regulates Metabolic Genes / Negative regulation of NOTCH4 signaling / lung development / regulation of protein stability / cellular response to reactive oxygen species / MAPK cascade / melanosome / protein tyrosine kinase activity / angiogenesis / DNA-binding transcription factor binding / vesicle / transmembrane transporter binding / protein autophosphorylation / blood microparticle / calmodulin binding / cadherin binding / neuron projection / positive regulation of protein phosphorylation / protein domain specific binding / protein phosphorylation / focal adhesion / protein serine kinase activity / protein serine/threonine kinase activity / glutamatergic synapse / ubiquitin protein ligase binding / calcium ion binding / negative regulation of apoptotic process / protein kinase binding / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / signal transduction / RNA binding / extracellular space / extracellular exosome / nucleoplasm / ATP binding / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function
14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein ...14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homology
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