登録情報 | データベース: PDB / ID: 6e1a |
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タイトル | Menin bound to M-89 |
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要素 | Menin |
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キーワード | PROTEIN BINDING / inhibitor / transcription |
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機能・相同性 | 機能・相同性情報
Y-form DNA binding / : / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of JNK cascade / T-helper 2 cell differentiation / MLL1/2 complex / osteoblast development / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes / positive regulation of transforming growth factor beta receptor signaling pathway ...Y-form DNA binding / : / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of JNK cascade / T-helper 2 cell differentiation / MLL1/2 complex / osteoblast development / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes / positive regulation of transforming growth factor beta receptor signaling pathway / cleavage furrow / R-SMAD binding / MLL1 complex / negative regulation of cell cycle / negative regulation of osteoblast differentiation / RHO GTPases activate IQGAPs / response to UV / four-way junction DNA binding / transcription repressor complex / transcription initiation-coupled chromatin remodeling / negative regulation of protein phosphorylation / response to gamma radiation / Post-translational protein phosphorylation / Deactivation of the beta-catenin transactivating complex / phosphoprotein binding / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / Formation of the beta-catenin:TCF transactivating complex / negative regulation of DNA-binding transcription factor activity / nuclear matrix / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / MAPK cascade / protein-macromolecule adaptor activity / double-stranded DNA binding / chromosome, telomeric region / transcription cis-regulatory region binding / negative regulation of cell population proliferation / endoplasmic reticulum lumen / DNA repair / negative regulation of DNA-templated transcription / DNA damage response / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / nucleus / cytosol / cytoplasm類似検索 - 分子機能 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.1 Å |
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データ登録者 | Stuckey, J.A. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | 1-R01-CA-208267-01-A1 | 米国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2019 タイトル: Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. 著者: Aguilar, A. / Zheng, K. / Xu, T. / Xu, S. / Huang, L. / Fernandez-Salas, E. / Liu, L. / Bernard, D. / Harvey, K.P. / Foster, C. / McEachern, D. / Stuckey, J. / Chinnaswamy, K. / Delproposto, ...著者: Aguilar, A. / Zheng, K. / Xu, T. / Xu, S. / Huang, L. / Fernandez-Salas, E. / Liu, L. / Bernard, D. / Harvey, K.P. / Foster, C. / McEachern, D. / Stuckey, J. / Chinnaswamy, K. / Delproposto, J. / Kampf, J.W. / Wang, S. |
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履歴 | 登録 | 2018年7月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年7月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年7月24日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.2 | 2019年12月18日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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