Entry | Database: PDB / ID: 6dwg |
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Title | Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant Q139A |
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Components | Dihydroorotate dehydrogenase (fumarate) |
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Keywords | OXIDOREDUCTASE / dihydroorotate dehydrogenase / Leishmania major / mutant Q139A |
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Function / homology | Function and homology information
dihydroorotate dehydrogenase (fumarate) / dihydroorotate dehydrogenase (fumarate) activity / fumarate metabolic process / dihydroorotate dehydrogenase activity / ciliary plasm / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / nucleotide binding / nucleoplasm / cytoplasmSimilarity search - Function Dihydroorotate Dehydrogenase A; chain A, domain 2 / Dihydroorotate Dehydrogenase A, chain A, domain 2 / Dihydroorotate dehydrogenase, class 1A / Dihydroorotate dehydrogenase, class 1/ 2 / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / Roll / TIM Barrel ...Dihydroorotate Dehydrogenase A; chain A, domain 2 / Dihydroorotate Dehydrogenase A, chain A, domain 2 / Dihydroorotate dehydrogenase, class 1A / Dihydroorotate dehydrogenase, class 1/ 2 / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / Roll / TIM Barrel / Alpha-Beta Barrel / Mainly Beta / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Leishmania major (eukaryote) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 1.9 Å |
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Authors | Reis, R.A.G. / Pinheiro, M.P. / Nonato, M.C. |
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Funding support | Brazil, 2items Organization | Grant number | Country |
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Sao Paulo Research Foundation (FAPESP) | 11/23504-9 | Brazil | Sao Paulo Research Foundation (FAPESP) | 07/08703-0 | Brazil |
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Citation | Journal: To Be Published Title: Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant Q139A Authors: Reis, R.A.G. / Pinheiro, M.P. / Nonato, M.C. |
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History | Deposition | Jun 26, 2018 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jun 26, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jan 1, 2020 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.2 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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