Entry Database : PDB / ID : 6du2 Structure visualization Downloads & linksTitle Structure of Scp1 D96N bound to REST-pS861/4 peptide ComponentsREST-pS861/4 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X2 DetailsKeywords HYDROLASE/PEPTIDE / Phosphatase / Transcription Factor / Phosphorylation / Neurogenesis / HYDROLASE / HYDROLASE-PEPTIDE complexFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of dense core granule biogenesis / negative regulation of amniotic stem cell differentiation / protein serine/threonine phosphatase activity => GO:0004722 / protein serine/threonine phosphatase activity => GO:0004722 / negative regulation of aldosterone biosynthetic process / negative regulation of cortisol biosynthetic process / RNA polymerase II CTD heptapeptide repeat phosphatase activity / negative regulation of transcription regulatory region DNA binding / modification of synaptic structure / Regulation of NPAS4 gene transcription ... negative regulation of dense core granule biogenesis / negative regulation of amniotic stem cell differentiation / protein serine/threonine phosphatase activity => GO:0004722 / protein serine/threonine phosphatase activity => GO:0004722 / negative regulation of aldosterone biosynthetic process / negative regulation of cortisol biosynthetic process / RNA polymerase II CTD heptapeptide repeat phosphatase activity / negative regulation of transcription regulatory region DNA binding / modification of synaptic structure / Regulation of NPAS4 gene transcription / cellular response to electrical stimulus / negative regulation of mesenchymal stem cell differentiation / detection of mechanical stimulus involved in sensory perception of sound / negative regulation by host of viral transcription / cardiac muscle cell myoblast differentiation / negative regulation of calcium ion-dependent exocytosis / neuronal stem cell population maintenance / NGF-stimulated transcription / nervous system process / positive regulation of programmed cell death / auditory receptor cell stereocilium organization / cellular response to glucocorticoid stimulus / regulation of osteoblast differentiation / regulation of alternative mRNA splicing, via spliceosome / positive regulation of stem cell population maintenance / protein-serine/threonine phosphatase / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / somatic stem cell population maintenance / neuromuscular process controlling balance / negative regulation of neuron differentiation / RNA polymerase II core promoter sequence-specific DNA binding / negative regulation of insulin secretion / hematopoietic progenitor cell differentiation / negative regulation of miRNA transcription / Regulation of PTEN gene transcription / transcription repressor complex / positive regulation of neuron differentiation / HDACs deacetylate histones / response to ischemia / DNA-binding transcription repressor activity, RNA polymerase II-specific / negative regulation of neurogenesis / cellular response to xenobiotic stimulus / Potential therapeutics for SARS / RNA polymerase II-specific DNA-binding transcription factor binding / transcription cis-regulatory region binding / chromatin remodeling / response to hypoxia / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / positive regulation of apoptotic process / negative regulation of cell population proliferation / negative regulation of gene expression / negative regulation of DNA-templated transcription / chromatin binding / positive regulation of gene expression / positive regulation of DNA-templated transcription / regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / nucleus / metal ion binding / cytoplasm / cytosol Similarity search - Function : / Dullard phosphatase domain, eukaryotic / CTD small RNA polymerase II polypeptide A phosphatase-like / FCP1 homology domain / NLI interacting factor-like phosphatase / FCP1 homology domain profile. / catalytic domain of ctd-like phosphatases / Zinc finger, C2H2 type / HAD superfamily/HAD-like / zinc finger ... : / Dullard phosphatase domain, eukaryotic / CTD small RNA polymerase II polypeptide A phosphatase-like / FCP1 homology domain / NLI interacting factor-like phosphatase / FCP1 homology domain profile. / catalytic domain of ctd-like phosphatases / Zinc finger, C2H2 type / HAD superfamily/HAD-like / zinc finger / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / HAD superfamily / HAD-like superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Erinaceus europaeus (western European hedgehog)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.5 Å DetailsAuthors Burkholder, N.T. / Mayfield, J.E. / Yu, X. / Irani, S. / Arce, D.K. / Jiang, F. / Matthews, W. / Xue, Y. / Zhang, Y.J. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) 1R01GM104896-01A1 United States Robert A. Welch Foundation F-1778 United States
CitationJournal : J. Biol. Chem. / Year : 2018Title : Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST).Authors : Burkholder, N.T. / Mayfield, J.E. / Yu, X. / Irani, S. / Arce, D.K. / Jiang, F. / Matthews, W.L. / Xue, Y. / Zhang, Y.J. History Deposition Jun 19, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Sep 26, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Nov 7, 2018 Group : Data collection / Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID / _citation_author.name Revision 1.2 Jan 1, 2020 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization
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