Entry Database : PDB / ID : 6d8z Structure visualization Downloads & linksTitle Crystal Structure of the C-terminal Guanine Nucleotide Exchange Factor Module of Human Trio ComponentsTriple functional domain protein Details Keywords SIGNALING PROTEIN / RhoGEF / Dbl Family member / Dbl Homology / Pleckstrin HomologyFunction / homology Function and homology informationFunction Domain/homology Component
cell surface receptor protein tyrosine phosphatase signaling pathway / DCC mediated attractive signaling / regulation of small GTPase mediated signal transduction / extrinsic component of membrane / postsynaptic modulation of chemical synaptic transmission / negative regulation of fat cell differentiation / NRAGE signals death through JNK / RHOJ GTPase cycle / presynaptic active zone / CDC42 GTPase cycle ... cell surface receptor protein tyrosine phosphatase signaling pathway / DCC mediated attractive signaling / regulation of small GTPase mediated signal transduction / extrinsic component of membrane / postsynaptic modulation of chemical synaptic transmission / negative regulation of fat cell differentiation / NRAGE signals death through JNK / RHOJ GTPase cycle / presynaptic active zone / CDC42 GTPase cycle / RHOG GTPase cycle / RHOA GTPase cycle / RAC2 GTPase cycle / RAC3 GTPase cycle / RAC1 GTPase cycle / neuron projection morphogenesis / guanyl-nucleotide exchange factor activity / axon guidance / cell projection / G alpha (12/13) signalling events / G alpha (q) signalling events / postsynapse / non-specific serine/threonine protein kinase / protein serine kinase activity / protein serine/threonine kinase activity / glutamatergic synapse / ATP binding / cytosol / cytoplasm Similarity search - Function Rho GDP/GTP exchange factor Kalirin/TRIO / : / : / SH3-RhoGEF linking unstructured region / : / Divergent CRAL/TRIO domain / CRAL-TRIO lipid binding domain profile. / Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) / CRAL-TRIO lipid binding domain / CRAL-TRIO lipid binding domain superfamily ... Rho GDP/GTP exchange factor Kalirin/TRIO / : / : / SH3-RhoGEF linking unstructured region / : / Divergent CRAL/TRIO domain / CRAL-TRIO lipid binding domain profile. / Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) / CRAL-TRIO lipid binding domain / CRAL-TRIO lipid binding domain superfamily / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Spectrin repeats / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / Immunoglobulin I-set / Immunoglobulin I-set domain / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Immunoglobulin subtype / Immunoglobulin / PH-like domain superfamily / Ig-like domain profile. / Immunoglobulin-like domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Immunoglobulin-like domain superfamily / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.65 Å DetailsAuthors Bandekar, S. / Tesmer, J.J. Funding support United States, 3items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) R01 HL122416-02z United States National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) R01 HL071818 United States National Institutes of Health/National Cancer Institute (NIH/NCI) R01 CA221289 United States
CitationJournal : Sci Signal / Year : 2019Title : Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential.Authors : Bandekar, S.J. / Arang, N. / Tully, E.S. / Tang, B.A. / Barton, B.L. / Li, S. / Gutkind, J.S. / Tesmer, J.J.G. History Deposition Apr 27, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 20, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Feb 27, 2019 Group : Data collection / Database references / Category : citation / Item : _citation.pdbx_database_id_DOI / _citation.titleRevision 1.2 Mar 6, 2019 Group : Data collection / Database referencesCategory : citation / citation_author ... citation / citation_author / database_PDB_rev / database_PDB_rev_record / pdbx_database_proc Item : _citation.journal_abbrev / _citation.journal_volume ... _citation.journal_abbrev / _citation.journal_volume / _citation.pdbx_database_id_PubMed / _citation.title Revision 1.3 Dec 4, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 May 25, 2022 Group : Database references / Structure summary / Category : database_2 / structItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct.titleRevision 1.5 Oct 4, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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