Entry Database : PDB / ID : 6cml Structure visualization Downloads & linksTitle Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 2093) ComponentsMethionyl-tRNA synthetase Details Keywords ligase/ligase inhibitor / synthetase / ligase / methionine / inhibitor / Ligase-Ligase Inhibitor complexFunction / homology Function and homology informationFunction Domain/homology Component
methionine-tRNA ligase / methionine-tRNA ligase activity / methionyl-tRNA aminoacylation / ciliary plasm / ATP binding / cytoplasm Similarity search - Function Methionyl-trna Synthetase; domain 2 / Methionyl-trna Synthetase; domain 2 - #10 / Methionine-tRNA synthetase, type 2 / Anticodon binding domain of methionyl tRNA ligase / Methionyl-tRNA synthetase / Methioninyl-tRNA synthetase core domain / Methionyl-tRNA synthetase, anticodon-binding domain / Isoleucyl-tRNA Synthetase; Domain 1 / Isoleucyl-tRNA Synthetase; Domain 1 / Methionyl/Leucyl tRNA synthetase ... Methionyl-trna Synthetase; domain 2 / Methionyl-trna Synthetase; domain 2 - #10 / Methionine-tRNA synthetase, type 2 / Anticodon binding domain of methionyl tRNA ligase / Methionyl-tRNA synthetase / Methioninyl-tRNA synthetase core domain / Methionyl-tRNA synthetase, anticodon-binding domain / Isoleucyl-tRNA Synthetase; Domain 1 / Isoleucyl-tRNA Synthetase; Domain 1 / Methionyl/Leucyl tRNA synthetase / tRNA synthetases class I (M) / Aminoacyl-tRNA synthetase, class Ia, anticodon-binding / HUPs / Rossmann-like alpha/beta/alpha sandwich fold / Beta Complex / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Beta / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Trypanosoma brucei brucei (eukaryote)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.7 Å DetailsAuthors Barros-Alvarez, X. / Hol, W.G.J. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) R01AI084004 United States
CitationJournal : Rsc Med Chem / Year : 2020Title : Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma bruceiAuthors: Zhang, Z. / Barros-Alvarez, X. / Gillespie, J.R. / Ranade, R.M. / Huang, W. / Shibata, S. / Molasky, N.M.R. / Faghih, O. / Mushtaq, A. / Choy, R.K.M. / de Hostos, E. / Hol, W.G.J. / ... Authors : Zhang, Z. / Barros-Alvarez, X. / Gillespie, J.R. / Ranade, R.M. / Huang, W. / Shibata, S. / Molasky, N.M.R. / Faghih, O. / Mushtaq, A. / Choy, R.K.M. / de Hostos, E. / Hol, W.G.J. / Verlinde, C.L.M.J. / Buckner, F.S. / Fan, E. History Deposition Mar 5, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 13, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Dec 18, 2019 Group : Author supporting evidence / Database references / Category : pdbx_audit_support / struct_ref_seq_difItem : _pdbx_audit_support.funding_organization / _struct_ref_seq_dif.detailsRevision 1.2 Sep 23, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation.year Revision 1.3 Mar 13, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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